Results 181 to 190 of about 142,249 (285)

Serum Proteomic Signatures of RA Risk and Response: Analysis of the APIPPRA Trial

Arthritis &Rheumatology, Accepted Article.
Objective To identify serum protein signatures associated with progression to rheumatoid arthritis (RA) and response to abatacept in at‐risk individuals. Methods A total of 440 serum samples from 118 APIPPRA study participants were selected from baseline to RA onset for 46 RA progressors or to study end for 72 participants who did not develop RA ...
Marianna Jasenecova, Carl Coyle, Alina Mihalovits, Sarah Ryan, Elizabeth Pook, Esperanza Perucha, Gabrielle Harker, Melody Chin, Sam Norton, Andrew P. Cope   +9 more
wiley   +1 more source

Ancestral reconstruction supports that loss of Nef-mediated T cell modulation coincided with the emergence of pathogenic lentiviruses. [PDF]

J Virol
Baldino AM, Mumby MJ, Edgar CR, Olabode AS, Poon AFY, Dikeakos JD.   +5 more
europepmc   +1 more source

Cold atmospheric plasma‐mediated tumor microenvironment remodeling for cancer treatment

BMEMat, EarlyView.
Schematic presentation of CAP‐mediated TME remodeling. This review summarizes recent efforts in cold atmospheric plasma (CAP) application in cancer treatment, highlighting the anticancer potential of CAP, molecular mechanisms, and future perspectives for further improvement and clinical translation.
Israr Khan, Qiujie Fang, Cao Fei, Ziyuan Wang, Zhaowei Chen, Guojun Chen, Zhiming Xu, Shu Xu, Zhitong Chen   +8 more
wiley   +1 more source

Abnormal T-Cell activation and cytotoxic T-Cell frequency discriminate symptom severity in myalgic encephalomyelitis/chronic fatigue syndrome. [PDF]

J Transl Med
Lee JS, Lacerda E, Kingdon C, Abken E, Susannini G, Dockrell HM, Nacul L, Cliff JM.   +7 more
europepmc   +1 more source

Label‐Free Holographic Imaging Flow Cytometry With Deep‐Learning‐Based Detection and Classification of Thousands of Cells Per Second

Cytometry Part A, EarlyView.
ABSTRACT We present a new end‐to‐end neural network approach for real‐time biological cell detection and classification via label‐free quantitative imaging flow cytometry based on digital holography, offering a comprehensive representation of cellular structures without the need for chemical cell staining. In contrast to previous studies, our method is
Dana Yagoda‐Aharoni, Eden Dotan, Matan Dudaie, Natan T. Shaked   +3 more
wiley   +1 more source

Chimeric Antigen Receptor T-Cell Therapy: More Than an Anti-Cancer Drug. [PDF]

HLA
Schenk HCM, Gille I, Arana C, Rovira J, Palou E, Diekmann F, Roelen DL, Heemskerk MHM, Heidt S.   +8 more
europepmc   +1 more source

PD‐1/PD‐L1 in Hepatocellular Carcinoma (2014–2024): A Combined Macro and Micro Analysis of Immunotherapy Implications

iNew Medicine, EarlyView.
ABSTRACT Hepatocellular carcinoma (HCC) represents a significant global health issue, with the PD‐1/PD‐L1 axis serving a pivotal target for immunotherapy in this malignancy. However, a comprehensive bibliometric analysis of PD‐1/PD‐L1 research in HCC is lacking.
Xingyu Zhu, Lin Tang, Hongyan Li, Hao Li, Jiamei Wang   +4 more
wiley   +1 more source

Correction: Non-superagonist CD28-based dual-signal T cell engager targeting KK-LC-1 enhances antitumor efficacy. [PDF]

J Immunother Cancer
europepmc   +1 more source

Dextran-based T-cell expansion nanoparticles for manufacturing CAR T cells with augmented efficacy. [PDF]

Nat Commun
Zheng T, Ramanathan K, Ormhøj M, Hansen MR, Halldórsdóttir HR, Li H, Munk KK, Rodriguez-Pardo C, Friis RUW, Seder I, Heegaard PMH, Qvortrup K, Abken H, Sun Y, Hadrup SR.   +14 more
europepmc   +1 more source

Circ_0006174 Drives Triple Negative Breast Cancer Progression and Immune Escape Through Regulating miR‐3139/PD‐L1 Axis

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Triple‐negative breast cancer (TNBC) is characterized as an aggressive malignancy with limited therapeutic options. The circular RNA circ_0006174 has been implicated in oncogenic processes across various cancers; however, its specific role in the pathogenesis of TNBC remains unclear.
Yong‐Zhe Tang, Li Yang, Ling Wang, Xiao‐Qing Zhang, Jie Wang   +4 more
wiley   +1 more source