Results 91 to 100 of about 106,748 (296)

A Spatiotemporal Single‐Cell Atlas Uncovers Dysregulated ECM Dynamics and Septal Remodeling Arrest in Human Ventricular Septal Defects

Advanced Science, EarlyView.
Integrating single‐cell and spatial transcriptomics reveals human ventricular septal defect (VSD) as a disease of microenvironmental insufficiency and structural remodeling arrest. Attenuated endothelial‐fibroblast crosstalk, alongside downregulated THBS1/TGF‐β1 and MMP2 signaling networks, impairs the endothelial‐to‐mesenchymal transition (EndoMT) and
Xiaoyuan Zhang, Lun Zhu, Ze Sun, Ruolin Jia, Ziming Wang, Jiayao Zhao, Bohao Liu, Haiqing Xiong, Xiaowei Yu, Yanzhu Yue   +9 more
wiley   +1 more source

Construction and characterization of an anti-CD20 mAb nanocomb with exceptionally excellent lymphoma-suppressing activity

, 2015
Hua-Fei Li,1–3,* Cong Wu,4,* Ting Chen,5,* Ge Zhang,1 He Zhao,1 Chang-Hong Ke,1 Zheng Xu21International Joint Cancer Institute, Translation Medicine Institute, 2Planning Division, Scientific Research Department, 3Tumor Immunology and Gene Therapy ...
Zhang G, Li H, Wu C, Xu Z,, Ke C, Chen T, Zhao H   +6 more
core  

Expression of CD20-CAR.

, 2013
(A) Flow cytometric examination of surface expression of the CD20-CAR and CD19. Mock, non-transduced T cells. The CAR was detected with a PE-conjugated mouse anti-human IgG (Fc-specific) antibody. CD19 expression was detected with an APC conjugated mouse
Jinjuan Wang (498583), Carolina Berger (281816), Shaunda A. Brouns (498586), Stanley R. Riddell (168956), David M. Spencer (186092), Michael C. Jensen (327373), Shani E. Frayo (498585), Yukang Lin (498582), Oliver W. Press (498588), Lihua E. Budde (498581), Brian G. Till (498587), Xubin Lin (498584)   +11 more
core   +1 more source

CD20 Antibody Primes B Lymphocytes for Type I Interferon Production [PDF]

, 2013
CD20 is a B cell surface marker that is expressed in various stages in B lymphocytes and certain lymphomas. Clinical administration of CD20 antibody, such as rituximab, is used widely to treat human B-cell lymphomas and other diseases.
Zhang, Luwen, Xu Dongsheng, Xu, Dongsheng, Staedman, Andrew, Luwen Zhang, Staedman Andrew, Zhang Luwen, Dongsheng Xu, Andrew Staedman   +8 more
core   +2 more sources

CD86‐Positive Mature Tertiary Lymphoid Structures Are Associated With CD8+ T‐Cell Infiltration and Favorable Clinical Outcomes in Pancreatic Ductal Adenocarcinoma

Annals of Gastroenterological Surgery, EarlyView.
CD86‐positive mature tertiary lymphoid structures were associated with increased intratumoral CD8+ T‐cell infiltration, a higher proportion of Granzyme B‐expressing CD8+ T cells in an exploratory analysis, and favorable clinical outcomes in pancreatic ductal adenocarcinoma.
Takaomi Seki, Kenichiro Araki, Takehiko Yokobori, Hayato Ikota, Norio Kubo, Takamichi Igarashi, Mariko Tsukagoshi, Norihiro Ishii, Yasuo Hosouchi, Hiroshi Saeki, Ken Shirabe   +10 more
wiley   +1 more source

Dual-trigger model of CD20 escape: NONO regulation and cryptic splicing induced by transcript overload in pediatric B-ALL

Frontiers in Immunology
IntroductionThe B-cell-specific marker CD20 is expressed in various B-cell malignancies, including B-cell acute lymphoblastic leukemia (B-ALL) and serves as a key target for immunotherapies.
Moein Kermani, Sebastian Maxeiner, Francesca Alt, Nicole Ziegler, Julian König, Claudia Paret, Claudia Paret, Claudia Paret, Jörg Faber, Jörg Faber, Jörg Faber   +10 more
doaj   +1 more source

Retroviral transfer of human CD20 as a suicide gene for adoptive T-cell therapy

Haematologica, 2009
The aim of adoptive T-cell therapy of cancer is to selectively confer immunity against tumor cells. Autoimmune side effects, however, remain a risk, emphasizing the relevance of a suicide mechanism allowing in vivo elimination of infused T cells.
Marieke Griffioen, Esther H.M. van Egmond, Michel G.D. Kester, Roel Willemze, J.H. Frederik Falkenburg, Mirjam H.M. Heemskerk   +5 more
doaj   +1 more source

Scintigraphic acquisition of athymic Nude mice bearing CD20+ (R) and CD20- (L) xenografts.

, 2015
Mice were grafted with tumor CD20+ on right flank (R, dark gray arrow) and CD20- on left flank (L, light gray head arrow). Mice were injected intravenously with 35–37 MBq of 99mTc anti-CD20 IgG-SH (A), 99mTc anti-EGFR IgG-SH (B) or 99mTc-anti-IsoLink® (C)
Isabelle Quelven (803908), Hélène Carpenet (803906), Jacques Monteil (803907), Armelle Cuvillier (40496)   +3 more
core   +1 more source

Chromosomal Abnormalities, Drug Sensitivity and Resistance in Hematological Malignancies: A Comprehensive Overview by the Francophone Group of Hematological Cytogenetics (GFCH)

American Journal of Hematology, EarlyView.
ABSTRACT Chromosomal abnormalities have a major clinical impact on hematological malignancies, particularly with regard to treatment strategies. To preserve and consolidate fundamental knowledge in this rapidly evolving field, the Francophone Group of Hematological Cytogenetics (Groupe Francophone de Cytogénétique Hématologique, GFCH) conducted a ...
Florence Nguyen‐Khac, Audrey Bidet, Elise Chapiro, Nathalie Douet‐Guilbert, Jean‐Baptiste Gaillard, Nada Assaf, Nathalie Auger, Hend Chaker, Jasmine Chauzeix, Inge Govaerts, Hippolyte Guérineau, Christine Lefebvre, Pauline Roynard, Hélène Guermouche, Lucienne Michaux, Marie‐Bérengère Troadec, Lauren Véronèse   +16 more
wiley   +1 more source

Expression and folding of CD20 in the E. coli inner membrane.

, 2012
Cell surface expression and orientation of CD20 was assessed from spheroplasts of E. coli cells expressing either Uni-CD20 (blue), LE-CD20 (green) or an empty control vector (red) treated with Alexa-488 conjugated anti-CD20 antibody to the extracellular ...
Jenny Bostrom (168293), Chingwei V. Lee (168302), Arthur Huang (168306), Hok Seon Kim (168284), James A. Ernst (168286), Cecilia Brown (168289), Daniel G. Yansura (168317), Richard L. Vandlen (168312), Germaine Fuh (168297)   +8 more
core   +1 more source