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CD4+CD45RA+T cells from adults respond to recall antigens after CD28 ligation

International Immunology, 1996
The leukocyte common antigen isoforms CD45RA and CD45RO have long been used to discriminate human naive and memory T cells respectively. This model was largely based on the observation that CD45RO+ T cells respond preferentially to and show a higher frequency of precursors specific for recall antigens.
D, Pilling   +3 more
openaire   +2 more sources

[Construction of 3D model of CD28 chimeric antibody with its antigen docked].

Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology, 2013
To construct a 3D model of the chimeric antibodies (AntiCD28: ch-2F5) with corresponding antigen molecule docked to theoretically verify the rationality of the binding of antibody with its antigen and to provide a method of 3D identification between antigen and antibody and spatial structure analysis.We analyzed the sequence by submitting it to http ...
Gang, Cheng   +5 more
openaire   +1 more source

Molecular cloning and sequencing of a cDNA encoding the feline T-cell antigen CD28 homologue

Immunogenetics, 1999
Immunogenetics (1999) 50:369–370 Q Springer-Verlag 1999The nucleotide sequence data reported in this paper have beensubmitted to the DDBJ nucleotide sequence database and havebeen assigned the accession number AB025316Y. Nishimura 7 T. Miyazawa 7 Y. Ikeda 7 Y. IzumiyaK. Nakamura 7 E. Sato 7 E.
Y, Nishimura   +7 more
openaire   +2 more sources

T cell antigen CD28 binds to the GRB‐2/SOS complex, regulators of p21ras

European Journal of Immunology, 1995
AbstractThe T cell molecule CD28 provides a co‐stimulatory signal that is required for T cell proliferation, and has been implicated in the control of T cell anergy. An important clue to the signaling mechanism of CD28 is the finding that CD28 can bind to phosphatidylinositol 3‐kinase (PI 3‐kinase) by means of a cytoplasmic phospho‐YMNM (pYMNM) motif ...
H, Schneider   +4 more
openaire   +2 more sources

CD8+CD28 T suppressor cells and the induction of antigen‐specific, antigen‐presenting cell‐mediated suppression of Th reactivity

Immunological Reviews, 2001
Summary: Human CD8+CD28− suppressor T cells (Ts) are a subset of T cells generated in the course of in vitro and in vivo immunizations. Ts recognize MHC class I:peptide complexes and inhibit the reactivity of T helper cells (Th) with cognate antigen specificity.
R, Cortesini   +3 more
openaire   +2 more sources

Direct helper T cell‐induced B cell differentiation involves interaction between T cell antigen CD28 and B cell activation antigen B7

European Journal of Immunology, 1991
AbstractCognate interactions between major histocompatibility complex class II antigen (Ag)‐reactive CD4+ T helper (Th) and Ag‐presenting B cells induce first the activation of B cells and their subsequent differentiation into Ig‐secreting cells (IgSC).
N K, Damle, P S, Linsley, J A, Ledbetter
openaire   +2 more sources

CD28 COSTIMULATION IN ALLOIMMUNE RESPONSES AGAINST MAJOR AND MINOR HISTOCOMPATIBILITY ANTIGENS

Transplantation, 1999
Howard K. Song   +6 more
openaire   +1 more source

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