Results 121 to 130 of about 389,148 (301)

WT1‐Targeted Oral Bifidobacterium longum Vaccine Enhances Checkpoint Blockade Efficacy in Pancreatic Cancer

Advanced Science, EarlyView.
Oral WT1‐targeted Bifidobacterium longum vaccine promotes WT1‐associated cellular immunity and enhances anti‐PD‐1/anti‐CTLA‐4 efficacy in pancreatic cancer. ABSTRACT Pancreatic ductal adenocarcinoma (PDAC) remains largely unresponsive to immune checkpoint inhibitors (ICI) due to its profoundly immunosuppressive tumor microenvironment.
Taiki Yamazaki, Aori Minami, Misako Hirota, Mirei Hirano, Ryota Sato, Atsuki Honma, Hideto Ueki, Toshiro Shirakawa   +7 more
wiley   +1 more source

Infiltration of CD3⁺ and CD68⁺ cells in bladder cancer is subtype specific and affects the outcome of patients with muscle-invasive tumors.

Urologic oncology, 2014
OBJECTIVES Urothelial carcinoma (UC) aggressiveness is determined by tumor inherent molecular characteristics, such as molecular subtypes, as well as by host reactions directed toward the tumor.
G. Sjödahl, Kristina Lövgren, M. Lauss, G. Chebil, O. Patschan, S. Gudjonsson, W. Månsson, M. Fernö, K. Leandersson, D. Lindgren, F. Liedberg, M. Höglund   +11 more
semanticscholar   +1 more source

Apoptosis under CD3/CD28 stimulation.

, 2013
A. Representative plots demonstrating upregulation of CD25 in response to CD3/CD28 stimulation in mixed splenocyte cultures. B. Spontaneous apoptosis in isolated (n = 4) and gated cells (n = 5) in reference to responsiveness (CD25 expression) to CD3 ...
Enosh M. Askenasy (349060), Ayelet Kaminitz (349057), Jerry Stein (349062), Isaac Yaniv (349064), Nadir Askenasy (349066)   +4 more
core   +1 more source

Tumor-Infiltrating CD3- NK Cells Are More Effective than CD3+ T Cells in Killing Autologous Melanoma Cells [PDF]

, 1991
We have studied the phenotype and functional activity of tumor-infiltrating lymphocytes (TIL) derived from eight human melanomas cultured for up to 60 d in the presence of recombinant IL-2.
Prade, Michael, Azogui, Orly, Margulis, Alvaro, Guillard, Maryvonne, Caillou, Bernard, Avril, Marie-Françoise   +5 more
core   +1 more source

Targeting p21‐High Senescent Kupffer Cells Nanotherapeutically Potentiates Antitumor Immunity in Advanced Hepatocellular Carcinoma with Portal Vein Tumor Thrombus

Advanced Science, EarlyView.
Schematic illustration of a biomimetic SKEV@AAV platform targeting p21‐high senescent Kupffer cells (sKCs) in hepatocellular carcinoma (HCC) with portal vein tumor thrombus (PVTT). p21‐high sKCs accumulate in the PVTT microenvironment and establish an immunosuppressive, SASP‐rich environment that facilitates tumor cell proliferation and immune evasion.
Na Ta, Shuyi Wang, Boyan Zhang, Ning Liu, Yingchen Han, Aoran Liu, Ying Xu, Tingsong Chen, Ye Zhang, Qiuhua Luo, Tao Han   +10 more
wiley   +1 more source

CD3-negative lymphokine-activated cytotoxic cells express the CD3 epsilon gene.

, 1988
The expression of genes encoding different polypeptide chains of the TCR-CD3 complex was analyzed in a panel of cloned MHC-unrestricted cytotoxic cells. The clones were derived from CD3+ and CD3- human PBL.
Prigione I, MORETTA, ALESSANDRO, Biassoni R, Long EO, Ferrini S   +4 more
core   +1 more source

Mucoadhesive Peptide‐Catalase Self‐Assembled Nano‐Formulation for Effective Treatment of Mucosal Inflammatory Diseases

Advanced Science, EarlyView.
CR8L10 is self‐assembled with catalase (CAT) to form CR8L10@CAT nanocomplexes, which can anchor to mucosal surfaces via thiol‐disulfide exchange with mucin, thereby enhancing their mucosal retention. The efficient reactive oxygen species (ROS) scavenging at inflamed sites would then result in successful treatment in both the intravesical IC/BPS model ...
Xinzhu Li, Yuxuan Ma, Di He, Yingying Huang, Yutong Jiang, He Zhao, Shengjie Ge, Ruirui Zhao, Hejia Yuan, Wendi Jiang, Wenjun Zhu, Kai Liu, Han Zhang, Zhuang Liu   +13 more
wiley   +1 more source

The CD3 conformational change in the γδ T cell receptor is not triggered by antigens but can be enforced to enhance tumor killing.

Cell Reports, 2014
Activation of the T cell receptor (TCR) by antigen is the key step in adaptive immunity. In the αβTCR, antigen induces a conformational change at the CD3 subunits (CD3 CC) that is absolutely required for αβTCR activation.
E. Dopfer, Frederike A. Hartl, H. Oberg, Gabrielle M. Siegers, O. S. Yousefi, S. Kock, Gina J. Fiala, Beatriz Garcillán, A. Sandstrom, B. Alarcón, J. Regueiro, D. Kabelitz, E. Adams, Susana Minguet, D. Wesch, P. Fisch, W. Schamel   +16 more
semanticscholar   +1 more source

Mechanochemical Piezoelectric Catalysis: Advancing the Hydrogenation of Alkenes

Advanced Science, EarlyView.
This study presents mechanochemical piezoelectric catalysis for alkene hydrogenation, eliminating the need for transition metals, H2, and solvents. The method effectively hydrogenates diverse activated and unactivated alkenes and shows potential for modifying bioactive molecules in pharmaceuticals.
Zixi Ai, Mengting Liu, Xiaohong Wang, Xiaochun He, Xuemei Zhang, Zhong Lian   +5 more
wiley   +1 more source

The role of changes in adaptive immunity as a factor of unfavorable outcome in abdominal sepsis

Медицинская иммунология
Altered immune response in abdominal sepsis (AS) leads to dysregulation of innate and adaptive immunity, followed by immunosuppression. Mortality rates in AS are quite high, thus requiring continued indepth study of the role of adaptive immunity in this ...
M. V. Osikov, L. F. Telesheva, A. G. Konashov, V. A. Konashov, A. V. Gusev, M. S. Boyko, V. A. Sumerkina, A. A. Minasova   +7 more
doaj   +1 more source