Results 51 to 60 of about 98,309 (302)

Characteristics and Outcomes of Male Participants in a Multicenter Longitudinal Australian Study Cohort

Arthritis Care &Research, EarlyView.
Objective The aim of this study was to determine the differences in demographic, serologic, and clinical characteristics between male and female patients with systemic sclerosis (SSc) in an Australian cohort. Methods This was a retrospective observational study using data from the Australian Scleroderma Cohort Study.
Emily Lin, Dylan Hansen, Laura Ross, Gene‐Siew Ngian, Susanna Proudman, Gabor Major, Maryam Tabesh, Mandana Nikpour, Jennifer Walker, Lauren Host, Nava Ferdowsi, Alannah Quinlivan, Wendy Stevens, Joanne Sahhar, Diane Apostolopoulos   +14 more
wiley   +1 more source

Change of CD20 Expression in Diffuse Large B-Cell Lymphoma Treated with Rituximab, an Anti-CD20 Monoclonal Antibody: A Study of the Osaka Lymphoma Study Group

Case Reports in Oncology, 2009
Change of CD20 expression was examined in cases of diffuse large B-cell lymphoma (DLBCL). CD20 expression after treatment with anti-CD20 antibody (rituximab, Rx) for DLBCL was examined in 23 cases who received serial biopsy by immunohistochemistry (IHC ...
Naoki Wada, Masaharu Kohara, Hiroyasu Ogawa, Haruo Sugiyama, Shirou Fukuhara, Yoichi Tatsumi, Akihisa Kanamaru, Masayuki Hino, Yuzuru Kanakura, Eiichi Morii, Katsuyuki Aozasa   +10 more
doaj   +1 more source

FOXO1 promotes resistance of non-Hodgkin lymphomas to anti-CD20-based therapy

, 2020
Diminished overall survival rate of non-Hodgkin lymphoma (NHL) patients treated with a combination regimen of rituximab, cyclophosphamide, doxorubicin, vincristine and prednisone (R-CHOP) has been recently linked to recurrent somatic mutations activating
Jakub Golab (88443), Dinis Calado (3744883), Michal Dwojak (9342560), Marcin M Machnicki (9342575), Abdessamad Zerrouqi (31596), Giulia Morlino (8848979), Malgorzata Bobrowicz (9342569), Dimitar G Efremov (9342587), Stefania Gobessi (9342578), Marta Siernicka (9342572), Magdalena Winiarska (88418), Nina Miazek (9342566), Piotr Zapala (9342563), Agnieszka Zagozdzon (4761018), Przemyslaw Juszczynski (9342590), Joanna Barankiewicz (9342581), Ewa Lech-Maranda (9342584), Beata Pyrzynska (9342557), Kamil Bojarczuk (3072240)   +18 more
core  

Decoding IGLL5 Mutation‐Mediated BCR Signaling: A Novel Mechanism of CD8+ T Cell Exhaustion and Ocular MALT Lymphoma Progression

Advanced Science, EarlyView.
OAML harbors recurrent IGLL5 mutations that reinforce CD79A/CD79B‐associated BCR signaling. Mechanistic analysis of the S47G and A54G variants reveals induction of CXCL10/CXCL11, enhanced CD8+ T‐cell recruitment, and exhaustion‐associated dysfunction, supporting an immune‐tolerant niche.
Andi Zhao, Haoyu Wei, Chenyu Zhou, Xinping Sun, Shuyan Da, Haiyu Liu, Zijin Wang, Hui Zhu, Shiya Shen, Qing Shao, Qi Gong, Hu Liu, Xuejuan Chen   +12 more
wiley   +1 more source

Can quantitative monitoring of B cells evaluate the efficacy of Rituximab in primary CNS demyelinating disorders?

Annals of Medical Science and Research
Introduction: Rituximab (RTX), initially approved for various blood cancers, is additionally used for the management of primary central nervous system (CNS) demyelinating disorders.
Sayan Chatterjee, Peyalee Sarkar, Mitali Chatterjee, Biman Kanti Ray   +3 more
doaj   +1 more source

Evaluating the difference in clinical efficacy for t(11;14) multiple myeloma patients with CD20- or CD20+

, 2023
Objective To examine the differences in therapy response and confirm the effective regimen for multiple myeloma (MM) patients with t (11; 14)/CD20- or CD20+, for the selection of transplantation as early treatment.
ZHAO Weihong, HUANG Bintao, LIU Rui, XIANG Caixia
core   +1 more source

Optimized Ex Vivo Human Liver Slice Culture Maintains Extended Viability and Function for Hepatotoxicity Testing

Advanced Science, EarlyView.
An optimized ex vivo human liver slice culture system preserves tissue architecture, hepatocyte function, and immune‐stromal complexity for at least five days. By refining slice thickness, oxygenation, air‐liquid interface, and extracellular matrix support, the platform enables human‐relevant hepatotoxicity testing and mechanistic studies, offering a ...
Huiche Feng, Cinzia Esposito, Andrej Benjak, Matthias S. Matter, Miriam Cieri, Camilla De Carlo, Philipp Sedlaczek, Fabian Haak, Mattia Marinucci, Gabriel Fridolin Hess, Otto Kollmar, Mairene Coto‐Llerena, Luca Di Tommaso, Visar Vela, Lukas Bubendorf, Luigi M. Terracciano, Charlotte K. Y. Ng, Salvatore Piscuoglio   +17 more
wiley   +1 more source

CD20-Positive B-Lymphocytes in the Reactive Tumor Microenvironment as an Independent Immunohistochemical Prognostic Factor in Nodular Sclerosis Classical Hodgkin Lymphoma

Клиническая онкогематология
Aim. To assess the prognostic value of CD20-positive B-lymphocytes in the reactive tumor microenvironment using histological specimens of lymph nodes from patients with nodular sclerosis classical Hodgkin lymphoma (cHL). Materials & Methods.
Maksim Sergeevich Minaev
doaj   +1 more source

Rewiring NADH Metabolism Through NQO1‐Mediated Redox Cycling for Targeted Follicular Lymphoma Therapy

Advanced Science, EarlyView.
ABSTRACT Follicular lymphoma (FL) remains an incurable B‐cell malignancy with high relapse rates, and conventional therapies are often limited by significant toxicity, highlighting the need for novel treatments. We identified that FL exhibits markedly low expression of NAD(P)H: quinone oxidoreductase 1 (NQO1), a key enzyme required for activating ...
Jinxing Zhang, Ziqi Wang, Ye Weng, Yulin Fu, Yuelong Jiang, Beilin Zhuang, Wenzi Zeng, Xiangchun Zhang, Bing Xu, Jie Zha, Hongjun Zhuang   +10 more
wiley   +1 more source

Prognostic Significance of Cancer Stem Cell Markers and Tumor Microenvironment Components for Assessing the Efficacy of Chemoradiotherapy in Patients with Locally Advanced rectal cancer

Инновационная медицина Кубани
Background: Despite the incorporation of neoadjuvant chemoradiotherapy into the standard treatment of locally advanced rectal cancer, significant variability in therapeutic response persists.
A. Yu. Georgieva, V. N. Bodnya, A. A. Verevkin   +2 more
doaj   +1 more source