Results 21 to 30 of about 389,148 (301)
The T cell receptor/CD3 complex is composed of at least two autonomous transduction modules [PDF]
, 1992 Recent studies have demonstrated that the CD3-ζ subunit of the T cell antigen receptor (TCR) complex is involved in signal transduction. However, the function of the remaining invariant subunits, CD3-γ, -δ, and , is still poorly understood.
Wegener, Anne-Marie K. +19 more
core +1 more source
An Anti-CD3 Antibody, Teplizumab, in Relatives at Risk for Type 1 Diabetes
New England Journal of Medicine, 2019 BACKGROUND Type 1 diabetes is a chronic autoimmune disease that leads to destruction of insulin-producing beta cells and dependence on exogenous insulin for survival.
Kevan C. Herold +20 more
semanticscholar +1 more source
Clinical Cancer Research, 2020 Purpose: Small cell lung cancer (SCLC) is the most lethal and aggressive subtype of lung carcinoma characterized by highly chemotherapy-resistant recurrence in the majority of patients.
S. Hipp +7 more
semanticscholar +1 more source
Virology Journal, 2007 Background HTLV-I infected CD4+ T-cells lines usually progress towards a CD3- or CD3low phenotype. In this paper, we studied expression, kinetics, chromatin remodeling of the CD3 gene at different time-points post HTLV-I infection.
Martiat Philippe +8 more
doaj +1 more source
Expansion of mixed immune cells using CD3/CD161 co-stimulation for the treatment of cancer
Scientific Reports, 2023 Adoptive cell transfer (ACT) is a type of personalized immunotherapy in which expanded immune cells are administered to patients with cancer. However, single-cell populations, such as killer T cells, dendritic cells, natural killer (NK) cells, and NKT ...
Ryo Tsumura +3 more
doaj +1 more source
Nature Communications, 2018 Tumor cells can fuel their metabolism with lactate. Here the authors show that inhibition of mitochondrial pyruvate carrier (MPC) blocks extracellular lactate uptake by promoting intracellular pyruvate accumulation and inhibits oxidative metabolism ...
Cyril Corbet +12 more
doaj +1 more source
Diagnostic significance of the determination of peripheral blood lymphocytes for predicting the onset of pregnancy in patients with repeated implant failures in groups with different protocols of the assisted reproductive technology program [PDF]
Гинекология, 2017 Purpose of the study. Study of the diagnostic significance of the determination of peripheral blood lymphocytes with phenotypes significantly different from the control values for predicting the onset of pregnancy in groups with different protocols of ...
T S Amyan +4 more
doaj
CD3 bispecific antibody–induced cytokine release is dispensable for cytotoxic T cell activity
Science Translational Medicine, 2019 Cytokine release induced by anti-HER2/CD3 is mediated by TNF-α and can be suppressed by blocking TNF-α, IL-6, or IL-1 without affecting efficacy. Taming the cytokine beast Bispecific antibodies, which are engineered to engage a cancer cell antigen and ...
Ji Li +11 more
semanticscholar +1 more source
Activated human T cells secrete exosomes that participate in IL-2 mediated immune response signaling. [PDF]
PLoS ONE, 2012 It has previously been shown that nano-meter sized vesicles (30-100 nm), exosomes, secreted by antigen presenting cells can induce T cell responses thus showing the potential of exosomes to be used as immunological tools.
Jessica Wahlgren +4 more
doaj +1 more source
Cancer Cell, 2017 Summary The anti-FcRH5/CD3 T cell-dependent bispecific antibody (TDB) targets the B cell lineage marker FcRH5 expressed in multiple myeloma (MM) tumor cells.
Ji Li +23 more
semanticscholar +1 more source