Results 11 to 20 of about 228,118 (255)

41BB-based and CD28-based CD123-redirected T-cells ablate human normal hematopoiesis in vivo

Journal for ImmunoTherapy of Cancer, 2020
Background Acute myeloid leukemia (AML) is a hematopoietic malignancy which is biologically, phenotypically and genetically very heterogeneous. Outcome of patients with AML remains dismal, highlighting the need for improved, less toxic therapies ...
Pablo Menendez, Maria Castella, Pedro Marín, Alex Bataller, Jordi Esteve, Diego Sánchez Martínez, Francisco Gutiérrez Agüera, Heleia Roca Ho, Clara Bueno, Matteo Libero Baroni, Talia Velasco Hernandez, Rafael Diaz de la Guardia, Julio Castaño, Eduardo Anguita, Susana Vives, Josep Nomdedeu, Helene Lapillone, Anne E Bras, Vincent H J van der Velden, Jordi Junca, Binje Vick, Irmela Jeremias, Angel Lopez, Marc Sorigue   +23 more
doaj   +2 more sources

CD28- cells are increased in early rheumatoid arthritis and are linked with cytomegalovirus status [PDF]

, 2020
Objective: CD3+CD8+CD28- cells are higher in Rheumatoid Arthritis (RA). The aim of this study was to assess CD3+CD8+CD28- cells in patients with early RA and assess the effects of cytomegalovirus (CMV) seropositivity.
Charlie Thompson (6815657), Ruth Davies (7199222), Ernest H S Choy (16039811), Gareth Jones (34552), Anwen Williams (50387)   +4 more
core   +2 more sources

An investigation into the role of autoimmunity in vitiligo [PDF]

, 2002
Vitiligo is an acquired depigmenting disorder characterised by the loss of functional melanocytes from the cutaneous epidermis. A role for autoimmunity is supported by the presence of circulating antibodies and T lymphocytes which react against ...
Waterman, Elizabeth Ann
core   +6 more sources

CD160Ig fusion protein targets a novel costimulatory pathway and prolongs allograft survival. [PDF]

, 2013
CD160 is a cell surface molecule expressed by most NK cells and approximately 50% of CD8(+) cytotoxic T lymphocytes. Engagement of CD160 by MHC class-I directly triggers a costimulatory signal to TCR-induced proliferation, cytokine production and ...
Freeman, Gordon, T. Ueno, P. Fiorina, Baogong Zhu (399443), B. Zhu, Sayegh, Mohamed, Mohammed Javeed I. Ansari (399445), Antje Habicht (367049), A. Habicht, D'Addio, Francesca, Baogong Zhu, G. J. Freeman, Francesca D’Addio (289857), Mohammed Javeed I Ansari, Takuya Ueno (38813), Andrea Vergani (289866), Zhu, Baogong, F. D'Addio, Antje Habicht, M. H. Sayegh, Takuya Ueno, M. Clarkson, Clarkson, Michael, Habicht, Antje, D’Addio, Francesca, M. J. I. Ansari, Paolo Fiorina, Gordon J Freeman, Andrea Vergani, Mohammed Javeed, I. Ansari, Mohamed H. Sayegh (399444), Ansari, Mohammed Javeed I., Ueno, Takuya, Mohamed H Sayegh, Freeman, Gordon J., Michael Clarkson (399442), Fiorina, Paolo, Gordon J. Freeman (267166), Gordon J. Freeman, Vergani, Andrea, Mohamed H. Sayegh, Paolo Fiorina (251367), Michael Clarkson, A. Vergani, Sayegh, Mohamed H., Francesca D'Addio   +46 more
core   +2 more sources

A flexible liposomal polymer complex as a platform of specific and regulable immune regulation for individual cancer immunotherapy

Journal of Experimental & Clinical Cancer Research, 2023
Background The applicability and therapeutic efficacy of specific personalized immunotherapy for cancer patients is limited by the genetic diversity of the host or the tumor.
Chia-Hung Chen, Tzu-Han Weng, Hsiao-Hsuan Huang, Ling-Ya Huang, Kai-Yao Huang, Pin-Rong Chen, Kuang-Yu Yeh, Chi-Ting Huang, Yu-Tzu Chien, Po-Ya Chuang, Yu-Ling Lin, Nu-Man Tsai, Shih-Jen Liu, Yu-Cheng Su, Shun-Long Weng, Kuang-Wen Liao   +15 more
doaj   +1 more source

