Results 1 to 10 of about 98,309 (302)

Surface levels of CD20 determine anti-CD20 antibodies mediated cell death in vitro. [PDF]

PLoS ONE, 2014
The sensitivity of human Burkitt's lymphoma cells to rituximab (Rtx) and tositumomab (Tst) was assessed on cells expressing different levels of CD20 on surface.
Vijay Singh, Damodar Gupta, Rajesh Arora, Rajendra Prashad Tripathi, Alexandru Almasan, Roger M Macklis   +5 more
doaj   +5 more sources

HDAC6 inhibition upregulates CD20 levels and increases the efficacy of anti-CD20 monoclonal antibodies [PDF]

Blood, 2017
Key Points HDAC6 inhibition represents a novel strategy to improve the efficacy of anti-CD20 mAbs. HDAC6 inhibition increases CD20 levels by enhancing CD20 protein synthesis without affecting the gene expression.
Bobrowicz, Malgorzata, Dwojak, Michal, Pyrzynska, Beata, Stachura, Joanna, Muchowicz, Angelika, Berthel, Elise, Dalla-Venezia, Nicole, Kozikowski, Mieszko, Siernicka, Marta, Miazek, Nina, Zapala, Piotr, Domagala, Antoni, Bojarczuk, Kamil, Malenda, Agata, Barankiewicz, Joanna, Graczyk-Jarzynka, Agnieszka, Zagozdzon, Agnieszka, Gabrysiak, Magdalena, Diaz, Jean-Jacques, Karp, Marta, Lech-Maranda, Ewa, Firczuk, Malgorzata, Giannopoulos, Krzysztof, Efremov, Dimitar G, Laurenti, Luca, Baatout, Dunja, Frenzel, Lukas, Malinowska, Agata, Slabicki, Mikolaj, Zenz, Thorsten, Zerrouqi, Abdessamad, Golab, Jakub, Winiarska, Magdalena   +32 more
core   +5 more sources

The Biological Activity of Human CD20 Monoclonal Antibodies Is Linked to Unique Epitopes on CD20 [PDF]

The Journal of Immunology, 2006
Abstract We have previously defined a panel of fully human CD20 mAb. Most of these were unexpectedly efficient in their ability to recruit C1q to the surface of CD20-positive cells and mediate tumor lysis via activation of the classical pathway of complement.
Teeling, Jessica L., Mackus, Wendy J.M., Wiegman, Luus J.J.M., van den Brakel, Jeroen H.N., Beers, Stephen A., French, Ruth R., van Meerten, Tom, Ebeling, Saskia, Vink, Tom, Slootstra, Jerry W., Parren, Paul W.H.I., Glennie, Martin J., van den Winkel, Jan G.J.   +12 more
core   +5 more sources

Dual-trigger model of CD20 escape: NONO regulation and cryptic splicing induced by transcript overload in pediatric B-ALL [PDF]

Frontiers in Immunology
IntroductionThe B-cell-specific marker CD20 is expressed in various B-cell malignancies, including B-cell acute lymphoblastic leukemia (B-ALL) and serves as a key target for immunotherapies.
Moein Kermani, Sebastian Maxeiner, Francesca Alt, Nicole Ziegler, Julian König, Claudia Paret, Claudia Paret, Claudia Paret, Jörg Faber, Jörg Faber, Jörg Faber   +10 more
doaj   +2 more sources

Anti-CD20 monoclonal antibodies: reviewing a revolution

Human Vaccines and Immunotherapeutics, 2018
Since the inception of rituximab in the 1990s, anti-CD20 monoclonal antibodies have revolutionised the treatment of B cell hematological malignancies and have become a cornerstone of modern gold-standard practice.
Stephen Opat
exaly   +2 more sources

CD20 tails interact with the 14-3-3/GEF-H1 complex and microtubule network upon PKCδ phosphorylation [PDF]

The EMBO Journal
CD20 is a four-helix transmembrane protein specifically expressed in B-cells that serves as a prominent target of therapeutic anti-CD20 antibodies. It is localized in a membrane nanocluster harboring the B-cell antigen receptor of IgD class (IgD-BCR ...
Kathrin Kläsener, Cindy Eunhee Lee, Julian Bender, Angela Naumann, Lena Reimann, Geoffroy Andrieux, Claudio Mussolino, Nadja Herrmann, Roland Nitschke, Reinhard E Voll, Bettina Warscheid, Klaus Warnatz, Michael Reth   +12 more
doaj   +2 more sources

The origin of human CD20+ T cells: a stolen identity? [PDF]

Frontiers in Immunology
Human T cells expressing CD20 play an important role in the defense against virus and cancer and are central in the pathogenesis of both malignancies and various autoimmune disorders.
Marina Rode von Essen, Lisbeth Egelykke Stolpe, Helle Bach Søndergaard, Finn Sellebjerg   +3 more
doaj   +2 more sources

CD4 and CD20 as important immune markers in patients with pulmonary tuberculosis [PDF]

E3S Web of Conferences, 2023
Tuberculosis (TB) is a serious lung infection caused by the bacterium Mycobacterium tuberculosis (M. tuberculosis) is highly contagious, and can be spread through the air from an infected person to others.
Kamoona Firas Mohammad Hussein, Aljanaby Ahmed Abduljabbar Jaloob   +1 more
doaj   +1 more source

Spontaneous Tumor Lysis Syndrome in a Patient with Mantle Zone Cell Lymphoma [PDF]

Liaquat National Journal of Cancer Care, 2022
We describe the case of a patient diagnosed to have Mantle cell lymphoma (MCL), who underwent spontaneous tumor lysis syndrome, with overwhelming metabolic acidosis and acute kidney injury, was managed conservatively without the need for hemodialysis ...
Ikram A. Burney, Syed Azhar Rizvi
doaj   +1 more source

Non-Hodgkin lymphoma of cauda equina: A diagnostic conundrum: Case report

Advanced Biomedical Research, 2023
Primary central nervous system lymphoma (PCNSL) is uncommon with scarce cases having involvement of the spinal cord. Cauda equina is unique in its location and shows very rare involvement by diseases pathologies.
Pranati Misra, Ranjita Panigrahi, Prita Pradhan, Debashis Pothal, Urmila Senapati, Narendra K Das   +5 more
doaj   +1 more source