Results 131 to 140 of about 304,036 (298)

Failure to synthesize the human T-cell CD3-zeta chain and its consequence for the T-cell receptor-CD3 complex expression

, 1989
Udgivelsesdato: 1989-AugThe T-cell antigen receptor is composed of two variable chains (alpha and beta, termed TcR) which confer ligand specificity, and four constant chains (gamma, delta, epsilon, and zeta, collectively termed CD3) whose functions are ...
Plesner, T, Rubin, B, Geisler, C, Kuhlmann, J   +3 more
core   +1 more source

Evaluation of the clinical significance of lymphocyte subsets and myeloid suppressor cells in patients with renal carcinoma

Discover Oncology
Purpose The purpose of this study was to analyze the expression patterns of immune cells in renal cancer patients, including myeloid-derived suppressor cells (MDSCs), regulatory T cells (Tregs), CD3 + /CD4 + T cells, CD3 + / CD8 + T cells, and CD3- CD16 +
Yan Li, Zhiping Wu, Chen Ni, Yueda Li, Ping Wang   +4 more
doaj   +1 more source

CD3

Citation: 'CD3' in the IUPAC Compendium of Chemical Terminology, 5th ed.; International Union of Pure and Applied Chemistry; 2025. Online version 5.0.0, 2025. 10.1351/goldbook.12972 • License: The IUPAC Gold Book is licensed under Creative Commons Attribution-ShareAlike CC BY-SA 4.0 International for individual terms.
openaire   +1 more source

Defect‐Engineered BiO2‐X Nanosheets Mediate Sono‐Thermomechanical ECM Remodeling for Hepatocellular Carcinoma Immunotherapy

Advanced Science, EarlyView.
Herein, an ultrasound‐responsive BiO2‐X/siFn1 nanoplatform is developed to overcome anti‐PD‐1 resistance in hepatocellular carcinoma. Upon ultrasound irradiation, the platform downregulates fibronectin expression, while its sonothermal effect softens the dense extracellular matrix and activates antitumor immunity in the tumor microenvironment, thereby ...
Huimin Tian, Shen Zhang, Bolin Wu, Yichi Chen, Haitao Shang, Haoyan Tan, Chunyue Wang, Weichen Xu, Huixiong Xu, Haohao Yin, Wen Cheng   +10 more
wiley   +1 more source

Nutrient deprivation increases CD3 expression in RAW cells and augments the CD3-induced proinflammatory profile, associated with NFAT and IRF-1

Frontiers in Immunology
BackgroundMyeloid cells can express lymphoid markers, including components of the CD3-TCR complex. CD3+ macrophages have been identified in both infectious and non-infectious pathologies; however, their origin and signaling mechanisms remain poorly ...
Ranferi Ocaña-Guzman, Lucero A. Ramon-Luing, Jahir Mendoza-Ruiz, Guillermo López-Chávez, Alondra Hernández-Hernández, A. Yarelli Huerta-Zarco, Julio Flores-Gonzalez, Leslie Chavez-Galan   +7 more
doaj   +1 more source

Representative immunostaining of CD3⁺ TILs in lung tumors.

, 2012
(A) Representative of CD3 immunostaining of TILs in lung tumors with low TIL density (
Lee Wang (122710), Tzu-Chin Wu (147095), Wen-Pin Chien (147103), Huei Lee (122731), Chih-Yi Chen (147109), Yaw-Cheng Wang (147089), Shwn-Huey Shieh (147114), Ya-Wen Cheng (122726), Wen-Wei Sung (122706)   +8 more
core   +1 more source

A Synthetic Platform for Antibody Junctional Diversification Beyond Natural Constraints

Advanced Science, EarlyView.
ARESEC is a synthetic platform that reconstructs functional V(D)J recombination in HEK293T cells. By introducing RSS elements and co‐expressing RAG1/2 and TdT across all three antibody CDRs, it enables programmable junctional diversification and direct generation of high‐affinity variants targeting PD‐1/PD‐L1, overcoming the evolutionary constraints of
Wang Liu, Jun Yang, Yuhang Zhang, Xiaoli Xue   +3 more
wiley   +1 more source

Analysis of IFNG expression in CD3+ and CD3- cell subsets.

, 2015
PBMC from LTBI+ donors were stimulated with PPD or left unstimulated, stained with antibodies against surface markers as indicated, probed with Cy5-labeled IFNG probes, and analyzed by flow cytometry.
Riccardo Arrigucci (836859), Sanjay Tyagi (8954), Alfred Lardizabal (836863), Richard Pine (836862), Maria Laura Gennaro (836864), Yuri Bushkin (33972), Karim Lakehal (836860), Pooja Vir (836858), Amy L. Davidow (836861)   +8 more
core   +1 more source

Autophagy Orchestrates Anti‐Tumor Immunity to Enhance Chemosensitivity via the FBXW2/C/EBPβ/TIMP‐2 Axis in Colorectal Cancer

Advanced Science, EarlyView.
Chemotherapy leverages tumor‐cell autophagy to reshape the colorectal cancer immune microenvironment. Autophagy degrades FBXW2 to promote C/EBPβ‐mediated TIMP‐2 transcription and MMP‐9 suppression, driving intra‐tumoral CD8+ T‐cell infiltration. Targeting MMP‐2/9 or restoring TIMP‐2 overcomes chemo‐resistance in autophagy‐deficient tumors. ABSTRACT The
Bing Cheng, Chaoying Wei, Zhitong Niu, Jinxin Chen, Guojie Long, Yingzhen Weng, Qiufeng Liu, Yue Jiang, Panpan Wang, Ronghua Zhang, Qiang Yu, Xiaojian Wu, Wenyu Wang   +12 more
wiley   +1 more source

Application of peripheral blood cytokine and immunoglobulin detection in ACTH therapy for the treatment of infantile spasms

Frontiers in Pediatrics
ObjectiveThis research aims to investigate the levels of lymphocytes, immunoglobulins, and cytokines in children with infantile spasms (IS) before and after adrenocorticotropic hormone (ACTH) therapy and to explore the application of these markers in ...
Xiaocui Wang, Qin Huang, Lulu Wu, Yang Yang, Xiaofei Ye, Bin Yang   +5 more
doaj   +1 more source