Longitudinal microarray analysis of cell surface antigens on peripheral blood mononuclear cells from HIV+ individuals on highly active antiretroviral therapy

Retrovirology, 2008
Background The efficacy of highly active antiretroviral therapy (HAART) determined by simultaneous monitoring over 100 cell-surface antigens overtime has not been attempted.
Wang Bin, Belov Larissa, Chrisp Jeremy, Dyer Wayne B, Wu Jing, Saksena Nitin K   +5 more
doaj   +1 more source

CAR T cell therapy

Immunological Medicine, 2021
Chimeric antigen receptor (CAR) is generated by fusing a cancer-specific antibody’s antigen recognition site with costimulatory molecules such as CD28 and CD3ζ. T cells transduced with CAR recognizes cancer-specific antigens and kill cancer cells.
Naoki Hosen
doaj   +1 more source

CD28 between tolerance and autoimmunity: the side effects of animal models [version 1; referees: 2 approved]

F1000Research, 2018
Regulation of immune responses is critical for ensuring pathogen clearance and for preventing reaction against self-antigens. Failure or breakdown of immunological tolerance results in autoimmunity.
Nicla Porciello, Martina Kunkl, Loretta Tuosto   +2 more
doaj   +1 more source

Combination of cytokine responses indicative of latent TB and active TB in Malawian adults. [PDF]

, 2013
BACKGROUND: An IFN-γ response to M. tuberculosis-specific antigens is an effective biomarker for M. tuberculosis infection but it cannot discriminate between latent TB infection and active TB disease. Combining a number of cytokine/chemokine responses to
Tom H Ottenhoff, T Mark Doherty, Dacombe, R., Ottenhoff, T.H., Crampin, Amelia C, Chaguluka, S., Hazel M Dockrell, Doherty, T.M., Tom H. Ottenhoff (475123), Amelia C Crampin, Hur, Yun-Gyoung, Crampin, Amelia C., Russell Dacombe (369437), Chaguluka Steven, Hur, Y.G., Crampin Amelia C., Anne Ben-Smith (244056), Doherty, T. Mark, Lalor, Maeve K., Lalor, M.K., Doherty T. Mark, Maeve K. Lalor (356874), Dockrell Hazel M., Ottenhoff, Tom H, Lalor, Maeve K, Kumar, Anil, Steven Chaguluka (486585), Dacombe Russell, Ottenhoff, Tom H., Gorak-Stolinska, P., Hur Yun-Gyoung, Crampin, A.C., Doherty, T Mark, T. Mark Doherty (79672), Ben-Smith, A., Ottenhoff Tom H., Lalor Maeve K., Chaguluka, Steven, Maeve K Lalor, Patricia Gorak-Stolinska (356875), Amelia C. Crampin (239427), Gorak-Stolinska, Patricia, Dacombe, Russell, Ben-Smith Anne, Ben-Smith, Anne, Dockrell, Hazel M., Steven Chaguluka, Hazel M. Dockrell (255469), Dockrell, H.M., Anne Ben-Smith, Russell Dacombe, Yun-Gyoung Hur (486584), Yun-Gyoung Hur, Gorak-Stolinska Patricia, Dockrell, Hazel M, Patricia Gorak-Stolinska   +55 more
core   +1 more source

Phenolic-glycolipid-1 and lipoarabinomannan preferentially modulate TCR- and CD28-triggered proximal biochemical events, leading to T-cell unresponsiveness in mycobacterial diseases

Lipids in Health and Disease, 2012
Background Advanced stages of leprosy show T cell unresponsiveness and lipids of mycobacterial origin are speculated to modulate immune responses in these patients.
Dagur Pradeep, Sharma Bhawna, Upadhyay Rajni, Dua Bhavyata, Rizvi Arshad, Khan Naim, Katoch Vishwa, Sengupta Utpal, Joshi Beenu   +8 more
doaj   +1 more source