Results 21 to 30 of about 778 (150)

Identification of Two Novel Linear B Cell Epitopes on the CD2v Protein of African Swine Fever Virus Using Monoclonal Antibodies [PDF]

Viruses, 2022
African swine fever virus (ASFV) is a highly infectious viral pathogen that endangers the global pig industry, and no effective vaccine is available thus far.
Wenting Jiang, Dawei Jiang, Lu Li, Jiabin Wang, Panpan Wang, Xuejian Shi, Qi Zhao, Boyuan Liu, Pengchao Ji, Gaiping Zhang   +9 more
doaj   +6 more sources

Expression of extracellular domain of ASFV CD2v protein in mammalian cells and identification of B cell epitopes. [PDF]

Virus Res, 2023
African swine fever virus (ASFV), a highly pathogenic large DNA virus, is the cause of African swine fever worldwide. The ASFV virulence gene EP402R encodes CD2v, a structural protein that plays an important role in the ASFV infection process. In this study, a CHO-S cell line stably expressing the extracellular region of CD2v was generated and ...
Liu H, Wang A, Yang W, Liang C, Zhou J, Chen Y, Liu Y, Zhou Y, Zhang G.   +8 more
europepmc   +6 more sources

In silico prediction of B- and T-cell epitopes in the CD2v protein of african swine fever virus (African swine fever virus, Asfivirus, Asfarviridae) [PDF]

Вопросы вирусологии, 2020
Introduction. African swine fever virus (ASF) is a large DNA virus that is the only member of the Asfarviridae family. The spread of the ASF virus in the territory of the Russian Federation, Eastern Europe and China indicates the ineffectiveness of ...
Ksenia A. Mima, Elena I. Katorkina, Sergey A. Katorkin, Sodnom Zh. Tsybanov, Aleksandr S. Malogolovkin   +4 more
doaj   +7 more sources

Screening of host proteins interacting with the African swine fever virus outer membrane protein CD2v [PDF]

Frontiers in Microbiology
BackgroundThe African swine fever virus (ASFV) is a highly pathogenic double-stranded DNA virus that poses a significant threat to the global swine industry.
Xiong-nan Chen, Xiong-nan Chen, Xiong-nan Chen, Gao-xi Zhu, Gao-xi Zhu, Gao-xi Zhu, Yi-xian Li, Yi-han Hao, Yi-han Hao, Yi-han Hao, Yi-fan Liang, Yi-fan Liang, Chen Hu, Ying-shuo Sun, Ying-shuo Sun, Yun-zhao Peng, Yun-zhao Peng, Xi Li, Xi Li, Xi Li, Zhao Huang, Zhao Huang, Zhao Huang, Gui-hong Zhang, Gui-hong Zhang, Gui-hong Zhang, Lang Gong, Lang Gong, Lang Gong, Ze-zhong Zheng, Ze-zhong Zheng, Ze-zhong Zheng, Ze-zhong Zheng   +32 more
doaj   +5 more sources

From structure prediction to function: defining the domain on the African swine fever virus CD2v protein required for binding to erythrocytes [PDF]

mBio
African swine fever virus (ASFV) is a high-consequence pathogen posing a substantial threat to global food security. This large DNA virus encodes more than 150 open reading frames, many of which are uncharacterized.
Ana Luisa Reis, Anusyah Rathakrishnan, Vlad Petrovan, Muneeb Islam, Lynnette Goatley, Katy Moffat, Mai Tuyet Vuong, Yuan Lui, Simon J. Davis, Shinji Ikemizu, Linda K. Dixon   +10 more
doaj   +5 more sources

Development and characterization of monoclonal antibodies against the extracellular domain of African swine fever virus structural protein, CD2v

Frontiers in Microbiology, 2022
African swine fever virus (ASFV), a DNA double-stranded virus with high infectivity and mortality, causing a devastating blow to the pig industry and the world economy. The CD2v protein is an essential immunoprotective protein of ASFV.
Siyuan Liu, Siyuan Liu, Peiyang Ding, Yongkun Du, Yongkun Du, Dongna Ren, Yilan Chen, Minghui Li, Minghui Li, Xueke Sun, Siqiao Wang, Zejie Chang, Ruiqi Li, Gaiping Zhang, Gaiping Zhang, Gaiping Zhang, Gaiping Zhang   +16 more
doaj   +6 more sources

The ASFV CD2v protein inhibits apoptosis by inducing proteasomal degradation of BimEL via activation of the TPL2-MEK-ERK signaling pathway [PDF]

Journal of Virology
African swine fever virus (ASFV) employs sophisticated regulatory strategies to manipulate host cell apoptosis, a process critical for its pathogenesis and immune evasion; however, the mechanisms underlying this process remain incompletely understood ...
Jianyu Zeng, Xin Zhang, Jingting Zhao, Qiang Li, Zhiyong Xiang, Fengyang Shi, Hua Wang, Wenlian Weng, Qiongqiong Zhou, Peng Gao, Lei Zhou, Xinna Ge, Jun Han, Xin Guo, Yongning Zhang, Hanchun Yang   +15 more
doaj   +3 more sources

Identification of a linear B-cell epitope on the African swine fever virus CD2v protein

International Journal of Biological Macromolecules, 2023
African swine fever virus (ASFV) poses a serious threat to domestic pigs and wild boars, which is responsible for substantial production and economic losses. A dominant ASFV specific linear B cell epitope that reacted with the convalescent serum was explored and identified with the help of immune informatics techniques. It is essential in understanding
Jinxing Song, Mengxiang Wang, Yongkun Du, Bo Wan, Angke Zhang, Yuhang Zhang, Guoqing Zhuang, Pengchao Ji, Yanan Wu, Gaiping Zhang   +9 more
exaly   +5 more sources

Processing and Localization of the African Swine Fever Virus CD2v Transmembrane Protein [PDF]

Journal of Virology, 2011
ABSTRACTThe African swine fever virus (ASFV)-encoded CD2v transmembrane protein is required for the hemadsorption of red blood cells around infected cells and is also required for the inhibition of bystander lymphocyte proliferation in response to mitogens.
Lynnette C. Goatley, Linda K. Dixon
exaly   +6 more sources

ASF virus replication features in the presence of recombinant proteins CD2v, pX69R and pE248R

Вопросы вирусологии, 2019
Introduction. African swine fever (ASF), sever hemorrhagic disease of swine caused by a large DNA virus of the Asfaviridae family. Since there are no effective and safe vaccines against ASF yet, it is urgent to study the functions of its proteins, which ...
A. Mazloum, I. U. Zhukov, E. B. Aronova, A. S. Igolkin, N. N. Vlasova   +4 more
doaj   +5 more sources