Results 91 to 100 of about 304,036 (298)

Combating Inflammation and Promoting Anabolism in Osteoarthritic Cartilage Defect With an MMP13‐Sensing Dual‐Drug Scaffold

Advanced Science, EarlyView.
ABSTRACT Osteoarthritis (OA) is a widespread degenerative joint condition marked by progressive cartilage breakdown, and a chronic inflammatory microenvironment, where conventional therapies largely fail to halt disease progression. To address this unmet need, an intra‐articularly implantable, disease‐responsive scaffold was developed for combinatorial
Zhen Zhang, Bangheng Liu, Yulei Mu, Huiqun Zhou, Liang Ma, Chenjie Xu, Dong‐An Wang   +6 more
wiley   +1 more source

Zmiany ilościowe populacji limfocytów CD3+ i CD45RA+ we krwi szczurów poddanych działaniu wolnozmiennego pola elektromagnetycznego [PDF]

, 2007
It was reported that an extremely low frequency (ELF) electromagnetic field causes biological effects in vitro and in vivo. The major functions of the immune system are to develop the concept of "self" and eliminate what is "non-self". In our preliminary
Salwiczek, Anna, Ślusarczyk, Konstanty, Arendt, Jerzy, Drzazga, Zofia, Mazur, Bogdan, Królak-Olejnik, Barbara, Król, Wojciech, Beck, Brygida, Cholewka, Armand   +8 more
core  

The representative flow cytometric dot-plots showing intracellular expressions of interleukin (IL)-27 in CD3⁺CD4⁺ T cells, CD3⁺CD8⁺ T cells, CD3⁻CD56⁺ NK cells, CD3⁺CD56⁺ NKT cells, CD3⁻CD19⁺ B cells, CD14⁺ monocytes, CD68⁺ macrophages, and calretinin-positive mesothelial cells in tuberculous pleural effusion (TPE) and malignant pleural effusion (MPE).

, 2013
The representative flow cytometric dot-plots showing intracellular expressions of interleukin (IL)-27 in CD3+CD4+ T cells, CD3+CD8+ T cells, CD3−CD56+ NK cells, CD3+CD56+ NKT cells, CD3−CD19+ B cells, CD14+ monocytes, CD68+ macrophages, and calretinin ...
Xian-Zhi Xiong (316731), Wan-Li Ma (316730), Rong-Hui Du (316732), Wei-Bing Yang (169079), Chun-Mi Niu (316729), Qiong Zhou (169101), Qiu-Li Liang (316727), Zhi-Jian Ye (169089), Jian-Chu Zhang (316734), Huan-Zhong Shi (169095)   +9 more
core   +1 more source

MicroRNA expression profiles in human CD3+ T cells following stimulation with anti-human CD3 antibodies [PDF]

, 2017
Background: Anti-CD3 therapy can induce immunosuppression by several non mutually exclusive mechanisms that have been proposed to explain the therapeutic effect the administration anti-CD3 mAb, but its immunoregulatory mechanism is still not completely ...
Sousa, Isabel Garcia, Simi, Kelly Cristina Rodrigues, Kelly Cristina Rodrigues Simi, Marcelo Macedo Brigido, Maranhão, Andréa Queiroz, Andrade, Rosângela Vieira, Manuela Maragno do Almo, Rosângela Vieira Andrade, Almo, Manuela Maragno do, Brígido, Marcelo de Macedo, Maryani Andressa Gomes Bezerra, Bezerra, Maryani Andressa Gomes, Isabel Garcia Sousa, Andréa Queiroz Maranhão   +13 more
core   +1 more source

Co‐Delivery of Sustained Release Chondroitinase ABC‐37 With Human iPSC‐Derived Neural Progenitors Promotes Transplant Survival and Functional Recovery in a Rodent Model of Stroke

