Results 81 to 90 of about 389,148 (301)

Phenotype of Peripheral Blood Leukocytes and Survival of Patients with Metastatic Colorectal Cancer

The International Journal of Biological Markers, 2005
Immune dysfunction is prevalent in metastatic cancer. Few patients with colorectal cancer metastases are cured, and among the strategies aimed at improving the therapeutic results in patients with metastatic colorectal cancer, immunotherapy is being ...
P. Veselý, M. Touškoví, B. Melichar MD, PhD   +2 more
doaj   +1 more source

Expression and function of a variant T cell receptor complex lacking CD3-gamma.

, 1991
A T cell line termed DIL2 has been derived from an infant with a polyclonal T cell receptor (TCR)/CD3 cell surface expression defect. Indirect immunofluorescence showed that the expression of certain TCR/CD3 epitopes (like those detected by WT31 and ...
Regueiro González-Barros, José Ramón, Terhorst, Cox, Alarcon, Balbino, ArnaizVillena, Antonio, M Timón, P Pérez-Aciego, O G Segurado, B Alarcón, Timon, Marcos, Segurado, Oscar, A Arnaiz-Villena, J R Regueiro, C Terhorst, Perez Aciego, Paloma, Arnaiz Villena, Antonio   +14 more
core   +1 more source

Lignin Mimicking Protein Methylation Augments the Efficacy of FOLFOX Chemotherapy by Anchoring Thymidylate Synthase

Advanced Materials, EarlyView.
Lignin‐mimicking protein methylation can enhance the efficacy and mitigate the toxicity of the classic FOLFOX chemotherapy regimen. ABSTRACT FOLFOX has served as the standard chemotherapy regimen for advanced stages, specifically in the treatment of pancreatic, colorectal, and bladder cancers.
Shiyao Song, Yan‐Lai Tang, Xiaoting Liu, Jiayi Zheng, Chong Wu, Tang Li, Junhong Ye, Dianmin Xia, Yong Mei, Jingxuan Ma, Libin Huang, Xuequn Luo, Liheng Chen, Yanlin Qin, Weiling He   +14 more
wiley   +1 more source

Immunoscore encompassing CD3+ and CD8+ T cell densities in distant metastasis is a robust prognostic marker for advanced colorectal cancer

OncoTarget, 2016
Background The immunoscore (IS), an index based on the density of CD3+ and CD8+ tumor-infiltrating lymphocytes (TILs) in the tumor center (CT) and invasive margin (IM), has gained considerable attention as a prognostic marker.
Y. Kwak, Jiwon Koh, Duck-Woo Kim, Sung-Bum Kang, W. Kim, H. Lee   +5 more
semanticscholar   +1 more source

Intra-tumoral lymphocyte scoring in colorectal cancer: improving prognostic utility and correlation with underlying cancer biology

Frontiers in Gastroenterology
BackgroundIntra-tumoral lymphocytes hold prognostic and predictive significance in colorectal cancer (CRC). The internationally validated Immunoscore™ predicts CRC survival risk by averaging percentile scores of tumor-associated CD3+ and CD8+ cell ...
Patrick L. Wagner, Jianwu Xie, Devin C. Flaherty, Hyun Park, Chelsea Knotts, Justine Debelius, Curtis Tilves, Neda Dadgar, Kunhong Xiao, Ali H. Zaidi, Louis Gil Acevedo, William LaFramboise, Ni Zhao, Cynthia Sears, Noel Mueller   +14 more
doaj   +1 more source

Ionizable Lipid‐Dependent Optimization of Steroid Lipid Nanoparticles With Tunable Immunomodulatory Properties

Advanced Materials, EarlyView.
A novel engineering strategy that establishes material design principles for incorporating anti‐inflammatory steroids into lipid nanoparticles to reduce LNP‐induced inflammation while retaining mRNA delivery. Results are validated in vitro and in three animal models of inflammation and autoimmunity in vivo.
Ajay S. Thatte, Benjamin E. Nachod, Julia Baena, Jenna Muscat‐Rivera, Lesley Chaboub, Hannah C. Safford, Hannah C. Geisler, Hannah M. Yamagata, Melgious J. Y. Ang, Michael Kegel, Alexandre Poirier, Elaine R. Tong, Zhe Zhong, Qiangqiang Shi, Jinjin Wang, Elisa Battistini, Ye Zeng, Alex G. Hamilton, Kelsey L. Swingle, Drew Weissman, Jilian R. Melamed, Michael J. Mitchell   +21 more
wiley   +1 more source

Sensitivity to apoptosis under CD3 and CD3/CD28 stimulation.

