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CD34+ or CD34−: Does it Really Matter?
Blood, 1999T HE CELL SURFACE glycoprotein CD34 has been the focus of intense interest ever since its discovery on a small fraction of human bone marrow cells.[1][1] The CD34+population appears responsible for most, if not all, of the hematopoietic activity in bone marrow, including colony formation in short-
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CD34+ Leukemic Cells Assessed by Different CD:34 Monoclonal Antibodies
Leukemia & Lymphoma, 1995CD34 monoclonal antibodies (McAbs) are widely used to identify and isolate hemopoietic progenitors and to classify acute and chronic leukemias. We assessed the reactivity of 17 CD34 McAbs from the 5th International Workshop on Leukocyte Differentiation Antigens with a variety of cells types: normal bone marrow hemopoietic progenitors, 10 AML, 6 ALL, 11
LANZA, Francesco +6 more
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Transduction of CD34+ and CD34−/lin− hemopoietic progenitors by lentivirus vectors
Cytotherapy, 1999While hemopoietic stem cells have been thought to reside predominantly in the CD34(+) population, recent data suggests that repopulating cells may, in fact, also reside in the lin(-)/CD34(-) population. Transduction of both these populations by murine retroviral vectors is limited by quiescence of hemopoietic stem cells.We therefore sought to transduce
K, Moriwaki +4 more
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CD34 measurement: setting standards
Cytotherapy, 2014Flow cytometric analysis has provided the hematopoietic transplant community with a powerful and rapid tool for assessing the engraftment potential of stem cell products. As described by Preti et al. [1] in this issue of the Journal, this was made possible by the identification of the CD34 antigen, and the commercial availability of fluorescently ...
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Molecular cloning of feline CD34
Veterinary Immunology and Immunopathology, 2003In humans, baboons, dogs and mice CD34 is a cell surface molecule that is expressed on primitive hematopoietic cells and in all these species CD34 positive cells can be used to effect long-term haematopoietic reconstitution. CD34 positive haematopoietic cells therefore provide a convenient and relatively small cell population to target when attempting ...
Yogalingam, G., Anson, D.
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CD34 expression in desmoplastic melanoma
Journal of Cutaneous Pathology, 2001Background: Primary and metastatic malignant melanoma can simulate various soft tissue tumors, including dermatofibrosarcoma protuberans (DFSP). Expression of CD34, a marker characteristic of DFSP, as well as other spindle cell tumors, has not been previously documented in malignant melanoma.Methods: We present here an unusual case of metastatic ...
M P, Hoang +4 more
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CD34-Reactive Myxoid Dermal Dendrocytoma
The American Journal of Dermatopathology, 2002Normal skin is composed in part of cells that express CD34. These include periadnexal spindle cells, vascular endothelial cells, and interstitial dendritic cells. We report on a tumor composed mainly of CD34-reactive spindle cells. A 66-year-old Japanese woman presented with a skin-colored, dome-shaped, cutaneous papule on her left palm that was 7 mm ...
Chika, Ohata, Kunimitsu, Kawahara
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Superficial CD34-Positive Fibroblastic Tumor
Surgical Pathology ClinicsSuperficial CD34-positive fibroblastic tumor is a mesenchymal neoplasm of "intermediate malignancy" recently included in the fifth edition of the World Health Organization classification of soft tissue and bone tumors. In this review, we summarize the current knowledge on this rare entity with a special focus on its clinicopathological features ...
Raul, Perret, Isabelle, Hostein
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