Results 61 to 70 of about 98,309 (302)

Ocrelizumab Depletes CD20+ T Cells in Multiple Sclerosis Patients

Cells, 2018
Ocrelizumab, a humanized monoclonal anti-CD20 antibody, has shown pronounced effects in reduction of disease activity in multiple sclerosis (MS) patients and has recently been approved for the treatment of patients with relapsing MS (RMS) and primary ...
Stefan Gingele, Thais Langer Jacobus, Franz Felix Konen, Martin W. Hümmert, Kurt-Wolfram Sühs, Philipp Schwenkenbecher, Jonas Ahlbrecht, Nora Möhn, Lars H. Müschen, Lena Bönig, Sascha Alvermann, Reinhold E. Schmidt, Martin Stangel, Roland Jacobs, Thomas Skripuletz   +14 more
doaj   +1 more source

Characterization of the canine CD20 as a therapeutic target for comparative passive immunotherapy

Scientific Reports, 2022
Anti-CD20 therapies have revolutionized the treatment of B-cell malignancies. Despite these advances, relapsed and refractory disease remains a major treatment challenge.
Joana N. R. Dias, André Almeida, Ana S. André, Sandra I. Aguiar, Pedro Bule, Sara Nogueira, Soraia S. Oliveira, Belmira Carrapiço, Solange Gil, Luís Tavares, Frederico Aires-da-Silva   +10 more
doaj   +1 more source

Features of Human CD3(+)CD20(+) T Cells [PDF]

, 2016
Monoclonal Abs against CD20 reduce the number of relapses in multiple sclerosis (MS); commonly this effect is solely attributed to depletion of B cells. Recently, however, a subset of CD3(+)CD20(+) T cells has been described that is also targeted by the ...
Krane, M., Feil, K., Berer, K., Schuh, E., Pfannes, K., Krumbholz, M., Lange, R., Kuempfel, T., Hohlfeld, R., Mulazzani, M., Lahm, H., Subklewe, M., Meinl, E., Guerkov, R., Bradl, M., Meinl, I.   +15 more
core   +1 more source

sj-docx-1-msj-10.1177_13524585231161253 – Supplemental material for Humoral immune responses remain quantitatively impaired but improve qualitatively in anti-CD20-treated patients with multiple sclerosis after three or four COVID-19 vaccinations

, 2023
Supplemental material, sj-docx-1-msj-10.1177_13524585231161253 for Humoral immune responses remain quantitatively impaired but improve qualitatively in anti-CD20-treated patients with multiple sclerosis after three or four COVID-19 vaccinations by ...
Andi Krumbholz (11906355), Moritz Niederschweiberer (12550592), Christian Drosten (58071), Tatjana Schwarz (9911085), Lara M Jeworowski (14852650), Klemens Ruprecht (187598), Ruben Rose (11983026), Marie L Schmidt (14852653), Patrick Schindler (8081684), Carolin Otto (3913126), Victor M Corman (12059501), Florence Pache (789593), Felix Walper (14129713)   +12 more
core   +1 more source

A Catalytic Osmium Redox Couple Collapses Cancer Redox Balance

Advanced Science, EarlyView.
A stable Os(III)/Os(IV) redox couple is developed to disrupt the tumor cell redox balance by concurrently catalyzing ROS generation and GSH depletion. Osmium‐treated cells exhibit multiple cell death pathways, including apoptosis, ferroptosis, and immunogenic cell death.
Wan‐Qiong Huang, Tao Huang, Yiming Hao, Gui‐Feng Huang, Yi‐Lang Yan, Xin Fang, Ying Chen, Xiao‐Long Wei, Wai‐Lun Man, Wen‐Xiu Ni   +9 more
wiley   +1 more source

Noninvasive Characterization of Tumor Heterogeneity in HNSCC: From Clinical Utility to Biological Correlates

Advanced Science, EarlyView.
This study establishes a CT‐based radiomics framework to quantify intratumoral heterogeneity (ITH) in HNSCC. Using unsupervised clustering, tumor ROIs and VOIs are analyzed to calculate 2D/3D ITH scores. The score shows strong predictive value for prognosis and immunotherapy response, and is associated with tumor metabolism and immune microenvironment,
Xinwei Chen, Rui Liu, Yuan Zhou, Yin Xiao, Chengmin Feng, Lin Chen, Yanshi Li, Mengna Wang, Zhaobo Cheng, Yuxi Luo, Long Liu, Lijing Niu, Yue Xiang, Juan Peng, Guohua Hu, Min Pan   +15 more
wiley   +1 more source

Immune cells and tryptophan metabolism in the joint capsule tissue in rheumatoid arthritis

Acta Biomedica Scientifica
To the present day, many links in the pathogenesis of rheumatoid arthritis remain unclear, which leads to unsatisfactory results in its therapy.The aim.
E. A. Stepanov
doaj   +1 more source

A Case of Cd20 Positive Mediastinal Rhabdomyosarcoma [PDF]

Turkish Journal of Pathology, 2012
We present the case of a 16-year-old boy admitted with a large mediastinal mass. Both in the mediastinal tru-cut biopsy and the bone marrow biopsy, a malignant small round cell tumor was determined. The clinical diagnosis was leukemia or lymphoma.
Gülden, Dınız, Ferah, Genel, Nur, Yücel, Ayşen, Türedı, Canan, Vergın   +4 more
openaire   +2 more sources

HLA‐DR+ Schwann Cells Generate the Protumor Cancer‐Neuron‐Immune Niche in Head and Neck Squamous Cell Carcinoma

Advanced Science, EarlyView.
Hijacked and educated by HNSCC cells, HLA‐DR+ Schwann cells lost their normal neural‐related functions but acquired immunoregulatory phenotypes to promote CD4+ T cells transform into Tregs. HLA‐DR+ Schwann cells induced a macrophage subpopulation, Il1β.
Xiaoyan Meng, Zhonglong Liu, Shijian Zhang, Luoman Gan, Liren Cao, Jingjing Sun, Lingfang Zhang, Yue He   +7 more
wiley   +1 more source

Functional characterization of murine cd20

, 2012
Bibliography: p. 189-232A few pages are in colour.CD20 is a tetraspanning membrane protein that is expressed on B lymphocytes, and functions in B cell receptor (BCR)-mediated calcium entry. The effect of murine CD20 deficiency on calcium mobilization was
Morsy, Deyaa El Deen
core   +1 more source