Results 111 to 120 of about 220,756 (241)

Optimal proportion CD34⁺ cells to CD34⁻ cells for effective EPC differentiation.

, 2014
The optimal proportion of CD34+ cells to CD34− cells was estimated by coculture of CD34+ cells (500 cells per 35-mm dish) with various densities of CD34− cells (100, 50, 20, 10, 5, 2.5, 1.7, 1.25, 1, 0.3, and 0% of CD34+ cells).
Da-Yeon Kim (622779), Ji-Hye Park (284710), So-Young Yoo (622781), Hwi-Gon Kim (622786), Jong-Kyu Hong (622782), Jung-Hee Kim (77641), Sang-Mo Kwon (172513), Yeon-Ju Kim (622784), Song-Hwa Kang (622780), Sun-Jin Lee (622785), Takayuki Asahara (191004), Sang-Hun Lee (172506), Jun-Hee Lee (172509), Sung-Wook Kim (622783), Seok-Yun Jung (172501)   +14 more
core   +1 more source

Kidney Hematopoietic Stem and Progenitor Cells Contribute to Myeloid Development and Pathology in Lupus Nephritis

Arthritis &Rheumatology, EarlyView.
Objective The hematopoietic system maintains homeostasis by balancing myeloid and lymphoid cell production in the bone marrow (BM). In response to increased hematopoietic demand, extramedullary hematopoiesis (EMH) may occur in nonlymphoid organs. We investigated the role of EMH and kidney‐resident hematopoietic stem and progenitor cells (HSPCs) in ...
Hansol Yi, Seyoung Jung, Jeong Ho Joo, Young‐Eun Kim, Heounjeong Go, Yong‐Gil Kim, Chang‐Keun Lee, Bin Yoo, Jeong Seok Lee, Seokchan Hong   +9 more
wiley   +1 more source

Identification of CD34+ and CD34- leukemia-initiating cells in MLL-rearranged human acute lymphoblastic leukemia.

, 2015
Translocation of the mixed-lineage leukemia (MLL) gene with AF4, AF9, or ENL results in acute leukemia with both lymphoid and myeloid involvement.
Mizutani, Shuki, Saito, Yoriko, Yuki Aoki, Rintaro Ono, Suzuki, Nahoko, Akiko Kaneko, Eguchi-Ishimae, Minenori, Mariko Eguchi, Shultz, Leonard D, Shuki Mizutani, Aoki, Yuki, Ono, Rintaro, Yoriko Saito, Tomizawa, Daisuke, Daisuke Tomizawa, Fujiki, Saera, Minenori Eguchi-Ishimae, Eguchi, Mariko, Katsuyoshi Koh, Koh, Katsuyoshi, Ishikawa, Fumihiko, Osamu Ohara, Saera Fujiki, Hijikata, Atsushi, Ishii, Eiichi, Takashi Watanabe, Sato, Kaori, Yoko Kuroki, Kaori Sato, Ohara, Osamu, Masatoshi Takagi, Leonard D. Shultz, Nahoko Suzuki, Fumihiko Ishikawa, Watanabe, Takashi, Kuroki, Yoko, Takagi, Masatoshi, Atsushi Hijikata, Eiichi Ishii, Kaneko, Akiko   +39 more
core   +2 more sources

MEK inhibitor PD0325901 upregulates CD34 expression in endothelial cells via inhibition of ERK phosphorylation

Regenerative Therapy
Introduction: CD34-positive endothelial progenitor cells (EPCs) promote angiogenesis and are a promising tool for regenerative cell therapy of ischemic diseases.
Chihiro Hosoda, Seiji Mitani, Asuka Sakata, Shogo Kasuda, Yu Onodera, Yoko Takabayashi, Midori Shima, Kohei Tatsumi   +7 more
doaj   +1 more source

CD34 Antigen and the MPL Receptor Expression Defines a Novel Class of Human Cord Blood-Derived Primitive Hematopoietic Stem Cells

