Results 51 to 60 of about 778 (150)

Nanobodies against African swine fever virus p72 and CD2v proteins as reagents for developing two cELISAs to detect viral antibodies

Virologica Sinica
African swine fever virus (ASFV) poses a significant threat to the global swine industry. Currently, there are no effective vaccines or treatments available to combat ASFV infection in pigs. The primary means of controlling the spread of the disease is through rapid detection and subsequent elimination of infected pig.
Jiahong Zhu, Qingyuan Liu, Liuya Li, R. Zhang, Yueting Chang, Jiakai Zhao, Siyu Liu, Xinyu Zhao, Xu Chen, Yani Sun, Qin Zhao   +10 more
openalex   +3 more sources

Development of a subunit vaccine against virus of african svine virus based on cd2v protein with immunoinformatics and molecular dynamics methods

Kristallografiâ
A subunit vaccine against the African swine fever virus (ASF) has been designed using immunoinformatics and molecular dynamics methods. The three-dimensional structure of the selected immunogenic protein of the ASF-CD2v virus was modelled, and its topology relative to the membrane was predicted. B- and T-cell epitopes for the supramembrane part of CD2v
A. S. Ivanovsky, В. И. Тимофеев, А В Калач, Y. V. Kordonskaya, М. А. Марченкова, Yu. V. Pisarevsky, Y. A. Dyakova, M. V. Kovalchuk   +7 more
openalex   +3 more sources

Identification of Promiscuous African Swine Fever Virus T-Cell Determinants Using a Multiple Technical Approach [PDF]

, 2021
The development of subunit vaccines against African swine fever (ASF) is mainly hindered by the lack of knowledge regarding the specific ASF virus (ASFV) antigens involved in protection.
Accensi, Francesc, Bosch-Camós, Laia, Carrascal, Montserrat, Collado, Javier, Correa-Fiz, Florencia, Domínguez, Javier, López, Elisabet, Navas, María Jesús, Nikolin, Veljko, Park, Chankyu, Pina-Pedrero, Sonia, Rodríguez, Fernando, Salas, Maria Luisa   +12 more
core   +1 more source

Cross-protection against African swine fever virus upon intranasal vaccination is associated with an adaptive-innate immune crosstalk [PDF]

, 2022
African swine fever virus (ASFV) is causing a worldwide pandemic affecting the porcine industry and leading to important global economic consequences. The virus causes a highly lethal hemorrhagic disease in wild boars and domestic pigs. Lack of effective
Accensi, Francesc, Alonso, Uxía, Argilaguet, Jordi, Bataklieva, Stanimira, Bosch Camós, Laia, Caratù, Ginevra, Chang, Chia-Yu, Dabad, Marc, Esteve-Codina, Anna, Gavrilov, Boris, Liu, Lihong, Martín-Mur, Beatriz, Muñoz, Marta, Navas, María J., Pina-Pedrero, Sonia, Pleguezuelos, Patricia, Rodriguez, Fernando, Salas, María L., Vidal, Enric   +18 more
core   +7 more sources

Deletion Mutants of the Attenuated Recombinant ASF Virus, BA71ΔCD2, Show Decreased Vaccine Efficacy [PDF]

, 2021
African swine fever (ASF) has become the major threat to the global swine industry. Lack of available commercial vaccines complicates the implementation of global control strategies. So far, only live attenuated ASF viruses (ASFV) have demonstrated solid
Accensi Alemany, Francesc, Alonso, Uxia, Anachkov, Nikolay, Argilaguet, Jordi, Borca, Manuel V., Bosch Camós, Laia, Gladue, Douglas P., López Fernandez, Elisabet, Muñoz, Marta, Navas, Maria Jesus, Pina-Pedrero, Sonia, Ramirez-Medina, Elizabeth, Rodriguez, Fernando, Salas, Maria Luisa, Vuono, Elizabeth, Zhang, Jinya   +15 more
core   +3 more sources

The African Swine Fever Virus with MGF360 and MGF505 Deleted Reduces the Apoptosis of Porcine Alveolar Macrophages by Inhibiting the NF-κB Signaling Pathway and Interleukin-1β

Vaccines, 2021
African swine fever virus (ASFV) poses serious threats to the swine industry. The mortality rate of African swine fever (ASF) is 100%, and there is no effective vaccine currently available.
Qi Gao, Yunlong Yang, Weipeng Quan, Jiachen Zheng, Yizhuo Luo, Heng Wang, Xiongnan Chen, Zhao Huang, Xiaojun Chen, Runda Xu, Guihong Zhang, Lang Gong   +11 more
doaj   +1 more source

Investigation of the First African Swine Fever Outbreak in a Domestic Pig Farm in Hong Kong

Transboundary and Emerging Diseases, Volume 2023, Issue 1, 2023., 2023
In this study, we describe the epidemiological investigation of the first African swine fever (ASF) outbreak in a local domestic pig farm in the New Territories of Hong Kong in 2021. In the outbreak farm, several affected pigs presented clinical and pathological signs consistent with ASF, while the remaining pigs showed nonspecific clinical signs or ...
Yun Young Go, Jeremy H. P. Ho, Karina W. S. Tam, Maedeh Kamali, Yiwen Zhang, Candy C. Y. Lau, Song Hao Li, Michael T. Wilson, Zhihao Guo, Runsheng Li, Guoqian Gu, May P. Y. Tse, Fraser I. Hill, Carrie Batten, Amanda Corla, John Flannery, Anne Conan, Christopher J. Brackman, Dirk U. Pfeiffer, Lin-Zhu Ren   +19 more
wiley   +1 more source

In silico analysis of highly conserved cytotoxic T-cell epitopes in the structural proteins of African swine fever virus [PDF]

Veterinary World, 2021
Background and Aim: African swine fever (ASF) is a viral disease of pigs caused by ASF virus (ASFV). High mortality and the lack of available treatments have severely impacted the swine industry resulting in huge global economic losses.
Leana Rich De Mesa Herrera, Elizabeth Paulino Bisa   +1 more
doaj   +1 more source

Vaccines for African swine fever: an update [PDF]

, 2023
African swine fever (ASF) is a fatal infectious disease of swine caused by the African swine fever virus (ASFV). Currently, the disease is listed as a legally notifiable disease that must be reported to the World Organization for Animal Health (WOAH ...
Haojie Zhang, Hongliang Zhang, Hu Shan, Saisai Zhao, Saisai Zhao, Xiulei Cai, Zhihua Qin   +6 more
core   +1 more source

Dynamics of Serological and Mucosal Antibody Responses against African Swine Fever Viruses in Experimentally Infected Pigs

Transboundary and Emerging Diseases, Volume 2023, Issue 1, 2023., 2023
African swine fever virus (ASFV) is a lethal swine pathogen, and there is no effective vaccine or treatment available for ASFV infection. Recently, the occurrence of ASFV genotype I and genotype II natural mutants that manifest as subacute, longer‐incubation, or persistent infections poses threats to preventing ASFV infection.
Qingyun Xie, Yun Bai, Wan Wang, Rong Chen, Huixuan Xing, Yuzi Wu, Guoqing Shao, Zhigao Bu, Dongming Zhao, Zhixin Feng, Mohsin Khurshid   +10 more
wiley   +1 more source