Results 41 to 50 of about 389,148 (301)

T cell development and T cell responses in mice with mutations affecting tyrosines 292 or 315 of the ZAP-70 protein tyrosine kinase [PDF]

, 2001
After stimulation of the T cell receptor (TCR), the tyrosine residues 292 and 315 in interdomain B of the protein tyrosine kinase ZAP-70 become phosphorylated and plausibly function as docking sites for Cbl and Vav1, respectively. The two latter proteins
Magnan, A, Anne Gillet, Arrieumerlou, C, Antoine Magnan, Boyer, C, Malissen, Bernard, Vincenzo Di Bartolo, Mireille Richelme, Marie Malissen, Lin, YL, Gillet, A., Roure, A, Mura, A. M., Boyer, C., Malissen, B, Arrieumerlou, C., Malissen, M., Malissen, M, Roure, A., Richelme, M, Acuto, O, Lin, Y. L., Bernard Malissen, Claude Boyer, Malissen, B., Di Bartolo, V, Cécile Arrieumerlou, Yea-Lih Lin, Agnès Roure, Oreste Acuto, Mura, AM, Acuto, O., Richelme, M., Acuto, Oreste, Di Bartolo, V., Anne-Marie Mura, Gillet, A, Boyer, Claudine, Magnan, A.   +38 more
core   +1 more source

The impact of chronic stress associated with active armed conflict in Ukraine on the state of immunity in patients with autoimmune thyroiditis

Mìžnarodnij Endokrinologìčnij Žurnal
Background. In the context of prolonged war-related stress in Ukraine, the prevalence of psychoemotional disorders has markedly increased, significantly influencing the course of autoimmune diseases.
Yu.I. Karachentsev, I.V. Gopkalova, V.N. Dubovik, O.A. Goncharova, E.M. Ashurov, L.V. Gerasimenko, V.А. Makedonska   +6 more
doaj   +1 more source

HCV RNA-containing sera inhibit antigen-specific and anti-CD3-mediated T cell receptor signaling.

, 2017
Healthy donor PBMCs were incubated in serum obtained before or following curative HCV therapy for 24 hrs, stimulated with a pool of antigenic peptides from CMV, EBV, and influenza virus (CEF; A) or anti-CD3 (B), and IL-2 measured 16 hrs later.
Nirjal Bhattarai (802012), Jinhua Xiang (93812), James H. McLinden (93813), Thomas M. Kaufman (802013), Warren N. Schmidt (3617348), M. Meleah Mathahs (3617354), Jack T. Stapleton (93816)   +6 more
core   +1 more source

Intratumoral CD3 and CD8 T-Cell Densities Associated with Relapse Free Survival in HCC

Cancer immunology research, 2016
Tumor immune infiltration is a prognostic marker for relapse in patients with colorectal cancer. The Immunoscore methodology was extended to patients with hepatocellular carcinoma.
A. Gabrielson, Yunan Wu, Hong-Kun Wang, Ji-Ji Jiang, B. Kallakury, Z. Gatalica, S. Reddy, D. Kleiner, T. Fishbein, L. Johnson, E. Island, R. Satoskar, F. Banovac, R. Jha, Jaydeep Kachhela, Perry Feng, Tiger Zhang, Anteneh A. Tesfaye, P. Prins, C. Loffredo, J. Marshall, L. Weiner, M. Atkins, A. He   +23 more
semanticscholar   +1 more source

Nonclinical Pharmacokinetics and Pharmacodynamics Characterization of Anti-CD79b/CD3 T Cell-Dependent Bispecific Antibody Using a Surrogate Molecule: A Potential Therapeutic Agent for B Cell Malignancies

Pharmaceutics, 2022
The T cell-dependent bispecific (TDB) antibody, anti-CD79b/CD3, targets CD79b and CD3 cell-surface receptors expressed on B cells and T cells, respectively.
Rajbharan Yadav, Siddharth Sukumaran, Tanja S. Zabka, Jinze Li, Amy Oldendorp, Gary Morrow, Arthur Reyes, Melissa Cheu, Jessica Li, Jeffrey J. Wallin, Siao Tsai, Laura Sun, Peiyin Wang, Diego Ellerman, Christoph Spiess, Andy Polson, Eric G. Stefanich, Amrita V. Kamath, Meric A. Ovacik   +18 more
doaj   +1 more source

Toward Gene Therapy for Human CD3 Deficiencies

, 2003
The CD3 subunits of the T cell receptor-CD3 complex (TCR-CD3) help to regulate surface TCR-CD3 expression, and participate in signal transduction leading to intrathymic selection and peripheral antigen recognition by T lymphocytes.
A. Pacheco-Castro, Pacheco Castro, A., Martin-Fernandez, JM, Regueiro González-Barros, José Ramón, J.R. Regueiro, Millán, R., R. Millán, Sanal, O., Pacheco-Castro, A, Sanal, O, L. Allende, Regueiro, JR, Allende, L, J.M. Martín-Fernández, Millan, R, Allende Martínez, Luis Miguel, Martín Fernández, J.M., O. Sanal   +17 more
core   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Rigid crosslinking of the CD3 complex leads to superior T cell stimulation

Frontiers in Immunology
Functionally bivalent non-covalent Fab dimers (Bi-Fabs) specific for the TCR/CD3 complex promote CD3 signaling on T cells. While comparing functional responses to stimulation with Bi-Fab, F(ab’)2 or mAb specific for the same CD3 epitope, we observed ...
Alfreda D. Nelson, Liangyu Wang, Kimberly G. Laffey, Laura R. E. Becher, Christopher A. Parks, Michele M. Hoffmann, Belinda K. Galeano, Ashutosh Mangalam, Emma Teixeiro, Emma Teixeiro, Tommi A. White, Adam G. Schrum, Adam G. Schrum, Adam G. Schrum, John F. Cannon, Diana Gil, Diana Gil, Diana Gil   +17 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Immuno-PET imaging of tumor-infiltrating lymphocytes using zirconium-89 radiolabeled anti-CD3 antibody in immune-competent mice bearing syngeneic tumors

PLoS ONE, 2018
The ability to non-invasively monitor tumor-infiltrating T cells in vivo could provide a powerful tool to visualize and quantify tumor immune infiltrates.
Denis R. Beckford Vera, Christof C. Smith, L. Bixby, Dylan M. Glatt, Stuart S. Dunn, Ryoichi Saito, William Y. Kim, J. Serody, B. Vincent, Matthew C. Parrott   +9 more
semanticscholar   +1 more source