Results 1 to 10 of about 33,041 (261)

An oncolytic measles virus engineered to enter cells through the CD20 antigen

Molecular Therapy, 2003
We have earlier shown that attenuated measles virus (MV) has therapeutic potential as a replicating oncolytic virus in models of non-Hodgkin's lymphoma (NHL). In the current study, we investigated whether we could obtain replicating MVs capable of entering CD20(+) target cells through an interaction between a single-chain (scFv) anti-CD20 antibody and ...
Shaji Kumar, Deanna M Grote, Yukang Lin   +2 more
exaly   +3 more sources

T Cells Expressing CD19/CD20 Bispecific Chimeric Antigen Receptors Prevent Antigen Escape by Malignant B Cells [PDF]

Cancer Immunology Research, 2016
The adoptive transfer of T cells expressing anti-CD19 chimeric antigen receptors (CARs) has shown remarkable curative potential against advanced B-cell malignancies, but multiple trials have also reported patient relapses due to the emergence of CD19 ...
Michael C. Jensen, Yvonne Y. Chen, Anne Silva-Benedict, Jensen, Michael C, Meng-Yin Lin, Zah, Eugenia, Eugenia Zah, Lin, Meng-Yin, Silva-Benedict, Anne, Chen, Yvonne Y   +9 more
core   +5 more sources

Development of a monoclonal antibody for the detection of anti-canine CD20 chimeric antigen receptor expression on canine CD20 chimeric antigen receptor-transduced T cells

Journal of Veterinary Medical Science, 2021
Chimeric antigen receptor (CAR) CAR-T cell therapy targeting CD20 can be a novel adoptive cell therapy for canine patients with B-cell malignancy. After injection of the CAR-T cells in vivo, monitoring circulating CAR-T cells is essential to prove in vivo persistence of CAR-T cells. In this study, we developed a novel monoclonal antibody against canine
SAKAI, Osamu, OGINO, Shoji, TSUKUI, Toshihiro, IGASE, Masaya, MIZUNO, Takuya   +4 more
openaire   +3 more sources

Antigenic modulation limits the efficacy of anti-CD20 antibodies: implications for antibody selection [PDF]

Blood, 2010
Abstract Rituximab, a monoclonal antibody that targets CD20 on B cells, is now central to the treatment of a variety of malignant and autoimmune disorders. Despite this success, a substantial proportion of B-cell lymphomas are unresponsive or develop resistance, hence more potent anti-CD20 monoclonal antibodies (mAbs) are continuously
Beers, Stephen A., French, Ruth R., Chan, Claude H.T., Lim, Sean H., Jarrett, Timothy C., Mora Vidal, Regina, Wijayaweera, Sahan S., Dixon, Sandra V., Kim, Hyung J., Cox, Kerry L., Kerr, Jonathan P., Johnston, David A., Johnson, Peter W.M., Verbeek, Sjef, Glennie, Martin J., Cragg, Mark S.   +15 more
openaire   +4 more sources

Construction and evaluation of wild and mutant ofatumumab scFvs against the human CD20 antigen

Preparative Biochemistry & Biotechnology, 2022
Several monoclonal antibodies targeting the CD20 have been produced and Ofatumumab is a case in point. Although whole antibodies target cancer cells effectively, their applications are restricted in some ways. Single-chain fragment variable antibodies, rather than employing the entire structure of antibodies, have proven a practical approach for ...
Reza Maleki, Azam Rahimpour, Masoumeh Rajabibazl   +2 more
openaire   +2 more sources

Long-lived antibody and B Cell memory responses to the human malaria parasites, Plasmodium falciparum and Plasmodium vivax. [PDF]

, 2010
Antibodies constitute a critical component of the naturally acquired immunity that develops following frequent exposure to malaria. However, specific antibody titres have been reported to decline rapidly in the absence of reinfection, supporting the ...
Thaikla, Kanitta, Riley, Eleanor M, Julius Clemence R Hafalla, Cook Jackie, Lucy C Okell, Eleanor M Riley, Suphavilai Chaisuree, Lucy C. Okell, Witaya Liewsaree, Okell, Lucy C, Liewsaree, W, Corran Patrick H., Hafalla Julius Clemence R., Cook, Jackie, Corran, Patrick H, Kanitta Thaikla, Cook, J, Patrick H. Corran, Hafalla, Julius Clemence R, Chaisuree Suphavilai, Wipasa, J, Suphavilai, C, Okell Lucy C., Riley Eleanor M., Jackie Cook, Wipasa Jiraprapa, Julius Clemence R. Hafalla, Liewsaree, Witaya, Suphavilai, Chaisuree, Thaikla, K, Eleanor M. Riley, Patrick H Corran, Hafalla, JC, Thaikla Kanitta, Wipasa, Jiraprapa, Okell, LC, Riley, EM, Corran, PH, Liewsaree Witaya, Jiraprapa Wipasa   +39 more
core   +1 more source

FMC7 ist Teil des CD20-Antigenkomplexes [PDF]

, 2004
Das FMC7-Antigen, eine unbekannte B-Zell-Membranstruktur, dient als eines der immunphänotypischen Grundkriterien zur Diagnose der typischen B-CLL.
Jordanova, Maya
core   +1 more source

Preclinical Optimization of a CD20-specific Chimeric Antigen Receptor Vector and Culture Conditions [PDF]

Journal of Immunotherapy, 2018
Chimeric antigen receptor (CAR)-based adoptive T-cell therapy is a highly promising treatment for lymphoid malignancies, and CD20 is an ideal target antigen. We previously developed a lentiviral construct encoding a third generation CD20-targeted CAR but identified several features that required additional optimization before clinical translation.
Sang Yun, Lee, Philip, Olsen, Dong Hoon, Lee, Aimee L, Kenoyer, Lihua E, Budde, Shyril, O'Steen, Damian J, Green, Shelly, Heimfeld, Michael C, Jensen, Stanley R, Riddell, Oliver W, Press, Brian G, Till   +11 more
openaire   +2 more sources

Immuno-biosensor for Detection of CD20-Positive Cells Using Surface Plasmon Resonance [PDF]

, 2017
Purpose: Surface plasmon resonance (SPR) sensing confers a real-time assessment of molecular interactions between biomolecules and their ligands. This approach is highly sensitive and reproducible and could be employed to confirm the successful binding ...
Dariush Shanehbandi, Behzad Baradaran, Leili Aghebati-Maleki, Jafar Majidi, Tohid Kazemi, Jafar Ezzati Nazhad Dolatabadi, Farzaneh Fathi   +6 more
core   +1 more source

Functional Recombinant Extra Membrane Loop of Human CD20, an Alternative of the Full Length CD20 Antigen

Iranian biomedical journal, 1996
Iranian Biomedical Journal (IBJ); ISSN 1028 ...
Mahdi, Habibi Anbouhi, Aida, Feiz Barazandeh, Saeid, Bouzari, Mohsen, Abolhassani, Hossein, Khanahmad, Majid, Golkar, Mohammad Reza, Aghasadeghi, Mahdi, Behdani, Ali, Jahanian-Najafabadi, Mohammad Ali, Shokrgozar   +9 more
openaire   +2 more sources