, 2013
A. Representative plots of CD25 upregulation under CD3 stimulation in splenocytes from NOD and wild type mice. Quantitative conversion to express CD25 in splenocyte cultures from NOD (n = 4) and wild type females (n = 6) under CD3 and CD3/CD28 ...
Enosh M. Askenasy (349060), Ayelet Kaminitz (349057), Jerry Stein (349062), Esma S. Yolcu (299557), Isaac Yaniv (349064), Haval Shirwan (299564), Nadir Askenasy (349066)   +6 more
core   +1 more source

Anisotropic Masked Mycobacterium Potentiates Amplified Antitumor Trained Immunity via Spleen Targeting and Myelopoiesis Conversion

Advanced Materials, EarlyView.
An engineered Trojan Mycobacterium, developed via a “peeling‐off and masking‐up” strategy, functions as a powerful splenic myelopoiesis converter. This spleen‐targeted nanomedicine induces trained immunity to reprogram immunosuppressive myeloid reservoirs into antitumoral effectors.
Jin‐Ho Choi, Sang Nam Lee, Jang Hun Heo, Soyoung Park, Sei Hyun Park, Yong Taik Lim   +5 more
wiley   +1 more source

CD3+ T-cell subsets and CD3+CD4+ T-cell responses to SARS-CoV-2 spike protein.

, 2022
(A) C3+CD4+ and CD3+CD4+ T-cell frequencies depicted per patient, MIS-C classification, ICU stay and age. (B) CD4+/CD8+ ratios in MIS-C and KD patients (C) CD4+/CD8+ ratios in relation to ICU stay (D) Representative flow cytometry contour plots of CD3 ...
T. H. M. Ottenhoff (9081397), D. van Stijn (14197476), D. Schonenberg-Meinema (7346594), I. M. Kuipers (14197470), G. Biesbroek (14197464), H. Scherpbier (14197512), E. G. J. von Asmuth (14197494), M. van der Kuip (14197491), M. H. A. Jansen (14197485), K. E. van Meijgaarden (14197515), J. M. van den Berg (14197536), H. L. Zaaijer (14197530), M. P. Gruppen (14197473), B. Kapitein (14197467), T. E. Peros (14197479), M. G. Mooij (14197497), N. Ketharanathan (14197521), M. Blink (14197524), P. Hombrink (14197533), G. W. Landman (14197503), M. Boele van Hensbroek (14197509), A. M. Tutu van Furth (14197506), M. E. J. den Boer (14197500), M. A. van Houten (11823314), S. A. Joosten (14197518), E. P. Buddingh (14197539), T. W. Kuijpers (7638836), M. van Veenendaal (14197482), C. L. H. Brackel (14197527), C. W. van der Zee (14197488)   +29 more
core   +1 more source

Membrane‐Bound Multimodal Plasmonic Transducers for Noninvasive, In Situ Monitoring and Control of CAR T Cells Against Heterogeneous Solid Tumors

Advanced Materials, EarlyView.
Membrane‐bound multimodal transducers enable longitudinal ultrasound‐guided photoacoustic monitoring and in situ thermal control of CAR T cells in heterogeneous solid tumors. Imaging correlates T cell trafficking with tumor response, distinguishing responders from nonresponders.
Myeongsoo Kim, Ali Zamat, Melissa Cadena, Chloé Thiveaud, Riya Sen, Jeungyoon Lee, Elif Kulaksizoglu, S. Abbey Oliver, Don VanderLaan, Sydney Fábrega, Zizhen Zha, Kelsey P. Kubelick, Jinhwan Kim, Gabriel A. Kwong, Stanislav Y. Emelianov   +14 more
wiley   +1 more source