Results 141 to 150 of about 389,148 (301)
CD2 and CD3 antigens mobilize Ca2+ independently.
, 1986 Antigen-induced stimulation of T cells is mediated via the CD3 antigen receptor (Ti) complex and monoclonal antibodies (mAb) reacting with CD3 and Ti result in rapid intracellular Ca2+ mobilization, followed by monocyte-dependent proliferation ...
Mahmood Russul‐Saib +13 more
core +1 more source
Advanced Science, EarlyView.Antigenic peptides Aβ42 and E7 self‐assemble into nanofibrils; APTES and TEOS induce SiO2 NP formation on these fibrils to form SiO2@fibril nanovaccines, which activate BMDCs in vitro. In vivo, SiO2@Aβ42 fibril nanovaccines alleviate AD symptoms and clear Aβ42 plaques in APP/PS1 mice, and SiO2@E7 fibril nanovaccines inhibit tumor growth and promote ...
Xuecheng Yang +6 more
wiley +1 more source
Advanced Science, EarlyView.A nanobiohybrid vaccine was designed by constructing a hydrogen‐bonded organic framework coencapsulated with glucose oxidase (GOx) and tumor antigens. This nanobiohybrid vaccine executed a GOx‐catalyzed enzyme reaction that disrupted glucose metabolism and induced redox imbalance in dendritic cells, leading to autophagy‐dependent antigen cross ...
Weidong Wang +5 more
wiley +1 more source
外周血CD3+CD45+T细胞在原发性肝癌患者中的表达及意义
Zhongguo shiyan zhenduanxue, 2006 目的探讨原发性肝癌（Hepatocellular Carcinoma,HCC）患者外周血中CD3+CD56+T细胞、CD3+CD56-T细胞、CD3-CD56+NK细胞在（HCC）细胞免疫中所发挥的作用。方法采用流式细胞技术对14例HCC患者及30例健康对照人群外周血中的CD3+CD56+T细胞、CD3+CD56-T细胞、CD3-CD56+NK细胞进行检测。结果14例HCC患者与30例正常对照组外周血测定结果比较发现:HCC患者外周血中CD3+CD56-明显降低,CD3+CD56+则明显升高 ...
宋海澄, 宋丁, 姚树坤, 崔刘福
doaj
Alteration of gene expression profile in CD3+ T-cells after downregulating MALT1
, 2018 Xu Wang,1,2,* Shuai Lu,1,2,* Yankai Xiao,1,2 Ling Xu,2,3 Lingling Zhou,1,2 Junyan Hu,2 Bo Li,1,2 Chengwu Zeng,1,2 Yangqiu Li1–3 1Key Laboratory for Regenerative Medicine of Ministry of Education, Jinan University, Guangzhou, 510632, People’s ...
Xu L +8 more
core
, 2013 Graphs illustrate total CD3+, Total CD56+ and CD3+CD56− T cell populations (expressed as a percentage of the lymphogate) in patients maintaining or withdrawing therapy at baseline (▴) and three months ...
Elizabeth J. Ryan (339092) +7 more
core +1 more source
Rewiring Pyroptosis to Potentiate Cancer Immunotherapy via a Gasdermin D Agonist Bypassing Caspase‐3
Advanced Science, EarlyView.This work introduces a small‐molecule agonist, DIBDO, that bypasses Casp‐3 to directly trigger GSDMD‐mediated pyroptosis in tumors. Activated by glutathione, DIBDO generates singlet oxygen and molecular iodine, blocking Casp‐3 pathways and inducing immunogenic cell death.
Dan Zhao +6 more
wiley +1 more source
Advanced Science, EarlyView.In MYC‐enforced B‐cell lymphoma, SOX5 occupies promoter‐proximal regulatory regions and is associated with reduced chromatin accessibility at the PCNP locus. PCNP repression promotes proliferative remodeling by limiting apoptosis and cell‐cycle restraint.
Yiyou Mao +6 more
wiley +1 more source
, 2012 The dynamics of the O(D-1) + CD4 -> OD + CD3 reaction has been studied using the crossed molecular beam technique with sliced velocity map imaging. Internally excited CD3 products were detected using a (2+1) resonance-enhanced multiphoton ionization with
Zhang, Dong +6 more
core +1 more source
Advanced Science, EarlyView.A supramolecular pyroptotic thermal switch encapsulates I3− within β‐cyclodextrin (β‐CD) and undergoes CaCO3 mineralization. Upon lysosomal acidification, CaCO3 is degraded, releasing Ca2+ and I3−. Concurrently, BODIPY activation converts I3− into I2, inducing oxidative stress and Ca2+ overload, which together trigger caspase‐3/GSDME‐mediated ...
Dan Wu +8 more
wiley +1 more source