Results 101 to 110 of about 389,148 (301)

A tetravalent bispecific TandAb (CD19/CD3), AFM11, efficiently recruits T cells for the potent lysis of CD19+ tumor cells

mAbs, 2015
To harness the potent tumor-killing capacity of T cells for the treatment of CD19+ malignancies, we constructed AFM11, a humanized tetravalent bispecific CD19/CD3 tandem diabody (TandAb) consisting solely of Fv domains.
U. Reusch, J. Duell, Kristina Ellwanger, Carmen Herbrecht, S. Knackmuss, Ivica Fucek, Markus Eser, F. McAleese, V. Molkenthin, F. Le Gall, M. Topp, M. Little, E. Zhukovsky   +12 more
semanticscholar   +1 more source

APPLICATION OF SIX-COLOR FLOW CYTOMETRIC ANALYSIS FOR IMMUNE PROFILE MONITORING

Медицинская иммунология, 2015
The article deals with applications of six-color flow analysis for studying the immune state parameters by means of flow cytometry. Whole blood from healthy donors was stained with combination of monoclonal antibodies, i.e., HLA-DR-FITC, CD16+56-PE, CD4 ...
I. V. Kudryavtsev, A. I. Subbotovskaya
doaj   +1 more source

Zmiany ilościowe populacji limfocytów CD3+ i CD45RA+ we krwi szczurów poddanych działaniu wolnozmiennego pola elektromagnetycznego [PDF]

, 2007
It was reported that an extremely low frequency (ELF) electromagnetic field causes biological effects in vitro and in vivo. The major functions of the immune system are to develop the concept of "self" and eliminate what is "non-self". In our preliminary
Salwiczek, Anna, Ślusarczyk, Konstanty, Arendt, Jerzy, Drzazga, Zofia, Mazur, Bogdan, Królak-Olejnik, Barbara, Król, Wojciech, Beck, Brygida, Cholewka, Armand   +8 more
core  

Analysis of IFNG expression in CD3+ and CD3- cell subsets.

, 2015
PBMC from LTBI+ donors were stimulated with PPD or left unstimulated, stained with antibodies against surface markers as indicated, probed with Cy5-labeled IFNG probes, and analyzed by flow cytometry.
Riccardo Arrigucci (836859), Sanjay Tyagi (8954), Alfred Lardizabal (836863), Richard Pine (836862), Maria Laura Gennaro (836864), Yuri Bushkin (33972), Karim Lakehal (836860), Pooja Vir (836858), Amy L. Davidow (836861)   +8 more
core   +1 more source

Mitochondria and Neuromast Tagging With Fluorescent Gallium‐Triapine Analogues: In Cellulo MP FLIM and Zebrafish Live Imaging

Advanced Science, EarlyView.
Fluorescent BODIPY‐conjugated thiosemicarbazone ligands and their Ga(III), In(III), and Fe(III) complexes, inspired by Triapine, are developed as theranostic agents. Multiphoton FLIM and confocal microscopy in cancer cells and zebrafish reveal real‐time uptake, mitochondrial localisation, and whilst spectroscopic assays indicated preserved complex ...
Megan J. Green, Michael W. Jones, Merissa Saleem, Haobo Ge, Melita Tvardauskaite, Julia Dudzic, Fernando Cortezon‐Tamarit, Rory L. Arrowsmith, Charareh Pourzand, Gabriele Kociock‐Kohn, Nicholas H. Rees, Jonathan R. Dilworth, Stephen Faulkner, Stanley W. Botchway, David Gurevich, Sofia I. Pascu   +15 more
wiley   +1 more source

Dynamic assessment of T-lymphocytes and humoral immunity in patients with acute coronary syndrome, with and without COVID-19, depending on the content of CD3⁺CD8⁺T-lymphocytes

Медицинский вестник Юга России
Objective: to evaluate the dynamics of the T- and B-cell immunity in patients with acute coronary syndrome (ACS) who have and have not had COVID-19, depending on the number of CD3+CD8+T-lymphocytes.Materials and methods: 65 men with ACS who underwent ...
E. A. Safronova, L. V. Ryabova, A. V. Zurochka, M. A. Dobrynina, E. V. Zadorina   +4 more
doaj   +1 more source

Combating Inflammation and Promoting Anabolism in Osteoarthritic Cartilage Defect With an MMP13‐Sensing Dual‐Drug Scaffold

Advanced Science, EarlyView.
ABSTRACT Osteoarthritis (OA) is a widespread degenerative joint condition marked by progressive cartilage breakdown, and a chronic inflammatory microenvironment, where conventional therapies largely fail to halt disease progression. To address this unmet need, an intra‐articularly implantable, disease‐responsive scaffold was developed for combinatorial
Zhen Zhang, Bangheng Liu, Yulei Mu, Huiqun Zhou, Liang Ma, Chenjie Xu, Dong‐An Wang   +6 more
wiley   +1 more source

Identification of the Docking Site for CD3 on the T Cell Receptor β Chain by Solution NMR*

Journal of Biological Chemistry, 2015
Background: Understanding T cell signaling requires knowing the structure of the TCR-CD3 complex. Results: Solution NMR was used to identify the docking site for CD3 ectodomains on the TCR β chain.
Yanan He, S. Rangarajan, M. Kerzic, M. Luo, Yihong Chen, Qian Wang, Yi-Yuan Yin, C. Workman, Kate M Vignali, D. Vignali, R. Mariuzza, J. Orban   +11 more
semanticscholar   +1 more source

Frequency of RORγt and T-bet expression in CD3⁺, CD3⁺CD4⁺, CD3⁺CD8⁺ lymphocytes.

, 2019
A-G. Expression of transcription factors RORγt and T-bet in CD3+, CD3+CD4+, and CD3+CD8+ Lymphocytes and in CD3+ Naive (N), Central Memory (CM), Effector Memory (EM), and Terminally Differentiated (TD) Cells. Co-expression of T-bet in CD3+, CD3+CD4+, and
Thomas Ryan (6196559), Brian O’Connell (1888420), Ana Moreno-Olivera (7553411), Alhanouf I. Al-Harbi (7553414), Derek G. Doherty (7553420), Ross McManus (23779), Eamon P. Breen (4583362), John D. Coakley (7553408), Ashanty M. Melo (7553417)   +8 more
core   +1 more source

Engineering Immunoregenerative Therapy via an Immunomodulatory Binary Pharmacology Hydrogel Depot for Prolonged Allograft Survival

Advanced Science, EarlyView.
An immunomodulatory hydrogel (iGEL) forms spontaneously upon subcutaneous injection, acting as a tissue‐adhesive depot. It releases anti‐rejection and regenerative agents in response to inflammation, suppressing T‐cell activity, promoting vascular repair, and restoring allograft function without systemic immunosuppression.
Ning Wang, Ruiqi Sun, Yang Fu, Zhonghan Wu, Xinyu Tong, Hong Tang, Wentao Zhao, Zhi Liang, Jintao Zheng, Yanan Guan, Ke Zhou, Penghong Song, Shusen Zheng, Hangxiang Wang, Haiyang Xie   +14 more
wiley   +1 more source