Results 71 to 80 of about 276,090 (288)

New Insights on Efficacy and Safety Autologous CD34+ Stem Cells for Refractory Angina: Systematic Review and Meta-analysis of Comparative Long- versus Short-term Therapy

Journal of Preventive, Diagnostic and Treatment Strategies in Medicine
BACKGROUND: Current studies suggest that refractory angina management remains suboptimal. On the other hand, CD34+ autologous stem cells have shown to be potential in improving coronary microcirculation and enhancing clinical effect.
Juan Alessandro Jeremis Maruli Nur Lele, Dewa Vighneshwara, Karlos Berlusconi Sihaloho, Derren David Christian Homenta Rampengan, Starry Homenta Rampengan, Gusti Ngurah Prana Jagannatha, Muhammad Iqhrammullah, Athaya Febriyanto Purnomo   +7 more
doaj   +1 more source

Human Umbilical Cord Blood–Derived CD34+Cells Can Be Used as a Prophylactic Agent for Experimental Heatstroke

Journal of Pharmacological Sciences, 2008
We attempted to assess the prophylactic effect of human umbilical cord blood–derived CD34+cells in experimental heatstroke. Anesthetized rats, 1 day before heat stress, were divided into 2 major groups and given CD34−cells (defined by 1 × 106human cord ...
Wei-Shou Hwang, Sheng-Hsien Chen, Cheng-Hsien Lin, Hsiu-Kang Chang, Wei-Chun Chen, Mao-Tsun Lin   +5 more
doaj   +1 more source

Notch signaling during human T cell development [PDF]

, 2012
Notch signaling is critical during multiple stages of T cell development in both mouse and human. Evidence has emerged in recent years that this pathway might regulate T-lineage differentiation differently between both species.
A Galy, A Krueger, A Sambandam, A Wilson, A Wolfer, AC Jaleco, AI Garbe, AP Weng, B Blom, B Reizis, B Vandekerckhove, BN Weber, C Benne, CC Tydell, CN Ting, D Hockemeyer, D Hockemeyer, E Robey, EM Six, ES David-Fung, F Klein, F Radtke, F Radtke, F Timmermans, F Weerkamp, F Weerkamp, G Awong, H Hirata, H Neves, H Wang, HT Petrie, HY Kueh, I Hoebeke, I Maillard, I Maillard, I Walle Van de, I Walle Van de, J Buer, J Gotter, J Plum, J Shi, JS Yuan, K Heinzel, K Hozumi, K Li, K Maki, K Tanigaki, L Li, M Ciofani, M Ciofani, M Ciofani, M Garcia-Peydro, M Ghisi, M Magri, M Smedt De, M Smedt De, M Smedt De, M Smedt De, MA Yui, MD Green, ML Joachims, N Lefort, P Beatus, P Doerfler, P Li, QL Hao, QL Hao, R Haddad, RN Motte-Mohs La, S Coppernolle Van, S Doulatov, S Gonzalez-Garcia, S Suliman, S Verbeek, SK Durum, SK Ye, SM Lehar, SY Lee, T Hosoya, T Ikawa, T Ikawa, T Kreslavsky, T Kreslavsky, T Palomero, T Taghon, T Taghon, T Taghon, T Taghon, T Taghon, T Taghon, TB Feyerabend, TM Schmitt, TN Taghon, W Dontje, WA Dik, Y Wu, YR Carrasco, Z Galic   +97 more
core   +2 more sources

A Biomarker‐Driven Ovary–Endometrium Organ‐on‐a‐Chip Mimicking 3D Multicellular Complexity and Menstrual Cyclicity for Predicting Reproductive Toxicity

Advanced Science, EarlyView.
We present a dual‐organ, biomarker‐integrated ovaryendometrium organ‐on‐a‐chip that recapitulates 3D tissue complexity, menstrual cycle dynamics, and hormonal crosstalk. This platform enables real‐time, cell‐typespecific fluorescent readouts of reproductive toxicity using ANGPTL4 and SERPINB2 as early‐response reporters.
Soo‐Rim Kim, Eun‐kyung Min, Choon‐Mi Lee, Chan Hum Park, Byung‐Chul Oh, YunJae Jung, In‐Sun Hong   +6 more
wiley   +1 more source

