Results 221 to 230 of about 275,058 (289)

Exploring a Flow Cytometry-Based CFU Assay for Functional Assessment of Human HSPCs: a Robust Alternative to Morphological Colony Evaluation. [PDF]

Stem Cell Rev Rep
Revenfeld ALS, Møller AMJ, Tylvad M, Bill M, Rosenberg CA, Møller BK.   +5 more
europepmc   +1 more source

The Role of SAMHD1 in Viral Resistance and Transduction Efficiency Challenges in Pediatric Hematological Malignancies: Mechanistic Insights and Clinical Perspectives

European Journal of Haematology, EarlyView.
SAMHD1 regulates intracellular dNTP pools, influencing lentiviral transduction, gene therapy efficiency, and disease progression in pediatric hematological malignancies. Integrated bioinformatics and targeted strategies, including CRISPR and pharmacological inhibition, highlight its therapeutic potential.
Waseem Alzamzami
wiley   +1 more source

Functional dissection of the gene regulatory mechanism underlying variation in blood CD34⁺ cell levels at 1p36.23/ENO1. [PDF]

Sci Rep
Ali Z, Cafaro C, Ekdahl L, Lamarca A, Lopez de Lapuente Portilla A, Nilsson B.   +5 more
europepmc   +1 more source

Whole Blood Transcriptomic Analysis of Sickle Cell Trait

European Journal of Haematology, EarlyView.
ABSTRACT Sickle cell trait (SCT) is the heterozygous carrier state for the HBB missense variant which causes sickle cell disease (SCD). SCT has been associated with increased risk of venous thromboembolism and chronic kidney disease as well as alterations in clinical laboratory parameters. To investigate differential gene expression in SCT, we used RNA
Mari Johnson, Yanwei Cai, Ana Gabriela Vasconcelos, Peter Orchard, Paul L. Auer, Guillaume Lettre, Jia Wen, Nora Franceschini, Charles Kooperberg, Wei Sun, Li Hsu, Laura M. Raffield, Alex P. Reiner   +12 more
wiley   +1 more source

Efficacy of Repeated Administration of Cultured Human CD34⁺ Cells Against Streptozotocin-Induced Diabetic Nephropathy in Rats. [PDF]

Cells
Ohtake T, Salybekov AA, Sato T, Okamura S, Yazawa M, Yano Y, Hassanpour M, Yanai M, Imagawa M, Asahara T, Kobayashi S.   +10 more
europepmc   +1 more source

Impact of Preanalytical Sample Preparation on the Recovery Rate of Cryopreserved Allogeneic Hematopoietic Stem Cells

European Journal of Haematology, EarlyView.
ABSTRACT Introduction Cryopreservation of peripheral‐blood‐derived hematopoietic stem and progenitor cells (PBSCs) has been used for decades, primarily for autologous transplantation. Now, in the era of new cellular therapies, the cryopreservation of allogeneic PBSCs may also become relevant.
Philipp Blüm, Christina Glas, Karen Bieback, Sabine Kayser, Harald Klüter, Patrick Wuchter   +5 more
wiley   +1 more source

Evaluation of peripheral blood stem cell collection in the Japan Marrow Donor Program (JMDP). [PDF]

Transfusion
Yamazaki R, Yakushijin K, Yoshihara S, Ikeda K, Ishida A, Kajiwara M, Kikuta A, Takagi N, Nagamura-Inoue T, Namba N, Haraguchi K, Fujimori Y, Fujiwara SI, Yamada-Fujiwara M, Okuyama Y, Tanosaki R, Ueda Y.   +16 more
europepmc   +1 more source

Adult granulosa cell tumours of the testis analogous to ovarian counterparts are exceptionally rare: analysis of a multicentric series and review of the literature

Histopathology, EarlyView.
Assessment of twenty testicular AGCTs with two different next‐generation sequencing (NGS) panels reveals differences with ovarian AGCTs, including absence of hotspot FOXL2 variants. Aims Testicular adult granulosa cell tumours (AGCTs) are rare and show several clinical–pathological differences with their ovarian counterparts.
Costantino Ricci, Dario de Biase, Thais Maloberti, Agnese Orsatti, Thomas M Ulbright, Muhammad T Idrees, Esther Oliva, Kristine Cornejo, João Lobo, Kvetoslava Michalova, Maria Rosaria Raspollini, Sean R Williamson, Geert JLH van Leenders, Chia‐Sui Kao, Fiona Maclean, Ankur R Sangoi, Adeboye O Osunkoya, Michelangelo Fiorentino, Antonio De Leo, Giovanni Tallini, Andres Martin Acosta   +20 more
wiley   +1 more source