Results 11 to 20 of about 106,748 (296)

The Biological Activity of Human CD20 Monoclonal Antibodies Is Linked to Unique Epitopes on CD20 [PDF]

The Journal of Immunology, 2006
Abstract We have previously defined a panel of fully human CD20 mAb. Most of these were unexpectedly efficient in their ability to recruit C1q to the surface of CD20-positive cells and mediate tumor lysis via activation of the classical pathway of complement.
Teeling, Jessica L., Mackus, Wendy J.M., Wiegman, Luus J.J.M., van den Brakel, Jeroen H.N., Beers, Stephen A., French, Ruth R., van Meerten, Tom, Ebeling, Saskia, Vink, Tom, Slootstra, Jerry W., Parren, Paul W.H.I., Glennie, Martin J., van den Winkel, Jan G.J.   +12 more
core   +5 more sources

Ocrelizumab Depletes CD20+ T Cells in Multiple Sclerosis Patients

Cells, 2018
Ocrelizumab, a humanized monoclonal anti-CD20 antibody, has shown pronounced effects in reduction of disease activity in multiple sclerosis (MS) patients and has recently been approved for the treatment of patients with relapsing MS (RMS) and primary ...
Stefan Gingele, Thais Langer Jacobus, Franz Felix Konen, Martin W. Hümmert, Kurt-Wolfram Sühs, Philipp Schwenkenbecher, Jonas Ahlbrecht, Nora Möhn, Lars H. Müschen, Lena Bönig, Sascha Alvermann, Reinhold E. Schmidt, Martin Stangel, Roland Jacobs, Thomas Skripuletz   +14 more
doaj   +2 more sources

Change of CD20 Expression in Diffuse Large B-Cell Lymphoma Treated with Rituximab, an Anti-CD20 Monoclonal Antibody: A Study of the Osaka Lymphoma Study Group

Case Reports in Oncology, 2009
Change of CD20 expression was examined in cases of diffuse large B-cell lymphoma (DLBCL). CD20 expression after treatment with anti-CD20 antibody (rituximab, Rx) for DLBCL was examined in 23 cases who received serial biopsy by immunohistochemistry (IHC ...
Naoki Wada, Masaharu Kohara, Hiroyasu Ogawa, Haruo Sugiyama, Shirou Fukuhara, Yoichi Tatsumi, Akihisa Kanamaru, Masayuki Hino, Yuzuru Kanakura, Eiichi Morii, Katsuyuki Aozasa   +10 more
doaj   +2 more sources

The origin of human CD20+ T cells: a stolen identity? [PDF]

Frontiers in Immunology
Human T cells expressing CD20 play an important role in the defense against virus and cancer and are central in the pathogenesis of both malignancies and various autoimmune disorders.
Marina Rode von Essen, Lisbeth Egelykke Stolpe, Helle Bach Søndergaard, Finn Sellebjerg   +3 more
doaj   +2 more sources

Disease Course After Anti-CD20 Discontinuation in Secondary Progressive Multiple Sclerosis-A Multicenter Long-Term Longitudinal Study. [PDF]

Ann Clin Transl Neurol
ABSTRACT Objective To describe long‐term outcomes after anti‐CD20 discontinuation in selected patients with secondary progressive multiple sclerosis (SPMS) who remained without subsequent disease‐modifying therapy (DMT). Methods We retrospectively analyzed data from four centers in Austria and Switzerland.
Otto F, Kliushnikova D, Radlberger RF, Yasaroglu S, Moser T, Harrer A, Kratzer K, Hitzl W, Gradl C, Schmidauer M, Roth P, Hegen H, Wipfler P.   +12 more
europepmc   +2 more sources

Anti-CD20 Discontinuation Versus Continuation in People Aged Over 50 With Non-Active Multiple Sclerosis. [PDF]