Cord blood-derived CD34+ hematopoietic cells with low mitochondrial mass are enriched in hematopoietic repopulating stem cell function

Haematologica, 2013
The homeostasis of the hematopoietic stem/progenitor cell pool relies on a fine-tuned balance between self-renewal, differentiation and proliferation. Recent studies have proposed that mitochondria regulate these processes.
Damia Romero-Moya, Clara Bueno, Rosa Montes, Oscar Navarro-Montero, Francisco J. Iborra, Luis Carlos López, Miguel Martin, Pablo Menendez   +7 more
doaj   +1 more source

Epigenetic dysregulation in chronic myeloid leukaemia: A myriad of mechanisms and therapeutic options [PDF]

, 2018
The onset of global epigenetic changes in chromatin that drive tumor proliferation and heterogeneity is a hallmark of many forms cancer. Identifying the epigenetic mechanisms that govern these changes and developing therapeutic approaches to modulate ...
Koschmieder, Steffen, Vetrie, David
core   +1 more source

DCAF13 Safeguards Hematopoietic Stem Cells via RRS1‐Regulated Ribosome Biogenesis

Advanced Science, EarlyView.
This study establishes DCAF13 as an essential regulator for hematopoietic stem cell (HSC) function. Its deletion in mice causes lethal pancytopenia and HSC depletion. Mechanistically, DCAF13 interacts with RRS1 and mediates its non‐degradative K27‐linked ubiquitination, thereby stabilizing RRS1 to maintain ribosome biogenesis and protein translation ...
Mengke Li, Yuxin Wu, Shuai Zhou, Peipei Tang, Jiaming Wei, Ling Liu, Zhenyi Wang, Deyang Shi, Shengnan Yuan, Qingyu Zhang, Shihui Wang, Qing Zhang, Huan Zhao, Rui Zhang, Yingying Wang, Shiwei Yang, Xiangli Chen, Xiaojing Shi, Guangzhi Liu, Yuwei Zhang, Jinming Li, Xu Dong Zhang, Rick F Thorne, Dongping Wei, Zumin Zhu, Song Chen   +25 more
wiley   +1 more source

Consumptive reduction following increased production of CD34-positive cells and carotid intima-media thickness in non-hypertensive elderly Japanese men

Cogent Medicine, 2019
Background: Increase in the number of circulating CD34-positive cells has been shown to have a protective effect against atherosclerosis, owing to an inverse association with the disease.
Yuji Shimizu, Hirotomo Yamanashi, Yuko Noguchi, Jun Koyamatsu, Kairi Kiyoura, Shin-Ya Kawashiri, Takahiro Maeda   +6 more
doaj   +1 more source

Time‐Controlled Refrigerated Stem Cell Therapy Mitigates Scleroderma Fibrosis via Modulation of Mitochondrial Autophagy and Gut Metabolism

Advanced Science, EarlyView.
This study established an RT‐MSCs‐based therapeutic approach for scleroderma in mice. RT‐MSCs attenuated fibrosis by regulating mitochondrial autophagy and restored gut microbiota homeostasis. Metabolomic analyses confirmed recovery of key metabolites, and RT‐MSCs demonstrated favorable lesion targeting and safety profiles.
Xue Xia, Chenfei Kong, Xiaoming Zhao, Naixu Shi, Jinlan Jiang, Ping Li   +5 more
wiley   +1 more source

Cross talk with hematopoietic cells regulates the endothelial progenitor cell differentiation of CD34 positive cells.

PLoS ONE, 2014
IntroductionDespite the crucial role of endothelial progenitor cells (EPCs) in vascular regeneration, the specific interactions between EPCs and hematopoietic cells remain unclear.MethodsIn EPC colony forming assays, we first demonstrated that the ...
Sang-Mo Kwon, Jun-Hee Lee, Sang-Hun Lee, Seok-Yun Jung, Da-Yeon Kim, Song-Hwa Kang, So-Young Yoo, Jong-Kyu Hong, Ji-Hye Park, Jung-Hee Kim, Sung-Wook Kim, Yeon-Ju Kim, Sun-Jin Lee, Hwi-Gon Kim, Takayuki Asahara   +14 more
doaj   +1 more source