Development of novel monoclonal antibodies for blocking NF-κB activation induced by CD2v protein in African swine fever virus [PDF]
Frontiers in ImmunologyBackgroundCD2v, a critical outer envelope glycoprotein of the African swine fever virus (ASFV), plays a central role in the hemadsorption phenomenon during ASFV infection and is recognized as an essential immunoprotective protein.
Rongrong Fan +19 more
doaj +10 more sources
CD2v Interacts with Adaptor Protein AP-1 during African Swine Fever Infection. [PDF]
PLoS ONE, 2015 African swine fever virus (ASFV) CD2v protein is believed to be involved in virulence enhancement, viral hemadsorption, and pathogenesis, although the molecular mechanisms of the function of this viral protein are still not fully understood.
Daniel Pérez-Núñez +6 more
doaj +15 more sources
Identification of a new cell-penetrating peptide derived from the african swine fever virus CD2v protein [PDF]
Drug Delivery, 2021 The African swine fever virus (ASFV) is a huge and complex DNA virus that can lead to the acute death of pigs and cause huge losses to the global swine industry.
Shunli Yang +7 more
doaj +9 more sources
African Swine Fever Virus CD2v Protein Induces β-Interferon Expression and Apoptosis in Swine Peripheral Blood Mononuclear Cells [PDF]
Viruses, 2021 African swine fever (ASF) is a hemorrhagic disease of swine characterized by massive lymphocyte depletion in lymphoid tissues due to the apoptosis of B and T cells, a process likely triggered by factors released or secreted by infected macrophages.
Sabal Chaulagain +3 more
doaj +9 more sources
Identification of Linear B Cell Epitopes on CD2V Protein of African Swine Fever Virus by Monoclonal Antibodies [PDF]
Microbiology Spectrum, 2022 The CD2-like (CD2V) protein is a crucial antigen of African swine fever virus (ASFV). CD2V interacts with the cellular AP-1 protein, participates in intracellular transport of virus, and induces neutralizing antibodies to partly protect swine from virus ...
Rui Jia +10 more
doaj +7 more sources
Mammalian Cell-Line-Expressed CD2v Protein of African Swine Fever Virus Provides Partial Protection against the HLJ/18 Strain in the Early Infection Stage [PDF]
Viruses, 2023 A cell line expressing the CD2v protein of ASFV was generated. The efficient expression of CD2v protein was determined by immunofluorescence and Western blotting. The CD2v protein was Ni-affinity purified from the supernatant of cell cultures.
Rong-Hong Hua +7 more
doaj +8 more sources
A protective multiple gene-deleted African swine fever virus genotype II, Georgia 2007/1, expressing a modified non-haemadsorbing CD2v protein [PDF]
Emerging Microbes and Infections, 2023 African swine fever virus is a complex DNA virus that causes high fatality in pigs and wild boar and has a great socio-economic impact. An attenuated genotype II strain was constructed by replacing the gene for wildtype CD2v protein with versions in ...
Anusyah Rathakrishnan +9 more
doaj +8 more sources
The recombinant pseudorabies virus expressing African swine fever virus CD2v protein is safe and effective in mice [PDF]
Virology Journal, 2020 Background African swine fever (ASF) leads to high mortality in domestic pigs and wild boar and is caused by the African swine fever virus (ASFV). Currently, no vaccine is commercially available for prevention, and the epidemic is still spreading.
Zhihua Feng +6 more
doaj +8 more sources
The CD2v protein of African swine fever virus inhibits macrophage migration and inflammatory cytokines expression by downregulating EGR1 expression through dampening ERK1/2 activity [PDF]
Veterinary Research, 2023 African swine fever virus (ASFV) is a highly contagious and deadly virus that leads to high mortality rates in domestic swine populations. Although the envelope protein CD2v of ASFV has been implicated in immunomodulation, the molecular mechanisms ...
Min Zhang +12 more
doaj +8 more sources
An Intracellular Epitope of ASFV CD2v Protein Elicits Humoral and Cellular Immune Responses [PDF]
Animals, 2023 The African swine fever virus (ASFV) causes high mortality in domestic pigs. ASFV encodes an important protein target for subunit vaccine development, CD2v, but its most effective immunological regions are not known.
Wenlong Lu +11 more
doaj +6 more sources