Ann Clin Transl Neurol
ABSTRACT Objective To determine whether discontinuing anti‐CD20 therapy in people with relapsing‐onset MS aged over 50 is associated with an increased risk of relapse, inflammatory activity, confirmed disability accrual, and serious infection compared with continuing therapy.
Moukhine A, Rollot F, Casey R, Collongues N, Vukusic S, Mathey G, Dubessy AL, Ciron J, De Seze J, Ruet A, Labauge P, Kwiatkowski A, Zephir H, Papeix C, Defer G, Lebrun-Frenay C, Laplaud DA, Berger E, Thouvenot E, Pelletier J, Al Khedr A, Casez O, Bourre B, Wahab A, Magy L, Camdessanché JP, Doghri I, Moulin S, Rivière MS, Hankiewicz K, Santos AD, Pottier C, Manchon E, Aboab J, Tchikviladze M, David T, Edan G, Le Page E, Michel L, Kerbrat A, OFSEP Investigators.   +40 more
europepmc   +2 more sources

DataSheet_1_Potent immunomodulatory and antitumor effect of anti-CD20-IL2no-alpha tri-functional immunocytokine for cancer therapy.pdf

, 2022
IntroductionThe anti-CD20 antibody rituximab (RTX) has substantially improved outcomes of patients with B-cell lymphomas, although more efficient therapies are needed for refractory or relapsing lymphomas.
Claudia Plasencia (14238803), Kalet León (2795161), Miguel Ángel González (14238785), Addys González (14238794), Beatriz María Cruz (14238779), Katya Sosa (14238797), Kathleen Castro (14238800), Nuris Ledón (4266283), Calixto Hernández (14238809), Tania Gómez (14238788), Tays Hernández (14238812), Ana Victoria Casadesús (14238776), Wilden Díaz (14238782), Briandy Fernández (14238791), Armando López (541227), Jean-Luc Teillaud (154584), Yaima Ramírez (14238806)   +16 more
core   +1 more source

Binding mechanisms of therapeutic antibodies to human CD20 [PDF]

, 2020
International audienceMonoclonal antibodies (mAbs) targeting human antigen CD20 (cluster of differentiation 20) constitute important immunotherapies for the treatment of B cell malignancies and autoimmune diseases.
Reyes, Nicolas, Planchais, Cyril, Mouquet, Hugo, Fronzes, Rémi, Kumar, Anand   +4 more
core   +1 more source

Evaluating the difference in clinical efficacy for t(11;14) multiple myeloma patients with CD20- or CD20+ [PDF]

, 2023
Objective To examine the differences in therapy response and confirm the effective regimen for multiple myeloma (MM) patients with t (11; 14)/CD20- or CD20+, for the selection of transplantation as early treatment.
ZHAO Weihong, HUANG Bintao, LIU Rui, XIANG Caixia
core   +1 more source

HDAC6 inhibition upregulates CD20 levels and increases the efficacy of anti-CD20 monoclonal antibodies

, 2017
Key Points HDAC6 inhibition represents a novel strategy to improve the efficacy of anti-CD20 mAbs. HDAC6 inhibition increases CD20 levels by enhancing CD20 protein synthesis without affecting the gene expression.
Beata Pyrzynska, Piotr Zapala, Marta Karp, Nina Miazek, Lukas Frenzel, Michal Dwojak, Angelika Muchowicz, Magdalena Winiarska, Antoni Domagala, Agnieszka Graczyk-Jarzynka, Agnieszka Zagozdzon, Thorsten Zenz, Luca Laurenti, Malgorzata Firczuk, Elise Berthel, Dimitar G. Efremov, Nicole Dalla-Venezia, Dunja Baatout, Malgorzata Bobrowicz, Agata Malinowska, Mieszko Kozikowski, Magdalena Gabrysiak, Jakub Golab, Joanna Stachura, Kamil Bojarczuk, Mikolaj Slabicki, Agata Malenda, Joanna Barankiewicz, Krzysztof Giannopoulos, Marta Siernicka, Ewa Lech-Maranda, Abdessamad Zerrouqi, Jean-Jacques Diaz   +32 more
core   +3 more sources