Results 21 to 30 of about 48,976 (264)

Restoration of CD28 Expression in CD28− CD8 + Memory Effector T Cells Reconstitutes Antigen-induced IL-2 Production [PDF]

The Journal of Experimental Medicine, 2003
The control of many persistent viral infections by Ag-specific cytolytic CD8+ T cells requires a concurrent virus-specific CD4+ Th cell response. This reflects in part a requirement of activated effector CD8+ T cells for paracrine IL-2 production as a growth and survival factor.
Topp, Max S., Riddell, Stanley R., Akatsuka, Yoshiki, Jensen, Michael C., Blattman, Joseph N., Greenberg, Philip D.   +5 more
openaire   +2 more sources

Antigen-specific recognition is critical for the function of regulatory CD8+CD28− T cells [PDF]

Transplant Immunology, 2010
The immunomodulatory properties of CD8 T cells with regulatory phenotype have become evident. It remains unclear whether the immunomodulatory function of CD8(+)CD28(-) T cells requires antigen-specific TCR interaction with major histocompatibility complex class I (MHC I). We have isolated naïve CD8(+)CD28(-) T suppressor cells (Tsup) from H2-Kk Des-TCR
P, Renner, F C, Popp, E, Eggenhofer, P, Slowik, P, Piso, E K, Geissler, H J, Schlitt, M H, Dahlke   +7 more
openaire   +4 more sources

IL-23 and IL-1β Drive Human Th17 Cell Differentiation and Metabolic Reprogramming in Absence of CD28 Costimulation

Cell Reports, 2018
Summary: Th17 cells drive autoimmune disease but also control commensal microbes. A common link among antigens from self-proteins or commensal microbiota is relatively low activation of T cell receptor (TCR) and costimulation signaling.
Shankar Revu, Jing Wu, Matthew Henkel, Natalie Rittenhouse, Ashley Menk, Greg M. Delgoffe, Amanda C. Poholek, Mandy J. McGeachy   +7 more
doaj   +1 more source

A flexible liposomal polymer complex as a platform of specific and regulable immune regulation for individual cancer immunotherapy

Journal of Experimental & Clinical Cancer Research, 2023
Background The applicability and therapeutic efficacy of specific personalized immunotherapy for cancer patients is limited by the genetic diversity of the host or the tumor.
Chia-Hung Chen, Tzu-Han Weng, Hsiao-Hsuan Huang, Ling-Ya Huang, Kai-Yao Huang, Pin-Rong Chen, Kuang-Yu Yeh, Chi-Ting Huang, Yu-Tzu Chien, Po-Ya Chuang, Yu-Ling Lin, Nu-Man Tsai, Shih-Jen Liu, Yu-Cheng Su, Shun-Long Weng, Kuang-Wen Liao   +15 more
doaj   +1 more source

Arming Cytokine-induced Killer Cells With Chimeric Antigen Receptors: CD28 Outperforms Combined CD28–OX40 “Super-stimulation” [PDF]

Molecular Therapy, 2013
Cytokine-induced killer (CIK) cells raised interest for use in cellular antitumor therapy due to their capability to recognize and destroy autologous tumor cells in a HLA-independent fashion. The antitumor attack of CIK cells, predominantly consisting of terminally differentiated CD8(+)CD56(+) cells, can be improved by redirecting by a chimeric antigen
Hombach, Andreas A, Rappl, Gunter, Abken, Hinrich   +2 more
openaire   +2 more sources

Longitudinal microarray analysis of cell surface antigens on peripheral blood mononuclear cells from HIV+ individuals on highly active antiretroviral therapy

Retrovirology, 2008
Background The efficacy of highly active antiretroviral therapy (HAART) determined by simultaneous monitoring over 100 cell-surface antigens overtime has not been attempted.
Wang Bin, Belov Larissa, Chrisp Jeremy, Dyer Wayne B, Wu Jing, Saksena Nitin K   +5 more
doaj   +1 more source

CAR T cell therapy

Immunological Medicine, 2021
Chimeric antigen receptor (CAR) is generated by fusing a cancer-specific antibody’s antigen recognition site with costimulatory molecules such as CD28 and CD3ζ. T cells transduced with CAR recognizes cancer-specific antigens and kill cancer cells.
Naoki Hosen
doaj   +1 more source

CD28 between tolerance and autoimmunity: the side effects of animal models [version 1; referees: 2 approved]

F1000Research, 2018
Regulation of immune responses is critical for ensuring pathogen clearance and for preventing reaction against self-antigens. Failure or breakdown of immunological tolerance results in autoimmunity.
Nicla Porciello, Martina Kunkl, Loretta Tuosto   +2 more
doaj   +1 more source

Phenolic-glycolipid-1 and lipoarabinomannan preferentially modulate TCR- and CD28-triggered proximal biochemical events, leading to T-cell unresponsiveness in mycobacterial diseases

Lipids in Health and Disease, 2012
Background Advanced stages of leprosy show T cell unresponsiveness and lipids of mycobacterial origin are speculated to modulate immune responses in these patients.
Dagur Pradeep, Sharma Bhawna, Upadhyay Rajni, Dua Bhavyata, Rizvi Arshad, Khan Naim, Katoch Vishwa, Sengupta Utpal, Joshi Beenu   +8 more
doaj   +1 more source

Antigen recognition by autoreactive CD4⁺ thymocytes drives homeostasis of the thymic medulla. [PDF]

PLoS ONE, 2012
The thymic medulla is dedicated for purging the T-cell receptor (TCR) repertoire of self-reactive specificities. Medullary thymic epithelial cells (mTECs) play a pivotal role in this process because they express numerous peripheral tissue-restricted self-
Magali Irla, Lucia Guerri, Jeanne Guenot, Arnauld Sergé, Olivier Lantz, Adrian Liston, Beat A Imhof, Ed Palmer, Walter Reith   +8 more
doaj   +1 more source