Results 11 to 20 of about 48,976 (264)
Psoriasis risk allele function in activated Th1/17 cells with "memory" to antigen exposure. [PDF]
PLoS ONEMost causal variants for complex diseases are expected to affect gene regulation in a cell- and context-specific manner. Hence, identification of such dynamically functioning variants requires functional readouts in disease-relevant tissues and context ...
Bayazit Yunusbayev +6 more
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The Expression of CD28 and Its Synergism on the Immune Response of Flounder (Paralichthys olivaceus) to Thymus-Dependent Antigen [PDF]
Frontiers in Immunology, 2021 CD28 is well known as a critical T-cell costimulatory receptor involved in T cell activation by binding to its ligands. In this study, CD28 was cloned, and its expression profiles were characterized in flounder (Paralichthys olivaceus); variations of ...
Jing Xing +8 more
doaj +3 more sources
The CD28-Transmembrane Domain Mediates Chimeric Antigen Receptor Heterodimerization With CD28 [PDF]
Frontiers in Immunology, 2021 Anti-CD19 chimeric antigen receptor (CD19-CAR)-engineered T cells are approved therapeutics for malignancies. The impact of the hinge domain (HD) and the transmembrane domain (TMD) between the extracellular antigen-targeting CARs and the intracellular signaling modalities of CARs has not been systemically studied.
Yannick D. Muller +28 more
openaire +7 more sources
Cytomegalovirus infection in HIV-infected and uninfected individuals is characterized by circulating regulatory T cells of unconstrained antigenic specificity. [PDF]
PLoS ONE, 2017 Cytomegalovirus (CMV) infection is associated with immune-suppression in immune-compromised hosts and old adults. We previously showed that ex vivo CMV restimulation of peripheral blood mononuclear cells (PBMC) of CMV-seropositive volunteers expanded CD4+
Adriana Tovar-Salazar, Adriana Weinberg
doaj +1 more source
Common gamma chain cytokines promote rapid in vitro expansion of allo-specific human CD8+ suppressor T cells. [PDF]
PLoS ONE, 2011 Human CD8(+) regulatory T cells, particularly the CD8(+)CD28(-) T suppressor cells, have emerged as an important modulator of alloimmunity. Understanding the conditions under which these cells are induced and/or expanded would greatly facilitate their ...
Yuming Yu +8 more
doaj +1 more source
International Journal of Mycobacteriology, 2020 Background: Mycobacterium tuberculosis is able to survive and persist as an intracellular pathogen by modulating its own metabolism and host immunity. The molecules and mechanisms utilized to accomplish this modulation are not fully understood.
Bhawna Sharma, Bhavyata Dua, Beenu Joshi
doaj +1 more source
Frontiers in Immunology, 2022 Endothelial cells (ECs) can present antigens to circulating effector memory T cells (TEM) and to regulatory T cells (T regs), triggering antigen-specific extravasation at specific sites where foreign antigens are introduced, e.g.
Thomas D. Manes +2 more
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miR‐21 sustains CD28 signalling and low‐affinity T‐cell responses at the expense of self‐tolerance
Clinical & Translational Immunology, 2021 Objective miR‐21 is highly expressed in iNKT and activated T cells, but its T‐cell autonomous functions are poorly defined. We sought to investigate the role of miR‐21 in the development and functions of T and iNKT cells, representing adaptive and innate‐
Maya Fedeli +8 more
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Mediterranean Journal of Hematology and Infectious Diseases, 2023 Multiple myeloma (MM) is a heterogeneous malignancy characterized by the proliferation of abnormal plasma cells in the bone marrow. Multiparametric flow cytometry (MFC) plays a role in the work-up of the disease in view of the aberrant expression of ...
Francesca Fazio +10 more
doaj +1 more source
Клиническая онкогематология, 2022 Background. The population of non-tumor plasma cells in healthy subjects’ bone marrow is known to be fairly heterogeneous. Among them, there may be a small number of CD19–, CD56+, CD45– plasma cells which differ from the main bulk of the normal ...
E. E. Tolstykh +8 more
doaj +1 more source