Results 241 to 250 of about 73,275 (286)

CAR T Cell Therapy for Rheumatoid Arthritis. [PDF]

Clin Rev Allergy Immunol
Freeley M.
europepmc   +1 more source

FK 506: Pharmacology and molecular action [PDF]

, 1993
Fung, J, Starzl, TE, Thomson, AW, Woo, J
core  

CD27 and ICOS as Targets of PD‐1/PD‐L1 Signaling to Regulate Resident Memory CD8+ T‐Cell‐Mediated Pulmonary Protection and Pathology

Advanced Science, Volume 13, Issue 7, 3 February 2026.
Here it is revealed that the costimulatory receptors CD27 and ICOS are essential for the long‐term maintenance of PD‐1high CD8+ TRM cells following influenza infection. PD‐L1 blockade enhances the proliferation and activation of these cells through Nur77 activation downstream of the CD27/ICOS signaling axis, thereby boosting host immunity against ...
Yuanyuan Chen, Zhenzhen Wang, Liqiang Song, Qianqian Chen, Hang Zhang, Tao Pan, Jianli Pan, Sheng Zhao, Ting Shang, Hong'en Xu, Xing Lv, Jing Li, Fei Kang, Yongzhan Nie, Feng Zhao, Lei Shi, Zheng Wang   +16 more
wiley   +1 more source

EVOLVE platform, a trispecific T cell engager with integrated CD2 costimulation, for the treatment of solid and hematologic tumors. [PDF]

Proc Natl Acad Sci U S A
Sergeeva OA, Jin G, Sarkar M, Zeiger J, Dhindwal S, Chin SS, Abulizi A, Lai Z, Brown C, DeMaria WG, Ryan D, An X, Karp HJ, Teran E, Yuan C, Klaskin D, Reeve TA, Yu GK, Tam EM, Kaech SM, Preyer M, Matis L, Fine JS, Martomo SA, Myers JS.   +24 more
europepmc   +1 more source

Surface‐Associated Proteins on Extracellular Vesicles Remodel the Tumor Microenvironment by Potentiating TGF‐β Signaling in a Contact‐Dependent Manner

Advanced Science, Volume 13, Issue 8, 9 February 2026.
Extracellular vesicles (EVs) released from TGF‐β‐activated CAFs are enriched with ECM proteins such as TSG6 and THBS1, which facilitate their binding to recipient cell membranes. This EV–cell interaction promotes the clustering of CD44 and TGF‐β receptors on the target cell surface, thereby potentiating TGF‐β signaling activity. This study highlights a
Chao Li, Agustin Enciso‐Martinez, Lizhe Zhu, Sarah A. Rotman, Peter A. van Veelen, Roman I. Koning, Hailiang Mei, Peter ten Dijke   +7 more
wiley   +1 more source

Overcoming the undruggable barrier: Structure-guided discovery of a potent small molecule CD28 antagonist with translational potential. [PDF]

Biomed Pharmacother
Upadhyay S, Nada H, Cho S, Gabr MT.
europepmc   +1 more source

Cancer Stem Cells Shift Metabolite Acetyl‐Coenzyme A to Abrogate the Differentiation of CD103+ T Cells

Advanced Science, Volume 13, Issue 8, 9 February 2026.
Lei et al. demonstrate that cancer stem cells (CSCs) play a pivotal role in impairing the differentiation of CD103+ T cells in patients with non‐small‐cell lung cancer. The key mechanism involves CSC‐derived acetyl‐CoA, which disrupts CD103+ T cell differentiation by sequentially inducing acetylation and ubiquitination of the Blimp‐1 protein. Targeting
Jiaxin Lei, Huiyan Ji, Jing Guo, Mengdi Liu, Danhua Su, Yiran Zheng, Lin Xu, Qinghua Cao, Tao Ren, Jun Gui, Zhenke Wen   +10 more
wiley   +1 more source

From innate-like to innate: the next wave of off-the-shelf CAR immunotherapies. [PDF]

Front Immunol
Feng Y, Yang Z, Zhou Y, Liang Y, Zhao H.
europepmc   +1 more source

NUDT21‐mediated Alternative Polyadenylation of CDK19 Reprograms Cholesterol Biosynthesis to Drive Colorectal Cancer Progression

Advanced Science, Volume 13, Issue 7, 3 February 2026.
NUDT21 is overexpressed in colorectal cancer tumors and promotes colorectal cancer progression. NUDT21 promotes the production of a cyclin‐dependent kinase 19 (CDK19) mRNA isoform with a long 3′ UTR, which enhances cytoplasmic export and translation. Truncation of the CDK19 long 3′ UTR phenocopies NUDT21 loss, recapitulating the defects in cholesterol ...
Yeping Yu, Jixin Ma, Minwei Zhou, Xiaodong Gu, Yiming Zhou, Zhenyang Li, Tianyu Zhang, Wei Gong, Chuanxin Huang, Jianbin Xiang   +9 more
wiley   +1 more source

P329G-engager: a universal mix & match antibody-based adaptor platform for cancer immunotherapy. [PDF]

MAbs
Surowka M, Darowski D, Hutter-Karakoc I, Claus C, Ferrara-Koller C, Freimoser-Grundschober A, Hofer T, Sam J, Gianotti R, Sobieniecki A, Assisi D, Challier J, Leclair S, Mössner E, Amann M, Umaña P, Klein C.   +16 more
europepmc   +1 more source