Results 1 to 10 of about 50,380 (119)
Co-stimulatory signal deficiency impairs cytotoxic T lymphocyte function in tumor immune evasion: molecular mechanisms and therapeutic implications [PDF]
Journal of Translational MedicineThe generation and maintenance of effective tumor-specific CTL responses require more than antigen recognition. In most settings, TCR engagement must be accompanied by co-stimulatory input, with the B7-1/B7-2–CD28 axis being one of the best-characterized
Junjie Ma +6 more
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Cytomegalovirus infection in HIV-infected and uninfected individuals is characterized by circulating regulatory T cells of unconstrained antigenic specificity. [PDF]
PLoS ONE, 2017 Cytomegalovirus (CMV) infection is associated with immune-suppression in immune-compromised hosts and old adults. We previously showed that ex vivo CMV restimulation of peripheral blood mononuclear cells (PBMC) of CMV-seropositive volunteers expanded CD4+
Adriana Tovar-Salazar, Adriana Weinberg
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Common gamma chain cytokines promote rapid in vitro expansion of allo-specific human CD8+ suppressor T cells. [PDF]
PLoS ONE, 2011 Human CD8(+) regulatory T cells, particularly the CD8(+)CD28(-) T suppressor cells, have emerged as an important modulator of alloimmunity. Understanding the conditions under which these cells are induced and/or expanded would greatly facilitate their ...
Yuming Yu +8 more
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Frontiers in Immunology, 2021 CD28 is well known as a critical T-cell costimulatory receptor involved in T cell activation by binding to its ligands. In this study, CD28 was cloned, and its expression profiles were characterized in flounder (Paralichthys olivaceus); variations of ...
Jing Xing +8 more
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International Journal of Mycobacteriology, 2020 Background: Mycobacterium tuberculosis is able to survive and persist as an intracellular pathogen by modulating its own metabolism and host immunity. The molecules and mechanisms utilized to accomplish this modulation are not fully understood.
Bhawna Sharma, Bhavyata Dua, Beenu Joshi
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miR‐21 sustains CD28 signalling and low‐affinity T‐cell responses at the expense of self‐tolerance
Clinical & Translational Immunology, 2021 Objective miR‐21 is highly expressed in iNKT and activated T cells, but its T‐cell autonomous functions are poorly defined. We sought to investigate the role of miR‐21 in the development and functions of T and iNKT cells, representing adaptive and innate‐
Maya Fedeli +8 more
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Frontiers in Immunology, 2022 Endothelial cells (ECs) can present antigens to circulating effector memory T cells (TEM) and to regulatory T cells (T regs), triggering antigen-specific extravasation at specific sites where foreign antigens are introduced, e.g.
Thomas D. Manes +2 more
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Mediterranean Journal of Hematology and Infectious Diseases, 2023 Multiple myeloma (MM) is a heterogeneous malignancy characterized by the proliferation of abnormal plasma cells in the bone marrow. Multiparametric flow cytometry (MFC) plays a role in the work-up of the disease in view of the aberrant expression of ...
Francesca Fazio +10 more
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Клиническая онкогематология, 2022 Background. The population of non-tumor plasma cells in healthy subjects’ bone marrow is known to be fairly heterogeneous. Among them, there may be a small number of CD19–, CD56+, CD45– plasma cells which differ from the main bulk of the normal ...
E. E. Tolstykh +8 more
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Cell Reports, 2018 Summary: Th17 cells drive autoimmune disease but also control commensal microbes. A common link among antigens from self-proteins or commensal microbiota is relatively low activation of T cell receptor (TCR) and costimulation signaling.
Shankar Revu +7 more
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