Cell Transplantation, 2017
In the murine hematopoietic stem cell (HSC) compartment, thrombopoietin (THPO)/MPL (THPO receptor) signaling plays an important role in the maintenance of adult quiescent HSCs.
Yoshikazu Matsuoka, Masaya Takahashi, Keisuke Sumide, Hiroshi Kawamura, Ryusuke Nakatsuka, Tatsuya Fujioka, Yoshiaki Sonoda M.D., Ph.D.   +6 more
doaj   +1 more source

E-cadherin/CD34 double immunostaining in placental diagnosis

Placental foetal vascular malperfusion (FVM) may be responsible for complicated foetal or neonatal condition. By highlighting endothelial fragmentation, the double E-cadherin/CD34 immunostain highlights distal villous endothelial fragmentation of recent ...
Jerzy Stanek
core   +1 more source

Human Fibroblast–Myeloid Cell Tissue Atlas Across the Lungs, Synovium, Skin, and Heart

Arthritis &Rheumatology, EarlyView.
Objective The availability of single‐cell RNA sequencing (scRNAseq) data in different tissues and disease states provides an opportunity to compare cellular subsets and identify common and unique cellular activation. In this study, we aimed to characterize shared and tissue‐specific myeloid and stromal phenotypes and to uncover key cellular subtypes ...
Lucy MacDonald, Katerina Apostolopoulou, Olympia Hardy, Melpomeni Toitou, Gabriela Kania, Przemyslaw Blyszczuk, Raphael Micheroli, Thomas D. Otto, Mariola Kurowska‐Stolarska, Caroline Ospelt   +9 more
wiley   +1 more source

Design and Validation of an Automated Process for the Expansion of Peripheral Blood‐Derived CD34+ Cells for Clinical Use After Myocardial Infarction

Stem Cells Translational Medicine, 2019
We previously demonstrated that intracardiac delivery of autologous peripheral blood‐derived CD34+ stem cells (SCs), mobilized by granulocyte‐colony stimulating factor (G‐CSF) and collected by leukapheresis after myocardial infarction, structurally and ...
Claire Saucourt, Sandrine Vogt, Amandine Merlin, Christophe Valat, Anthony Criquet, Laurence Harmand, Brigitte Birebent, Hélène Rouard, Christian Himmelspach, Éric Jeandidier, Anne‐Gaële Chartois‐Leauté, Sophie Derenne, Laurence Koehl, Joe‐Elie Salem, Jean‐Sébastien Hulot, Céline Tancredi, Anne Aries, Sébastien Judé, Eric Martel, Serge Richard, Luc Douay, Philippe Hénon   +21 more
doaj   +1 more source

CD248/Endosialin Regulates Synovial Fibroblast State to Control Coupling of Inflammation and Bone Damage in Murine Models of Immune‐Mediated Inflammatory Arthritis and Aging

Arthritis &Rheumatology, EarlyView.
Objective Synovial fibroblasts directly contribute to inflammation and damage in immune‐mediated inflammatory arthritis. CD248/endosialin is expressed by fibroblasts in the synovium, is highly up‐regulated during inflammation, and has been proposed as a potential therapeutic target.
Samuel Kemble, Corinna Wehmeyer, James M. Brown, Charlotte G. Smith, Holly R. Adams, Eva Crombie, Ellie Northall, Maryam Imran, Paulynn Chin, Harris R. Perlman, Christopher D. Buckley, Adam P. Croft, Amy J. Naylor   +12 more
wiley   +1 more source

Tumor size in Cd34^−/− surpasses Cd34^+/+ by day 19, due to hematopoietic loss of CD34.

, 2013
A, Average s.c.-injected tumor masses 19 days post-injection in Cd34+/+ and Cd34−/− animals. (Pooled from three experiments, Cd34+/+ n = 15, Cd34−/− n = 16).
Andrew I. Minchinton (353466), Steven Maltby (353460), Matthew J. Gold (353464), Michael R. Gold (353467), Calvin D. Roskelley (24471), Kelly M. McNagny (24472), Spencer Freeman (353462), Jennifer H. E. Baker (353465)   +7 more
core   +1 more source