Results 111 to 120 of about 280,132 (264)

CD3-negative lymphokine-activated cytotoxic cells express the CD3 epsilon gene.

, 1988
The expression of genes encoding different polypeptide chains of the TCR-CD3 complex was analyzed in a panel of cloned MHC-unrestricted cytotoxic cells. The clones were derived from CD3+ and CD3- human PBL.
Prigione I, MORETTA, ALESSANDRO, Biassoni R, Long EO, Ferrini S   +4 more
core  

Tumor-Infiltrating CD3- NK Cells Are More Effective than CD3+ T Cells in Killing Autologous Melanoma Cells

, 1991
We have studied the phenotype and functional activity of tumor-infiltrating lymphocytes (TIL) derived from eight human melanomas cultured for up to 60 d in the presence of recombinant IL-2.
Prade, Michael, Azogui, Orly, Margulis, Alvaro, Guillard, Maryvonne, Caillou, Bernard, Avril, Marie-Françoise   +5 more
core   +1 more source

Enhancing CAR‐T Cell Efficacy in Solid Tumors by Inhibiting CCL5/VEGF‐Mediated Angiogenesis

Advanced Science, EarlyView.
This study reveals that CAR‐T cells in solid tumors produce CCL5, which paradoxically induces VEGF and angiogenesis to promote tumor growth. Blocking CCL5/VEGF signaling—through gene knockout, or the CCR5 inhibitor maraviroc—significantly enhances the antitumor efficacy of CAR‑T therapy (the diagram was created in Biorender).
Shishuo Sun, Qihong Li, Bixi Wang, Gang Wang, Ying Xue, Yibing Liang, Chenhe Hu, Zhenyu Wang, Xiaoge Gao, Haiheng Xu, Jun Song, Hailong Li, Liantao Li, Xiaoxiao Liu, Patrick Ming‐Kuen Tang, Qing Zhang   +15 more
wiley   +1 more source

Functional profile of CD3⁺CD161⁺ and CD3⁺CD161^- alveolar lymphocytes.

, 2015
(A) Representative plots of flow cytometry analysis performed by selecting CD3+CD161+ or CD3+CD161- cells from the CD161 vs CD3 double plot or single histogram plot according to appropriate isotype control and evaluating the percentage of cytokine ...
Miguel Angel Salazar-Lezama (729170), Karen Bobadilla (729171), Esmeralda Juárez (729169), Yolanda Gonzalez (729167), María Teresa Herrera (729168), Martha Torres (729172)   +5 more
core   +1 more source

Targeting METTL3 Attenuates Thyroid Inflammatory Injury by Restoring Th17/Treg Balance through a YTHDC2‐m6A‐Dependent KDR/VEGFA Loop

Advanced Science, EarlyView.
METTL3‐mediated m6A modification stabilizes KDR/Kdr mRNA through YTHDC2, amplifying the VEGFA‐KDR feedback loop and disturbing Th17/Treg balance. This pathway promotes persistent inflammation and tissue damage in patients with AIT, and inhibiting the METTL3‐KDR axis effectively disrupts this circuit, alleviating thyroid tissue injury and disease ...
Qingyi Hu, Huan Liu, Anwen Ren, Zimei Tang, Jie Tan, Wen Yang, Jie Ming, Tao Huang   +7 more
wiley   +1 more source

Light‐Activatable Nitric Oxide Release via Intramolecular Electron Transfer for Tumor Pyroptosis Induction

Advanced Science, EarlyView.
This work proposes a novel strategy to fabricate unimolecular pyroptosis photoinitiators activated by deep‐red light at low light doses. It relies on a photosensitization mechanism to trigger nitric oxide (NO) release from benzisothiadiazole‐based N‐nitrosanilines without modification of nitro moieties, thereby boosting pyroptosis‐mediated ...
Chuangxin Zhang, Ruipeng Li, Yunxia Wang, Feng Liu, Liheng Feng   +4 more
wiley   +1 more source

Internalization and intracellular fate of TCR-CD3 complexes.

, 2000
The number of surface TCR-CD3 complexes is maintained by an equilibrium between the synthesis and secretion of new polypeptides, their internalization, recycling, and degradation.
Alarcón, B., Alcover, A.
core   +1 more source

TME/NIR Dual‐Responsive Zinc‐Based Targeted Nanoagonist for Multimodal Amplification of STING‐Mediated Cancer Immunotherapy

Advanced Science, EarlyView.
A multifunctional nanoagonist (cDZ@IP) enables nano‐metabolite–driven multimodal activation of the STING pathway and enhanced immune recognition, achieving potent antitumor immunity and suppressing tumor growth and metastasis. This strategy highlights the rational design of therapeutic metabolites and establishes a new paradigm bridging nanomedicine ...
Kepeng Hu, Jiawei Wang, Wei Zhang, Zhixuan Wu, Jing Chen, Yujing He, Xiyue Duan, Yaoting He, Xin Xin, Haoyi Xiang, Yijing Wang, Chengwei Wu, Yang Yi, Qing Meng, Yuqian Qiao, Kui Cheng, Xiaojun Long, Zhangfa Song   +17 more
wiley   +1 more source

Radiotherapy Enhances the Oncolytic Efficacy of the Novel Oncolytic Herpesvirus VG161 and Amplifies Its Antitumor Immunity in Breast Cancer

Advanced Science, EarlyView.
RT promotes VG161 replication in BC and its immunostimulatory transgenes expression, which is mediated by the upregulation of GADD34 and HVEM caused by RT. The combination therapy with VG161 and RT increases the abundances of tumor‐infiltrating lymphocytes and elicits potent systemic antitumor immunity, thereby effectively inhibiting local tumors and ...
Lijuan Lyu, Ming Yi, Ji Chen, Zeda Zhao, Ruocen Liao, Yingnan Wang, Shengtao Hu, Jun Ding, Ronghua Zhao, William Jia, Yinan Shen, Yongchang Wei, Kongming Wu, Zhijun Dai   +13 more
wiley   +1 more source

Intra-tumoral lymphocyte scoring in colorectal cancer: improving prognostic utility and correlation with underlying cancer biology

Frontiers in Gastroenterology
BackgroundIntra-tumoral lymphocytes hold prognostic and predictive significance in colorectal cancer (CRC). The internationally validated Immunoscore™ predicts CRC survival risk by averaging percentile scores of tumor-associated CD3+ and CD8+ cell ...
Patrick L. Wagner, Jianwu Xie, Devin C. Flaherty, Hyun Park, Chelsea Knotts, Justine Debelius, Curtis Tilves, Neda Dadgar, Kunhong Xiao, Ali H. Zaidi, Louis Gil Acevedo, William LaFramboise, Ni Zhao, Cynthia Sears, Noel Mueller   +14 more
doaj   +1 more source