Results 121 to 130 of about 220,756 (241)

Implementation and use of risk minimization control tools in the EU: A multistakeholder survey

British Journal of Clinical Pharmacology, EarlyView.
Aims This study characterized stakeholders' experiences with national implementation of risk minimization control tools (RMCTs), such as healthcare professional qualification, healthcare facility accreditation and medical intervention prior to treatment initiation, for eight medicinal products across eight European Union countries. Methods We conducted
Sharon C. M. Essink, Iris R. Joosse, Maximilian Salcher‐Konrad, Melanie Walter, Elena Deligianni, Dimitra Tsioumela, Christos Kontogiorgis, Elita Poplavska, Iluta Žīgure, Christina E. Hoeve, Teresa Leonardo Alves, Ella D. van Vliet, Renato Ferreira‐da‐Silva, Ana Kodrič, Mitja Kos, Juan Erviti, Marta Gutiérrez‐Valencia, Luis Carlos Saiz, Sofia Kälvemark Sporrong, Emelie Karlsson, Christine Leopold, Marie L. De Bruin   +21 more
wiley   +1 more source

Antifibrotic Activity of Human Placental Amnion Membrane-Derived CD34(+) Mesenchymal Stem/Progenitor Cell Transplantation in Mice With Thioacetamide-Induced Liver Injury

, 2017
Liver fibrosis represents the end stage of chronic liver inflammatory diseases and is defined by the abnormal accumulation of extracellular matrix in the liver. Advanced liver fibrosis results in cirrhosis, liver failure, and portal hypertension.
Lee, Po-Huang;Tu, Chi-Tang;Hsiao, Chih-Chiang;Tsai, Ming-Song;Ho, Cheng-Maw;Cheng, Nai-Chen;Hung, Tzu-Min;Shih, Daniel Tzu-Bi, 何承懋;鄭乃禎;李伯皇   +1 more
core   +1 more source

Affinity Peptides With pH Sensitivity for the Enrichment of CD38+ Cells

Biotechnology and Bioengineering, EarlyView.
ABSTRACT The selective enrichment of cell populations based on surface markers is critical for the advancement of gene and cell therapies. Current antibody‐based cell isolation methods, such as fluorescence‐ and magnetic‐activated cell sorting (FACS and MACS), offer high specificity but are limited by scalability, cost, and potential adverse effects on
Gabrielle Rusch, Mickael Meyer, I. Mohamed Irfan, Carson Huber, Joseph Burclaff, Scott T. Magness, Stefano Menegatti, Michael Daniele   +7 more
wiley   +1 more source

МОРФОФУНКЦИОНАЛЬНЫЕ ИЗМЕНЕНИЯ ПЛАЦЕНТЫ И ЭКСПРЕССИЯ ЭНДОТЕЛИАЛЬНОГО МАРКЕРА СD34+ У БЕРЕМЕННЫХ С САХАРНЫМ ДИАБЕТОМ 1-ГО И 2-ГО ТИПОВ

Мать и дитя в Кузбассе
На сегодняшний день, несмотря на значительные достижения в ведении беременных с сахарным диабетом 1-го и 2-го типов, профилактике акушерских осложнений, проблема перинатальной заболеваемости и смертности остается по прежнему актуальной. Цель исследования
Юлия Алексеевна Дударева, Дарья Николаевна Сероштанова, Анастасия Валентиновна Песоцкая   +2 more
doaj  

The ALDH activity of CD34+CD38– HSC is higher than the CD34– bulk in CD34-negative AML.

