Results 81 to 90 of about 106,748 (296)

Single‐Cell Profiling Reveals Clonally Expanded CX3CR1+ T Cells in Anti‐NMDA Receptor Encephalitis

Advanced Science, EarlyView.
CX3CR1+ T cells are associated with peripheral and central immune alterations in anti‐NMDA receptor encephalitis (NMDAR‐E). They show potential responsiveness to GluN1 (NR1) peptides, potential interactions with peripheral B cells, clonal expansion, increased CD137/CD154 expression, and inflammatory cytokine production. Their preferential cerebrospinal
Lin Yan, Erdi Zhang, Yuwen Ma, Zirui Meng, Sisi Li, Yimeng Ren, Xiaohe Tian, Yangyi He, Giuseppe Battaglia, Dong Zhou, Yun Liao, Binwu Ying, Jinmei Li, Minjin Wang   +13 more
wiley   +1 more source

CD20-positive multiple myeloma complicated by cold agglutinin disease

Gülhane Tıp Dergisi
Cluster of differentiation 20 (CD20) expression is rarely observed in multiple myeloma (MM) and is typically associated with immature plasma cell morphology and aggressive clinical behavior.
Dilek Keskin, Hasan Can Özer, Özlem Candan, Ali Yılmaz Altay, Murat Akarsu   +4 more
doaj   +1 more source

IRF8 regulates efficacy of therapeutic anti‐CD20 monoclonal antibodies

, 2022
International audienceAnti-CD20 monoclonal antibodies such as Rituximab, Ofatumumab, and Obinutuzumab are widely used to treat lymphomas and autoimmune diseases. They act by depleting B cells, mainly through Fc-dependent effectors functions.
Anne Biton, Mouquet, Hugo, Rachel Legendre, Cyril Planchais, Timothée Bruel, Marco Vignuzzi, Olivier Schwartz, Commère, Pierre‐Henri, Amaury Vaysse, Porrot, Françoise, Hugo Mouquet, Planchais, Cyril, Legendre, Rachel, Ferdinand Roesch, Vignuzzi, Marco, Schwartz, Olivier, Biton, Anne, Ludivine Grzelak, Roesch, Ferdinand, Grzelak, Ludivine, Vaysse, Amaury, Bruel, Timothée, Françoise Porrot, Pierre‐Henri Commère   +23 more
core   +1 more source

Upadacitinib Restrains the Pathogenic Fitness of CD4+ T Cells and Aberrant B Cell Programming in Optic Neuritis

Advanced Science, EarlyView.
Single‐cell profiling and functional perturbation reveal coordinated JAK1‐pSTAT3 downstream programs in optic neuritis, including MCL1‐dependent fitness of pathogenic CD4+ Tem cells and glycolysis‐linked, cholesterol‐sensitive B‐cell responses associated with RORA. Upadacitinib disrupts this reciprocal T‐B‐cell circuit and alleviates neuroinflammation,
Gengchen Jiang, Qi Jiang, Lian Han, Yue Peng, Xingyu Liu, Tong Yang, Hao Huang, Jiaying Liu, Yuan Gao, Hui Yang, Wenjun Zou, Zhaohuai Li, Wenru Su   +12 more
wiley   +1 more source

AASLD practice guidance on drug, herbal, and dietary supplement–induced liver injury

, 2022
Hepatology, EarlyView.
Robert J. Fontana, Iris Liou, Adrian Reuben, Ayako Suzuki, M. Isabel Fiel, William Lee, Victor Navarro   +6 more
wiley   +1 more source

Targeting CD20 in chronic lymphocytic leukemia

, 2015
Myrna R Nahas, Jon E ArnasonBeth Israel Deaconess Medical Center, Boston, MA, USAAbstract: Chronic lymphocytic leukemia (CLL), the most common leukemia in adults, is standardly managed with chemotherapy in combination with the anti-CD20 antibody ...
Nahas MR, Arnason JE
core  

Wie das Membranprotein CD20 humane B-Lymphozyten ruhig hält

, 2022
The membrane protein CD20 of B lymphocytes is the target of Rituximab (RTX), the first successful therapeutic antibody. The biological function of CD20 was a mystery so far.
Reth, Michael, Kläsener, Kathrin
core   +1 more source

Single‐Cell Transcriptomic Profiling Identifies B Cell‐Intrinsic Dysregulation of Sphingolipid Biosynthesis and Could Be Improved by Inhibiting UGCG in Primary Immune Thrombocytopenia

Advanced Science, EarlyView.
This study generates the single‐cell atlas of pathogenic B‐cell subset Bc‐5 in ITP. It identifies RUNX3 as a key survival regulator and uncovers sphingolipid‐driven metabolic reprogramming, validating UGCG inhibition as a therapeutic candidate and building a valuable resource for ITP mechanistic and therapeutic exploration.
Dongmei Luo, Yanxia Zhan, Lili Ji, Pengcheng Xu, Pu Chen, Hao Pang, Yunan Ling, Fanli Hua, Xibing Zhuang, Hao Chen, Yunfeng Cheng   +10 more
wiley   +1 more source

Ofatumumab: a novel monoclonal anti-CD20 antibody

, 2010
Thomas S LinGlaxoSmithKline Oncology R&D, Collegeville, PA, USAAbstract: Ofatumumab, a novel humanized monoclonal anti-CD20 antibody, was recently approved by the FDA for the treatment of fludarabine and alemtuzumab refractory chronic lymphocytic
Thomas S Lin
core  

CD20 as target for immunotherapy [PDF]

, 2019
Most lymphomas and leukemias are neo¬plasms of B cells. Due to the many different B cell development stages from which these neoplasms arise, the resulting diseases are quite heterogeneous, which amongst other things is manifested in different tumor ...
Engelberts, P.J.
core