Results 261 to 270 of about 389,148 (301)

Targeting the NR1D1–IGF2BP2–V‐ATPase Axis With Hybrid Nanovesicles Restores Macrophage Rhythms to Reverse Sepsis‐Induced Immunosuppression

Advanced Science, EarlyView.
Sepsis disrupts immune‐cell rhythms and weakens bacterial clearance. Biomimetic nanovesicles combining erythrocyte and inflammation‐activated macrophage membranes deliver siNR1D1 to dysfunctional macrophages, restoring the NR1D1–IGF2BP2–V‐ATPase pathway, circadian regulation, phagolysosomal acidification, and antimicrobial defense.
Lang Chen, Wenyi Lin, Lang Jiang, Xuehui Gao, Chenyan Yu, Jili Han, Zhenping Liu, Xuefeng Li, Mei He, Chang Li, Qilan Li, Chaoying Song, Jiqian Xu, You Shang   +13 more
wiley   +1 more source

Ocular manifestations and immunological profiles of thyroid eye disease with lacrimal gland enlargement. [PDF]

Front Endocrinol (Lausanne)
Sun Y, Shi F, Wang C, Dong X, Su Y, Yu F, Hong S, Wu D, Zou M, Yang Z, Xiao H, Wan P.   +11 more
europepmc   +1 more source

In Vivo Direct Reprogramming: Current Progress and Future Prospects from Mechanisms to Therapeutic Application

Advanced Science, EarlyView.
This review examines the potential of in vivo direct reprogramming in regenerative medicine for functional tissue restoration, highlighting the role of tissue‐resident cues in generating functionally mature reprogrammed cells from lineage‐related cells. It contains a discussion on mechanisms, reprogramming factors, delivery approaches, and applications
Rishabh Deo Singh, Mauro Calvoli, Kyeong Kyu Kim   +2 more
wiley   +1 more source

Mucosal regulatory and effector T-cell imbalance in CVID-associated enteropathy. [PDF]

Front Immunol
Demir S, Kahveci N, Gelmez MY, Unal D, Yegit OO, Yagli MA, İstemihan Z, Berker N, Cavus B, Besisik F, Cetin Aktas E, Gelincik A, Deniz G.   +12 more
europepmc   +1 more source

Predictive value of peripheral lymphocyte subsets in relation to opportunistic infections in people living with HIV/AIDS. [PDF]

BMC Infect Dis
Yuan R, Hu W, Chen Q, Zhuang K, Jiao F, Gui X, Xiong Y, Yang R.   +7 more
europepmc   +1 more source

Advances in Oncohematology Immunotherapy: Monoclonal Antibodies and CAR T-Cell Therapies. [PDF]

Cells
Mathias F, Fersing C, Bourgarel V, Gabert J, Peyron F.   +4 more
europepmc   +1 more source

Differential transcriptional and epigenetic signatures in CD4⁺ T cells separate enthesitis related and psoriatic juvenile idiopathic arthritis - a pilot study. [PDF]

J Transl Autoimmun
McClurg O, Hawkes J, Bates F, Carvalho AS, Pain CE, McCann LJ, Hedrich CM.   +6 more
europepmc   +1 more source

Ryanodine Receptor 1 Is Dispensable for CD4⁺ T-Cell Differentiation and Effector Function in Intestinal Inflammation Models. [PDF]

Eur J Immunol
Dostiar Tabrizi S, Nawrocki M, Bedke T, Böttcher M, Stumme F, Birus M, Möckl F, Hernandez L, Diercks BP, Gagliani N, Lodygin D, Flügel A, Guse AH, Mittrücker HW, Huber S.   +14 more
europepmc   +1 more source

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A class of costimulatory CD28-bispecific antibodies that enhance the antitumor activity of CD3-bispecific antibodies

Science Translational Medicine, 2020
CD28 bispecific antibodies are well tolerated and enhance the antitumor efficacy of CD3 bispecifics as a potential off-the-shelf antibody therapy. Double trouble for tumors Bispecific antibodies, which have one arm that binds to a cancer cell antigen and
D. Skokos, Janelle C. Waite, Lauric Haber, Alison Crawford, Aynur Hermann, E. Ullman, Rabih Slim, Stephen Godin, D. Ajithdoss, Xuan Ye, Bei Wang, Qi Wu, Ilyssa Ramos, Arpita Pawashe, Lauren Canova, Kristin Vazzana, Priyanka Ram, E. Herlihy, Hassan Ahmed, E. Oswald, Jacquelynn Golubov, P. Poon, Lauren S. Havel, D. Chiu, Miguel Lazo, Kathleen Provoncha, Kevin Yu, Julie Kim, Jacqueline J Warsaw, Nicole Stokes Oristian, C. Siao, Drew Dudgeon, Tammy Huang, Terra Potocky, Joel Martin, D. MacDonald, A. Oyejide, A. Rafique, W. Poueymirou, J. Kirshner, Eric J. Smith, W. Olson, J. Lin, G. Thurston, M. Sleeman, A. Murphy, G. Yancopouloš   +46 more
semanticscholar   +1 more source