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An Update on African Swine Fever Virology [PDF]

Viruses, 2019
Animal diseases constitute a continuing threat to animal health, food safety, national economy, and the environment. Among those, African swine fever (ASF) is one of the most devastating viruses affecting pigs and wild suids due to the lack of vaccine or
Axel Karger, Daniel Pérez-Núñez, Jesús Urquiza, Patricia Hinojar, Covadonga Alonso, Ferdinando B. Freitas, Yolanda Revilla, Marie-Frédérique Le Potier, Maria Montoya   +8 more
doaj   +3 more sources

Molecular Characterization of African Swine Fever Viruses Circulating in Can Tho City, Vietnam

Veterinary Medicine International, 2023
African swine fever (ASF) is a highly contagious and deadly viral disease in domestic and feral pigs. Since 2018, the disease has spread and caused large socioeconomic consequences to the pig industry in several Asian countries including China, Vietnam ...
Nguyen Duc Hien, Le Trung Hoang, To My Quyen, Nguyen Phuc Khanh, Lam Thanh Nguyen   +4 more
doaj   +2 more sources

The CD2v protein of African swine fever virus interacts with the actin-binding adaptor protein SH3P7

Journal of General Virology, 2004
The predicted extracellular domain of the CD2v protein of African swine fever virus (ASFV) shares significant similarity to that of the CD2 protein in T cells but has a unique cytoplasmic domain of unknown function. Here we have shown that CD2v is expressed as a glycoprotein of approximately 105 kDa in ASFV-infected cells.
Pen C Kay-Jackson, Lynnette C. Goatley, Laura Cox, James Miskin, R. M. E. Parkhouse, Jürgen Wienands, Linda K. Dixon   +6 more
openalex   +3 more sources

Subtle Genetic Shifts of African Swine Fever Virus Among Vietnamese Domestic Swine Following Live-Attenuated Vaccine Commercialization. [PDF]

Transbound Emerg Dis
Since its first incursion in 2019, African swine fever (ASF) has remained a constant threat to the Vietnamese swine industry. The nationwide commercialization and implementation of live‐attenuated vaccines (LAVs), alongside depopulation‐repopulation efforts, necessitate a critical assessment of whether these strategies have driven inadvertent changes ...
Nguyen TC, Tantitaveewattana P, Pamornchainavakul N, Do DT, Kedkovid R, Thanawongnuwech R.   +5 more
europepmc   +2 more sources

Modulation of MHC class I expression by African swine fever virus and the role of virus proteins EP153R and CD2v

, 2016
Various DNA viruses, including pox- and herpesviruses, express proteins which downregulate host MHC class I antigen expression as an immune evasion strategy. Previous studies into whether ASFV modulates expression of the porcine MHC class I molecule, SLA-I, have not provided a clear answer. In this thesis, the effect of African swine fever virus (ASFV)
Deborah Arav
openalex   +2 more sources

Subsequent Immunization of Pigs with African Swine Fever Virus (ASFV) Seroimmunotype IV Vaccine Strain FK-32/135 and by Recombinant Plasmid DNA Containing the CD2v Derived from MK-200 ASFV Seroimmunotype III Strain Does Not Protect from Challenge with ASFV Seroimmunotype III

Vaccines, 2023
Understanding the immunological mechanisms of protection and the viral proteins involved in the induction of a protective immune response to the African swine fever virus (ASFV) is still limited.
Alexey D. Sereda, Anna S. Kazakova, Sanzhi G. Namsrayn, Mikhail E. Vlasov, Irina P. Sindryakova, Denis V. Kolbasov   +5 more
doaj   +3 more sources

A synthetic genomics-based African swine fever virus engineering platform. [PDF]

Sci Adv
African swine fever (ASF) is a deadly viral disease in domestic pigs that has a large global economic impact for the swine industry. It is present in Africa, Europe, Asia, and in the Caribbean island of Hispaniola.
Fuchs W, Assad-Garcia N, Abkallo HM, Xue Y, Oldfield LM, Fedorova N, Hübner A, Kabuuka T, Pannhorst K, Höper D, Nene V, Gonzalez-Juarbe N, Steinaa L, Vashee S.   +13 more
europepmc   +3 more sources

A triple protein-based ELISA for differential detection of ASFV antibodies [PDF]

Frontiers in Veterinary Science
African swine fever (ASF) caused by the ASF virus (ASFV) is a severe and highly contagious viral disease that poses a significant threat to the global pig industry.
Shuai Zhang, Yuzhu Zuo, Wenyuan Gu, Yunhuan Zhao, Ying Liu, Jinghui Fan, Jinghui Fan   +6 more
doaj   +2 more sources

Computational insights in CD58 binding to ASFV CD2v and in silico optimization of nanobody designs against the interface [PDF]

Open Veterinary Journal
Background: African swine fever (ASF) continues to hamper pork production worldwide. In addition to vaccines, there is a need to develop curative therapeutics, such as highly-specific antibodies or nanobodies, against immunogenic proteins with important
Albert Neil Gura Dulay, Richelle Mae Evasco Padilla, Nyzar Mabeth Obenio Odchimar, Fredmoore Legaspi Orosco   +3 more
doaj   +2 more sources

Detection of African Swine Fever Virus Genotype II in West Africa (2020) and Its Co-Circulation With Endemic Genotype I: Implications for Pig Production. [PDF]

Transbound Emerg Dis
African swine fever (ASF) is a highly devastating disease of domestic pigs caused by the ASF virus (ASFV). Historically, only ASFV Genotype I was known to circulate in West Africa. However, Genotype II has recently emerged in Nigeria, Ghana, and Benin for the first time. Between 2017 and 2023, suspected ASF outbreaks were reported in Burkina Faso, Côte
Meki IK, Adedeji AJ, Ouoba LB, Koffi YM, Diakité A, Settypalli TBK, Habibata-Zerbo L, Kouakou KV, Diakité MA, Masembe C, Sidi M, Douyeri TO, Dembelé F, Luka HE, Hamidou-Ouandaogo S, Dembelé C, Weka R, Bazimo G, Dakouo M, Olubade TA, Guitti-Kindo M, Traoré C, Gamra O, Guigma D, Sidibé CAK, Hambolu DA, Adama DD, Maïga BMDA, Ogunleye MA, Toluhi A, Maurice N, Couacy-Hymann E, Luka PD, Cattoli G, Lamien CE.   +34 more
europepmc   +2 more sources