Results 261 to 270 of about 73,275 (286)

A comparison of chimeric antigen receptors containing CD28 versus 4-1BB costimulatory domains

Nature Reviews Clinical Oncology, 2021
Chimeric antigen receptors (CARs) are engineered proteins designed to target T cells to cancer cells. To effectively activate the T cells in which they are expressed, CARs must contain a costimulatory domain. The CAR T cell products approved for the treatment of B cell lymphomas and/or acute lymphoblastic leukaemia or multiple myeloma incorporate ...
Kathryn M. Cappell, James N. Kochenderfer   +1 more
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CD28- T lymphocytes. Antigenic and functional properties.

The Journal of Immunology, 1993
Abstract A subset of CD8+ alpha beta-TCR/CD3+ T lymphocytes in adult human peripheral blood lacks expression of CD28, a membrane receptor for the B7/BB1 B cell differentiation Ag that is involved in T cell activation. CD28-8+ T cells were not observed in the thymus and were present at only low frequency in cord blood, suggesting that ...
M, Azuma, J H, Phillips, L L, Lanier
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B70 antigen is a second ligand for CTLA-4 and CD28

Nature, 1993
The membrane antigen B7/BB1 (refs 1, 2) is expressed on activated B cells, macrophages and dendritic cells, and binds to a counter-receptor, CD28, expressed on T lymphocytes and thymocytes. Interaction between CD28 and B7 results in potent costimulation of T-cell activation initiated through the CD3/T-cell receptor complex.
M, Azuma, D, Ito, H, Yagita, K, Okumura, J H, Phillips, L L, Lanier, C, Somoza   +6 more
openaire   +2 more sources

Antigen‐specific targeting of CD28‐mediated T cell co‐stimulation using chimeric single‐chain antibody variable fragment‐CD28 receptors

European Journal of Immunology, 1996
AbstractT cells require two distinct signals for optimal activation. One is an antigen‐specific signal and is provided by engagement of the T cell receptor (TCR). The second is an antigen‐independent signal mediated by engagement of the T cell surface molecule CD28 with members of the B7 family.
L, Alvarez-Vallina, R E, Hawkins
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The Role of the CD28 Receptor During T Cell Responses to Antigen

Annual Review of Immunology, 1993
The CD28 receptor is stimulated during the contact of T cells with antigen-presenting cells. A counter-receptor for CD28 is the B7 molecule expressed on activated B cells, dendritic cells, and macrophages. B7 also binds to CTLA-4, a receptor that is structurally related to CD28.
P S, Linsley, J A, Ledbetter
openaire   +2 more sources

Advancements on phenotypic and functional characterization of non–antigen-specific CD8+CD28− regulatory T cells

Human Immunology, 2008
Among the different regulatory T lymphocyte (Treg) subpopulations, non-antigen-specific CD8+CD28- Treg (CD8+CD28- Treg) have been characterized for being involved in the pathogenesis of autoimmune diseases and cancer. A better phenotypic and functional characterization of this regulatory T-cell subset could help in identifying modulators of their ...
FENOGLIO, DANIELA, FERRERA, FRANCESCA, FRAVEGA M., BALESTRA P., BATTAGLIA F., PROIETTI M., ANDREI C., OLIVE D., LA CAVA A. ., INDIVERI, FRANCESCO, FILACI, GILBERTO   +10 more
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Functional expression of CD28 on T cell antigen receptor γ/δ‐bearing T lymphocytes

European Journal of Immunology, 1989
AbstractT lymphocytes express a T cell antigen receptor (TcR) complex composed of either an TcR α/β or TcR γ/δ heterodimer in noncovalent association with the CD3 glycoproteins. CD28, a 44‐kDa disulfide‐linked homodimer, is present on the surface of the majority of TcR α/β‐bearing T lymphocytes.
R, Testi, L L, Lanier
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The generation of memory antigen‐specific cytotoxic T cell responses by CD28/CD80 interactions in the absence of antigen

European Journal of Immunology, 1997
AbstractThe interaction of co‐stimulatory molecules CD80/CD86 on antigen‐presenting cells with CD28 on naive CD8+ cytotoxic T (Tc) cells is understood to be critical in the induction of Tc effectors. CD80 is capable of providing signal 2 for the activation of Tc cells, but has no effect if encountered in the absence of specific peptide/MHC complexes ...
K, Flynn, A, Müllbacher
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Regulation of NF-κB Nuclear Activity in Peripheral Blood Mononuclear Cells: Role of CD28 Antigen

Cellular Immunology, 1994
The NF-kappa B/rel family of transcription factors regulates the expression of a number of genes, including interleukin 2 (IL-2), IL-2 receptor alpha chain (Tac), and others, controlling T lymphocyte activation. The CD28 antigen is involved in regulation of T cell activation. To investigate whether CD28 antigen regulates NF-kappa B factors, we analyzed
Romano MF, Bisogni R, Lamberti A, TURCO, Maria Caterina, PETRELLA, Antonello, Tassone P, Van Lier R, Formisano S, Venuta S.   +8 more
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Expression of the T-cell activation antigens CD27 and CD28 in normal and psoriatic skin

Clinical and Experimental Dermatology, 1996
Activated T lymphocytes are thought to be involved in the pathogenesis of psoriasis. From studies with peripheral blood T lymphocytes it is known that T cells show a decrease in membrane expression of CD27 molecules during continuous antigenic stimulation.
de Rie, M. A., Cairo, I., van Lier, R. A., Bos, J. D.   +3 more
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