Results 41 to 50 of about 4,418 (114)

Multiple Myeloma Includes Phenotypically Defined Subsets of Clonotypic CD20+ B Cells that Persist during Treatment with Rituximab

Clinical Medicine Insights: Oncology, 2008
Potential progenitor B cell compartments in multiple myeloma (MM) are clinically important. MM B cells and some circulating MM plasma cells express CD20, predicting their clearance by treatment with anti-CD20.
Linda M. Pilarski, Eva Baigorri, Michael J. Mant, Patrick M. Pilarski, Penelope Adamson, Heddy Zola, Andrew R. Belch   +6 more
doaj   +1 more source

Immune cells and tryptophan metabolism in the joint capsule tissue in rheumatoid arthritis

Acta Biomedica Scientifica
To the present day, many links in the pathogenesis of rheumatoid arthritis remain unclear, which leads to unsatisfactory results in its therapy.The aim.
E. A. Stepanov
doaj   +1 more source

The origin of human CD20+ T cells: a stolen identity?

Frontiers in Immunology
Human T cells expressing CD20 play an important role in the defense against virus and cancer and are central in the pathogenesis of both malignancies and various autoimmune disorders.
Marina Rode von Essen, Lisbeth Egelykke Stolpe, Helle Bach Søndergaard, Finn Sellebjerg   +3 more
doaj   +1 more source

Dual-trigger model of CD20 escape: NONO regulation and cryptic splicing induced by transcript overload in pediatric B-ALL

Frontiers in Immunology
IntroductionThe B-cell-specific marker CD20 is expressed in various B-cell malignancies, including B-cell acute lymphoblastic leukemia (B-ALL) and serves as a key target for immunotherapies.
Moein Kermani, Sebastian Maxeiner, Francesca Alt, Nicole Ziegler, Julian König, Claudia Paret, Claudia Paret, Claudia Paret, Jörg Faber, Jörg Faber, Jörg Faber   +10 more
doaj   +1 more source

Retroviral transfer of human CD20 as a suicide gene for adoptive T-cell therapy

Haematologica, 2009
The aim of adoptive T-cell therapy of cancer is to selectively confer immunity against tumor cells. Autoimmune side effects, however, remain a risk, emphasizing the relevance of a suicide mechanism allowing in vivo elimination of infused T cells.
Marieke Griffioen, Esther H.M. van Egmond, Michel G.D. Kester, Roel Willemze, J.H. Frederik Falkenburg, Mirjam H.M. Heemskerk   +5 more
doaj   +1 more source

The in vivo mechanism of action of CD20 monoclonal antibodies depends on local tumor burden

Haematologica, 2011
Background CD20 monoclonal antibodies are widely used in clinical practice. Antibody-dependent cellular cytotoxicity, complement-dependent cytotoxicity and direct cell death have been suggested to be important effector functions for CD20 antibodies ...
Peter Boross, J.H. Marco Jansen, Simone de Haij, Frank J. Beurskens, Cees E. van der Poel, Lisette Bevaart, Maaike Nederend, Josée Golay, Jan G.J. van de Winkel, Paul W.H.I. Parren, Jeanette H.W. Leusen   +10 more
doaj   +1 more source

Cd20-negative diffuse large b-cell lymphoma subtype: a look at texas cancer registry

Hematology Reports, 2020
Introduction CD20-negative diffuse large B-cell lymphoma (DLBCL) histologic subtypes are rare and aggressive lymphomas. As these lymphomas are rare, most epidemiology and survival information is derived from case reports and case series.
Kartik Anand, Allyne M. Ensor, Joe E. Ensor   +2 more
doaj  

CD20 [PDF]

Science-Business eXchange, 2009
openaire   +2 more sources

CD20 tails interact with the 14-3-3/GEF-H1 complex and microtubule network upon PKCδ phosphorylation

The EMBO Journal
CD20 is a four-helix transmembrane protein specifically expressed in B-cells that serves as a prominent target of therapeutic anti-CD20 antibodies. It is localized in a membrane nanocluster harboring the B-cell antigen receptor of IgD class (IgD-BCR ...
Kathrin Kläsener, Cindy Eunhee Lee, Julian Bender, Angela Naumann, Lena Reimann, Geoffroy Andrieux, Claudio Mussolino, Nadja Herrmann, Roland Nitschke, Reinhard E Voll, Bettina Warscheid, Klaus Warnatz, Michael Reth   +12 more
doaj   +1 more source

CD20 [PDF]

Science-Business eXchange, 2011
openaire   +2 more sources