Results 71 to 80 of about 389,148 (301)

Multifunctional Neutrophil Nanovesicles Induce Remodeling of Tumor Immune Microenvironment and Synergistic Multimodal Tumor Therapy

open access: yesAdvanced Functional Materials, EarlyView.
Schematic illustration of the engineered RN@FDT for multimodal tumor therapy. a) Fabrication of FD&DOX/TFA‐loaded RGD‐NNV (RN@FDT) and the light‐triggered disassemble of RN@FDT. b) After internalized by tumor cells, RN@FDT are disintegrated under NIR‐II laser irradiation to boost PTT and induce cell apoptosis.
Jiahui Zhang   +16 more
wiley   +1 more source

The T cell antigen receptor α transmembrane domain coordinates triggering through regulation of bilayer immersion and CD3 subunit associations

open access: yesImmunity, 2018
&NA; Initial molecular details of cellular activation following &agr;&bgr;T cell antigen receptor (TCR) ligation by peptide‐major histocompatibility complexes (pMHC) remain unexplored.
K. Brazin   +14 more
semanticscholar   +1 more source

Phenotypic and functional analyses of NK and NKT-like populations during the early stages of chikungunya infection

open access: yesFrontiers in Microbiology, 2015
The aim of this study was to characterize NK (CD56+CD3−) and NKT-like cell (CD56+CD3+) responses early after chikungunya infection. Expression profiling and functional analysis of T/NK/NKT-like cells were performed on samples from 56 acute and 31 ...
Subrat eThanapati   +2 more
doaj   +1 more source

The percentages of CD3+, CD3+CD4+, CD3+CD8+in each group (M ± SD, n = 6, unit = %).

open access: yes, 2018
The percentages of CD3+, CD3+CD4+, CD3+CD8+in each group (M ± SD, n = 6, unit = %).
Guizhou Yue (1419832)   +19 more
core   +1 more source

The impact of CD3+ TILs infiltration.

open access: yes, 2023
a: The number of infiltrating CD3+ TILs. b, c: IHC staining with CD3 antibody. b: low infiltration, c: high infiltration. d: overall survival and recurrence-free survival for CD3+ TILs.
Shoji Kubo (3761827)   +9 more
core   +1 more source

Comprehensive In Vitro Profiling Demonstrates Successful Immune Evasion of Bioengineered Immune‐Shielded Heart Valves

open access: yesAdvanced Healthcare Materials, EarlyView.
Living donor heart valves offer superior durability for pediatric patients but trigger immune rejection. Lentiviral delivery of viral immune‐evasion genes US2 and Serpin b9 into donor valve cells and valve tissue suppresses HLA expression, reduces PBMC clustering and cytotoxic killing, and induces transcriptional immune‐tolerance programs, paving the ...
Abraham van Wijk   +11 more
wiley   +1 more source

Therapeutic anti-CD3 monoclonal antibodies: from bench to bedside.

open access: yesImmunotherapy, 2016
The induction of tolerance is a major goal of immunotherapy. Investigations over the last 20 years have shown that anti-CD3 monoclonal antibodies (mAbs) effectively treat autoimmune disease in animal models and have also shown promise in clinical trials.
C. Kuhn, H. Weiner
semanticscholar   +1 more source

Lymphocyte and CD62E expression in lichen planus and lichenoid reaction

open access: yesBMC Oral Health, 2022
Background It is difficult to distinguish the clinical and histopathological aspects of oral lichen planus lesions from those of oral lichenoid reaction.
Juliana Tristão Werneck   +3 more
doaj   +1 more source

Near‐Infrared Light‐Activated Polydopamine Nanoparticles Conjugated With Transferrin Peptides for Enhanced Brain Accumulation

open access: yesAdvanced Healthcare Materials, EarlyView.
This study demonstrates that Tf‐PDA NPs combine a receptor‐mediated targeting with mild photothermal activation to enhance nanoparticle accumulation in the brain. NIR‐activated Tf‐PDA NPs increase BBB permeability to NPs in vitro and in vivo without inducing cytotoxicity or adverse immune responses.
Rafaela Ferrão   +5 more
wiley   +1 more source

Novel anti-CD3 chimeric antigen receptor targeting of aggressive T cell malignancies

open access: yesOncoTarget, 2016
Peripheral T-cell lymphomas (PTCLS) comprise a diverse group of difficult to treat, very aggressive non-Hodgkin's lymphomas (NHLS) with poor prognoses and dismal patient outlook.
Kevin H. Chen   +10 more
semanticscholar   +1 more source

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