Results 231 to 240 of about 73,275 (286)

CD28-mediated linear and parallel costimulatory signaling cooperatively regulate CAR-T cell functions via CAR-CD28 microclusters. [PDF]

Commun Biol
Nishikawa T, Takeuchi A, Machiyama H, Wakamatsu E, Nishijima H, Furuhata M, Toyota H, Nishi W, Matsushima R, Yoshida Y, Harada K, Yokosuka T.   +11 more
europepmc   +1 more source

Integrated scFv identification and CAR T cell generation for AML targeting in vivo

International Journal of Cancer, Volume 158, Issue 4, Page 994-1007, 15 February 2026.
What's new? Acute myeloid leukemia (AML) is a rapidly progressing blood cancer. Advancing chimeric antigen receptor (CAR) T cell therapies, particularly through rapid translation of single chain variable fragment (scFv) discovery into CAR constructs, may improve clinical outcomes, especially the development of patient individualized CAR T cells.
Yi Liu, Annika Lauk, David Sedloev, Josephine Brysting, Ela Cetin, Chunan Liu, Maximilian Mönnig, Thomas Luft, Haiyang Yun, Michael Schmitt, Tim Sauer, Fengbiao Zhou, Christian Rohde, Carsten Müller‐Tidow   +13 more
wiley   +1 more source

Engineering the next generation of CAR T- cells: precision modifications, logic gates and universal strategies to overcome exhaustion and tumor resistance. [PDF]

Front Oncol
Garcia-Robledo JE, Cabrera-Salcedo S, Brandauer AM, Romano F, Rengifo-Martinez J, Toro-Pedroza A, Victoria JS, Rios-Serna LJ, Loukanov A, Cardona AF, Genovese P, Baena JC.   +11 more
europepmc   +1 more source

Synthetic Cell‐Based Tissues for Bottom‐Up Assembly of Artificial Lymphatic Organs

Advanced Healthcare Materials, Volume 15, Issue 5, 2 February 2026.
Synthetic cells have emerged as a novel biomimetic approach for fundamental research and therapeutic interventions. T cell activating synthetic cells are able to form 3D tissue‐like structures by self‐assembly into lymphatic bottom‐up tissues (lymphBUT) with tunable biochemical and biomechanical functionalities as well as metabolic activity are ...
Anna Burgstaller, Tamara Nink, Niklas Walter, Erick Angel Lopez Lopez, Hsin‐Fang Chang, Oskar Staufer   +5 more
wiley   +1 more source

Application of nanobody‑based CAR‑T in tumor immunotherapy (Review). [PDF]

Int J Mol Med
Liu H, Liu X, Zhou X, Duan S, Huang X, Fei H, Kou Y.   +6 more
europepmc   +1 more source

3D Bioprinted Human Synovium‐Cartilage Models Mimic Rheumatoid Arthritis Microenvironment and Recapitulate In Vivo Therapeutic Responses

Advanced Materials, Volume 38, Issue 8, 6 February 2026.
This study presents human in vitro rheumatoid arthritis models using chondrocytes recellularized type II collagen scaffold and 3D‐bioprinted Gelatin‐Matrigel hydrogels with fibroblast‐like synoviocytes, pro‐inflammatory macrophages, and protective barrier macrophages, closely recapitulating key rheumatoid arthritis pathological features.
Huiqun Zhou, Zhen Zhang, Yulei Mu, Liang Ma, Xu Hu, Bangheng Liu, Dong‐An Wang   +6 more
wiley   +1 more source

Exhaustion-Resistant CD8 ⁺ T Cells in Ankylosing Spondylitis: A Proposed Three-Axis Model. [PDF]

Immunology
Zhang X, Jia L, Lin X, Zhou L.
europepmc   +1 more source

T Cell Glycoengineering to Modulate Immune‐Tumor Crosstalk: A Universal Non‐Genetic Strategy for Enhanced Tumor Immunotherapy

Advanced Science, Volume 13, Issue 8, 9 February 2026.
This study describes a T cell surface engineering strategy that integrates polymer materials with tumor immunology, aiming to achieve broad‐spectrum anti‐tumor applications of glycopolymer‐engineered T (G‐T) cells via non‐genetic modification. Glycopolymer engineering generally modulates immune‐tumor crosstalk through specific cell‐cell interactions ...
Lihua Yao, He Yang, Fangjian Shan, Xiaomeng Niu, Yichen Wang, Hengyuan Zhang, Sujian Wang, Gaojian Chen, Hong Chen   +8 more
wiley   +1 more source

Chimeric antigen receptor T cell therapy: Revolutionizing cancer treatment. [PDF]

World J Clin Oncol
Arjumand S, Raj A, Prattay KMR, Omer HBM, Azam F.   +4 more
europepmc   +1 more source

Single‐Cell Dissection Reveals Immune Dysregulation After CD5 or CD7‐Directed Chimeric Antigen Receptor T‐Cell Therapy

Advanced Science, Volume 13, Issue 8, 9 February 2026.
Single‐cell RNA/TCR/BCR sequencing reveals that 5CAR therapy in T‐ALL induces T‐cell exhaustion, reduces EBV‐associated TCRs, lowers TCR/BCR diversity, and increases NK/DC/monocyte activation and function. In contrast, 7CAR therapy reduces multiple pathogen‐associated TCRs, enhances NK cell activation and function, decreases monocyte activation, and ...
Yuechen Luo, Haixiao Zhang, Kaiting Tang, Yiming Wang, Huajiang Dong, Wei Qi, Lingling Shan, Yue Tan, Liping Zhao, Jun Shi, Erlie Jiang, Jing Pan, Xiaoming Feng   +12 more
wiley   +1 more source