Results 91 to 100 of about 98,309 (302)

CD20 monoclonal antibody targeted nanoscale drug delivery system for doxorubicin chemotherapy: an in vitro study of cell lysis of CD20-positive Raji cells

, 2016
Shuang Jiang,1,2,* Xiaobo Wang,2,* Zhiran Zhang,2 Lan Sun,3 Yunzhu Pu,3 Hongjuan Yao,3 Jingcao Li,3 Yan Liu,3 Yingge Zhang,3 Weijing Zhang1,4 1Department of Lymphoma, Affiliated Hospital of the Military Medical Academy of Sciences, Beijing, 2Department ...
Sun L, Zhang W, Liu Y, Li J, Zhang Z, Zhang Y, Pu Y, Jiang S, Wang X, Yao H   +9 more
core  

Expression of CD20-CAR.

, 2013
(A) Flow cytometric examination of surface expression of the CD20-CAR and CD19. Mock, non-transduced T cells. The CAR was detected with a PE-conjugated mouse anti-human IgG (Fc-specific) antibody. CD19 expression was detected with an APC conjugated mouse
Jinjuan Wang (498583), Carolina Berger (281816), Shaunda A. Brouns (498586), Stanley R. Riddell (168956), David M. Spencer (186092), Michael C. Jensen (327373), Shani E. Frayo (498585), Yukang Lin (498582), Oliver W. Press (498588), Lihua E. Budde (498581), Brian G. Till (498587), Xubin Lin (498584)   +11 more
core   +1 more source

Single‐Cell Level Characterization of B Cell Depletion and Repopulation Following Rituximab in Systemic Lupus Erythematosus

Arthritis &Rheumatology, EarlyView.
Objective Rituximab, a CD20+ B cell depletion therapy, is frequently used to treat systemic lupus erythematosus (SLE). However, variability in patient response highlights the need for a deeper understanding of the underlying immune cell dynamics of B cell depletion and repopulation.
Haerin Jang, Norzawani Buang, Catherine Sutherland, Wanseon Lee, Lauren Overend, Tarran S. Rupall, Katie L. Burnham, Matthew C. Pickering, Marina Botto, Emma E. Davenport   +9 more
wiley   +1 more source

Dinámica de Linfocitos T en Autoinmunidad. Línea de investigación: Neurociencias clínicas y experimentales [PDF]

, 2013
[esp] La Esclerosis Multiple (EM) se ha considerado una enfermedad autoinmune mediada por linfocitos T con un comportamiento oscilatorio prototípico, caracterizado por la presencia de brotes clínicos. Por tanto, comprender la dinámica de las células del
Martínez Pasamar, Sara
core  

Kidney Hematopoietic Stem and Progenitor Cells Contribute to Myeloid Development and Pathology in Lupus Nephritis

Arthritis &Rheumatology, EarlyView.
Objective The hematopoietic system maintains homeostasis by balancing myeloid and lymphoid cell production in the bone marrow (BM). In response to increased hematopoietic demand, extramedullary hematopoiesis (EMH) may occur in nonlymphoid organs. We investigated the role of EMH and kidney‐resident hematopoietic stem and progenitor cells (HSPCs) in ...
Hansol Yi, Seyoung Jung, Jeong Ho Joo, Young‐Eun Kim, Heounjeong Go, Yong‐Gil Kim, Chang‐Keun Lee, Bin Yoo, Jeong Seok Lee, Seokchan Hong   +9 more
wiley   +1 more source

Isolation of a mouse CD20-specific monoclonal antibody that can recognize human and canine CD20 protein.

, 2016
(A). Amino acid sequence of human and canine CD20 surrounding the Rituximab epitope. The asterisks highlight divergence between human (hCD20) and canine (cCD20) proteins. (B). Immunoblotting of recombinant canine CD20 protein.
David Argyle (2147059), Borek Vojtesek (2147047), Euan Murray (1814974), Eva Ruckova (723397), Luca Aresu (330811), John Clayton (2147056), Ted R. Hupp (141798), Sandra Hemmington (2147050), Asmare A. Limeneh (2147053), Jianguo Shi (29330), Stefano Comazzi (546092), William Humphries (2147062), Erin Worrall (2147065), Robin Fahraeus (252177), Paul Davis (5775), Saurabh Jain (1864498), Petr Muller (525929), Kathryn Ball (1840120)   +17 more
core   +1 more source

Differences in SARS‐CoV‐2 Antigen Persistence in Individuals With Systemic Autoimmune Rheumatic Diseases Compared to the General Population: A RECOVER‐Adult Cohort Study

Arthritis &Rheumatology, EarlyView.
Objective Individuals with systemic autoimmune rheumatic diseases (SARDs) are at risk for worse acute and post–acute COVID‐19 outcomes, though whether individuals with SARDs have longer persistence of viral antigens after COVID‐19 has not been studied.
Naomi J. Patel, Zoe Swank, Jiaqi Wang, Xiaosong Wang, Lauren A. O'Keeffe, Madison Negron, Liya S. Getachew, Louise L. Hansen, Grace Qian, Alene A. Saavedra, Kevin T. Mueller, Natalie A. Davis, Kathleen M. M. Vanni, Sandria Savage, Julie S. Lam, Zachary S. Wallace, David R. Walt, Jeffrey A. Sparks, on behalf of RECOVER‐Adult   +18 more
wiley   +1 more source

Zielgerichteter Zelleintritt lentiviraler Vektoren

, 2009
Lentiviral vectors mediate gene transfer into dividing and most non-dividing cells. Thereby, they stably integrate the transgene into the host cell genome. For this reason, lentiviral vectors are a promising tool for gene therapy.
Funke, Sabrina
core  

Two structurally different rituximab-specific CD20 mimotope peptides reveal that rituximab recognizes two different CD20-associated epitopes [PDF]

, 2009
Peptide mimotopes of the CD20 epitope recognized by rituximab are useful tools for studying this therapeutic mAb's functional properties. We previously identified two structurally different peptides that are both effective mimotopes: a 7-mer cyclic ...
Guarnera A, Dammacco F., FAVOINO, ELVIRA, De Pinto V, PEROSA, Federico, Vicenti C, RACANELLI, Vito   +6 more
core   +1 more source

Expert Perspectives: Defining and Managing Progressive Pulmonary Fibrosis in Systemic Sclerosis

Arthritis &Rheumatology, EarlyView.
Systemic sclerosis–associated interstitial lung disease (SSc‐ILD) is one of the leading causes of morbidity and mortality in SSc, affecting up to three‐quarters of patients. The disease course is highly heterogeneous, ranging from indolent, nonprogressive forms to rapidly progressive pulmonary fibrosis (PPF).
Devis Benfaremo, Dinesh Khanna, Corrado Campochiaro, Vincent Cottin, Fabrizio Luppi, Marco Matucci‐Cerinic, Gianluca Moroncini, Yannick Allanore   +7 more
wiley   +1 more source