Advanced Science, EarlyView.
A regenerative strategy for stroke combines human stem cell–derived neural progenitor cells with sustained release of a matrix‐modifying, thermostable chondroitinase ABC‐37 enzyme. In a rat model of stroke, co‐delivery enhanced transplanted cell survival and neuronal differentiation, degraded inhibitory extracellular matrix components, and improved ...
Nitzan Letko Khait, David Xinzheyang Li, Keyi Guo, Hong Cui, Quinton Sirianni, Dhana Abdo, Cindi M. Morshead, Molly S. Shoichet   +7 more
wiley   +1 more source

Dichotomy of two CD8+ lymphocyte subsets in HIV infection. Depletion of CD8+ CD3- and expansion of CD8+ CD3+ subsets: consequence on the CD4/CD8 ratio

, 1991
SUMMARY In order to highlight the underlying mechanism(s) of the CD8 lymphocyte expansion in the HIV infection, two distinct CD8 subsets were analysed: T CD8bright+ CD3+ with MHC-restricted activity, and non-T CD8dim+ CD3-, which performs ...
I MANSOUR, C DOINEL, P ROUGER
core   +1 more source

Robust Photocatalytic Hydrogen Evolution Over a Conjugated Metal‐Organic Framework Heterojunction

Advanced Science, EarlyView.
We report a conjugated coordination polymer, Cd‐TMT (TMT = 1,3,5‐trimercaptotriazine), featuring an intrinsic molecular‐level charge transport network. The conjugated TMT ligands facilitate strong intra‐ligand charge transfer, while their ordered π‐π stacking along the [111] direction establishes a continuous pathway for directional electron migration,
Chunzhe Wang, Yufei Shan, Ruobing Chu, Lingzhi Yang, Zhanning Liu, Xiaoli Zhang, Jian Tian   +6 more
wiley   +1 more source

Repurposing a Small Molecule Plant Hormone as a Tunable ON‐Switch for CAR‐T Cell Immunotherapy

Advanced Science, EarlyView.
By engineering a receptor system integrating the plant auxin receptor AFB1 with its co‐receptor IAA7, we enable ligand‐dependent interactions triggered by the plant hormone auxins. This design allows rapid, reversible, and dose‐dependent T cell activation, resulting in potent cytotoxicity against B‐cell lymphoma in vitro and in vivo.
Hongxiang Zeng, Lei Zheng, Rongkun Tao, Sirui Zheng, Yanke Zhong, Yongxia Niu, Peng Zhang, Xiang Ma, Chen Yang, Min Zhang, Fuyu Duan, Jing Yang, Xuan Wei, Xiang Zhou, Zhenbiao Yang, Zhaoxi Sun, Qizhou Lian   +16 more
wiley   +1 more source

Rigid crosslinking of the CD3 complex leads to superior T cell stimulation

Frontiers in Immunology
Functionally bivalent non-covalent Fab dimers (Bi-Fabs) specific for the TCR/CD3 complex promote CD3 signaling on T cells. While comparing functional responses to stimulation with Bi-Fab, F(ab’)2 or mAb specific for the same CD3 epitope, we observed ...
Alfreda D. Nelson, Liangyu Wang, Kimberly G. Laffey, Laura R. E. Becher, Christopher A. Parks, Michele M. Hoffmann, Belinda K. Galeano, Ashutosh Mangalam, Emma Teixeiro, Emma Teixeiro, Tommi A. White, Adam G. Schrum, Adam G. Schrum, Adam G. Schrum, John F. Cannon, Diana Gil, Diana Gil, Diana Gil   +17 more
doaj   +1 more source

Total CD3+, Total CD56+ and CD3+CD56− T cell populations in patients maintaining or withdrawing therapy.

, 2013
Graphs illustrate total CD3+, Total CD56+ and CD3+CD56− T cell populations (expressed as a percentage of the lymphogate) in patients maintaining or withdrawing therapy at baseline (▴) and three months ...
Elizabeth J. Ryan (339092), Ursula Fearon (8519), Oliver FitzGerald (26005), Douglas J. Veale (339506), Barry Bresnihan (26006), Ceara E. Walsh (339504), Cliona O’Farrelly (339505), Lucy Golden-Mason (242863)   +7 more
core   +1 more source