, 2013
The aldefluor assay was performed on the bulk of cells (AML-464). Cells were subsequently labeled with anti-CD45 PERCP, anti-CD34 PC7, anti-CD38 APC and anti-CD56 PE. (A) The CD34+CD38– stem cells (A, left panel, orange) were negative for CD56 (A, middle
Lisa A. Min (482349), Gerrit J. Schuurhuis (482346), Monique Terwijn (482350), Nick A. de Jonge (482351), Alexander N. Snel (482353), Sonja Zweegman (482354), Gert J. Ossenkoppele (168366), Floris Wouters (482348), Michael H. Meel (482347), Linda Smit (482355), Angele Kelder (482352)   +10 more
core   +1 more source

Extracellular Vesicles‐Based Biological Macromolecule Delivery Systems: Biogenesis, Characterization, and Emerging Clinical Applications

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Extracellular vesicles (EVs) are nanoscale membrane‐bound structures that play a pivotal role in intercellular communication by transporting bioactive molecules, including proteins, lipids, nucleic acids, and organelles, between cells. Originating from the endosomal pathway, EVs reflect the physiological and pathological status of their parent
Emine İncilay Torunoğlu, Zeynep Betül Sarı, Muhammed Emin Sarı, Erdi Can Aytar   +3 more
wiley   +1 more source

Variability in responsiveness to lovastatin of the primitive CD34(+) AML subfraction compared to normal CD34(+) cells

, 2008
In the present study, we questioned whether the cholesterol synthesis inhibitor lovastatin potentiates the cytotoxicity of chemotherapeutic agents in the primitive CD34(+) subpopulation of acute myeloid leukemia (AML) cells. AML mononuclear cells (n = 17)
Sluiter, Wim J., de Vries, Elisabeth G. E.; id_orcid, Edo Vellenga, Susan D. P. W. M. de Jonge-Peeters, Folkert Kuipers, van der Weide, Karen, Wim J. Sluiter, Jonge-Peeters, Susan D. P. W. M., Karen van der Weide, de Vries, Elisabeth G. E., Kuipers, Folkert, Weide, Karen, Kuipers, Folkert; id_orcid, de Jonge-Peeters, Susan D. P. W. M., Elisabeth G. E. de Vries, Vellenga, Edo, Vries, Elisabeth G. E.   +16 more
core   +1 more source

Biomaterials for modulating cellular responses of endogenous tendon stem/progenitor cells: A promising avenue for tendon regeneration

BMEMat, EarlyView.
This review comprehensively summarizes emerging biomaterial‐based strategies and underlying mechanisms for modulating endogenous tendon stem/progenitor cells (TSPCs). It offers the most recent insights into TSPC physiology and potential applications of tissue engineering and regenerative medicine in tendons.
Zeyu Zhu, Renwang Sheng, Mumin Cao, Ludvig J. Backman, Yucheng Gao, Hao Wang, Cheng Zhang, Jialin Chen, Wei Zhang, Yunfeng Rui   +9 more
wiley   +1 more source

Transient loading of CD34+ hematopoietic progenitor cells with polystyrene nanoparticles

, 2017
Sarah Deville,1,2 Wahyu Wijaya Hadiwikarta,1 Nick Smisdom,1,2 Bart Wathiong,1,3 Marcel Ameloot,2 Inge Nelissen,1 Jef Hooyberghs1,3 1VITO, Flemish Institute for Technological Research, Mol, Belgium; 2Biomedical Research Institute, Hasselt University ...
Deville S, Hooyberghs J, Hadiwikarta WW, Nelissen I, Smisdom N, Wathiong B, Ameloot M   +6 more
core  

Progenitor cell trafficking in physiologic conditions and in myeloproliferative diseases: quantification of CD34+ cells by polymerase chain reaction. [PDF]

, 2005
BACKGROUND AND OBJECTIVES Previous studies using flow cytometry have shown that CD34+ cell trafficking is increased in patients with chronic idiopathic myelofibrosis. Few data exist on physiologic CD34 + cell trafficking and the quantification of very
Oppliger Leibundgut, Elisabeth, Brunold, Claudio, Schmid, Jean-Paul, Schroeder, Verena, Seiler, Christian, Marti, Dorothee, Zwicky, Caroline, Tobler, Andreas, Horn, Michael Peter   +8 more
core