Results 61 to 70 of about 207,267 (296)

Study of Peripheral Mononuclear Cells and CD34 Levels as a Predictive Marker for Initiating Apheresis in Autologous Stem Cell Transplant

International Journal of Hematology-Oncology and Stem Cell Research, 2021
Background: Autologous HCT in multiple myeloma is done as upfront treatment in newly diagnosed transplant eligible patients after induction chemotherapy.
Kiran PK, Vinu Sarathy P, Srinivas BJ, Girish V Badarkhe, Rajesh Kumar KS, Thianeshwaran S, Nitin Bayas, Suhail Syeed Mufti, Hrishi V, Radheshyam Naik   +9 more
doaj   +1 more source

Optimization of B Cell Responses in Human Immune System Mice Through Organoid Based Screening

Advanced Science, EarlyView.
Human immune system (HIS) mice show limited B cell responses to immunization. Using HIS mouse spleen organoids, this study identifies cytokine combinations and innate immune signals that drive human B cell expansion, differentiation, and class‐switch. Applying these signals in vivo through temporal separation enables antigen‐specific IgG responses and ...
Haiqiao Sun, He Li, Xu Zhu, Zijian Zhang, Deshan Ren, Shuai Ding, Yan Li   +6 more
wiley   +1 more source

Allogeneic human umbilical cord Wharton’s jelly stem cells increase several-fold the expansion of human cord blood CD34+ cells both in vitro and in vivo

Stem Cell Research & Therapy, 2020
Background The transplantation of human umbilical cord blood (UCB) CD34+ cells has been successfully used to treat hematological disorders but one major limitation has been the low cell numbers available.
Hao Daniel Lin, Chui-Yee Fong, Arijit Biswas, Ariff Bongso   +3 more
doaj   +1 more source

Association between height and circulating CD34-positive cells taken into account for the influence of enhanced production among elderly Japanese men: a cross-sectional study

, 2019
Recent studies have revealed an inverse association between height and cardiovascular disease and that endothelial progenitor cells(CD34-positive cells) contribute to vascular maintenance, which is associated with cardiovascular disease. However,evidence
Noguchi, Yuko, Kawashiri, Shin-Ya, Tamai, Mami, Maeda, Takahiro, Nagayoshi, Mako, Arima, Kazuhiko, Kiyoura, Kairi, Yamanashi, Hirotomo, Koyamatsu, Jun, Fukui, Shoichi, Shimizu, Yuji   +10 more
core   +1 more source

Endogenous Engineering Reprograms Extracellular Vesicles for Enhanced Therapeutic Function

Advanced Science, EarlyView.
This review explains how Extracellular vesicles‐producing cells can be endogenously engineered to load therapeutic proteins and nucleic acids. We summarize physiological and genetic strategies that harness native sorting pathways for selective cargo loading.
Jinghui Wang, Wenxuan Zhao, Xiaoming Hu, Yishu Wang, Peidong Yang, Diwei Zheng, Yugang Wang, Guanghui Ma, Min Shi, Wei Wei, Shuang Wang   +10 more
wiley   +1 more source

New Insights on Efficacy and Safety Autologous CD34+ Stem Cells for Refractory Angina: Systematic Review and Meta-analysis of Comparative Long- versus Short-term Therapy

Journal of Preventive, Diagnostic and Treatment Strategies in Medicine
BACKGROUND: Current studies suggest that refractory angina management remains suboptimal. On the other hand, CD34+ autologous stem cells have shown to be potential in improving coronary microcirculation and enhancing clinical effect.
Juan Alessandro Jeremis Maruli Nur Lele, Dewa Vighneshwara, Karlos Berlusconi Sihaloho, Derren David Christian Homenta Rampengan, Starry Homenta Rampengan, Gusti Ngurah Prana Jagannatha, Muhammad Iqhrammullah, Athaya Febriyanto Purnomo   +7 more
doaj   +1 more source

Cord blood-derived CD34+ hematopoietic cells with low mitochondrial mass are enriched in hematopoietic repopulating stem cell function

Haematologica, 2013
The homeostasis of the hematopoietic stem/progenitor cell pool relies on a fine-tuned balance between self-renewal, differentiation and proliferation. Recent studies have proposed that mitochondria regulate these processes.
Damia Romero-Moya, Clara Bueno, Rosa Montes, Oscar Navarro-Montero, Francisco J. Iborra, Luis Carlos López, Miguel Martin, Pablo Menendez   +7 more
doaj   +1 more source

Functional activity of murine CD34+and CD34− hematopoietic stem cell populations

Experimental Hematology, 1999
The transmembrane glycoprotein CD34 is expressed on human hematopoietic stem cells and committed progenitors in the bone marrow, and CD34-positive selection currently is used to isolate bone marrow repopulating cells in clinical transplantation protocols.
D S, Donnelly, D, Zelterman, S, Sharkis, D S, Krause   +3 more
openaire   +2 more sources

Hyperlipidemia Aggravates Alveolar Bone Loss via Periodontal Ligament Stem Cell Ferroptosis Through GSK3β Dependent Ubiquitin‐Mediated NRF2 Degradation

Advanced Science, EarlyView.
Lipid metabolic stress triggers ferroptosis in PDLSCs through the GSK3β/NRF2 pathway, thereby aggravating periodontal bone loss. Upregulated GSK3β promotes NRF2 ubiquitination and proteasomal degradation via β‐TrCP, suppressing NRF2 nuclear translocation and antioxidant target expression.
Yuxiao Zhang, Xiangyao Wang, Yaxin Wu, Liping Liu, Gaoshaer Nuerlan, Ahsawle Ozathaley, Xiaorui Zhang, Jinping Wang, Bowen Yang, Jing Mao, Yan Liu, Shiqiang Gong   +11 more
wiley   +1 more source

Human Umbilical Cord Blood–Derived CD34+Cells Can Be Used as a Prophylactic Agent for Experimental Heatstroke

Journal of Pharmacological Sciences, 2008
We attempted to assess the prophylactic effect of human umbilical cord blood–derived CD34+cells in experimental heatstroke. Anesthetized rats, 1 day before heat stress, were divided into 2 major groups and given CD34−cells (defined by 1 × 106human cord ...
Wei-Shou Hwang, Sheng-Hsien Chen, Cheng-Hsien Lin, Hsiu-Kang Chang, Wei-Chun Chen, Mao-Tsun Lin   +5 more
doaj   +1 more source