Results 71 to 80 of about 207,267 (296)

Single cell and lineage tracing studies reveal the impact of CD34+ cells on myocardial fibrosis during heart failure

Stem Cell Research & Therapy, 2023
Background CD34+ cells have been used to treat the patients with heart failure, but the outcome is variable. It is of great significance to scrutinize the fate and the mechanism of CD34+ cell differentiation in vivo during heart failure and explore its ...
Luping Du, Xiaotong Sun, Hui Gong, Ting Wang, Liujun Jiang, Chengchen Huang, Xiaodong Xu, Zhoubin Li, Hongfei Xu, Liang Ma, Weidong Li, Ting Chen, Qingbo Xu   +12 more
doaj   +1 more source

Boosting Sensory Nerve‐to‐Bone Interactions Enhances Hedgehog Mediated Calvarial Bone Repair

Advanced Science, EarlyView.
Boosting sensory nerve activity via TrkA agonism strongly accelerates calvarial bone repair in adult mice. Furthermore, single‐cell RNA sequencing and neuron–bone interactome analyses identify these sensory neurons as a direct neural source of Hedgehog pathway ligands. Consequently, these ligands drive osteoblast differentiation of skeletal progenitors,
Zhao Li, Xin Xing, Beicheng Du, Myles Zhou, Austin Z. Chen, Mary Archer, Chunbao Rao, Manyu Zhu, Masnsen Cherief, Aaron W. James   +9 more
wiley   +1 more source

Consumptive reduction following increased production of CD34-positive cells and carotid intima-media thickness in non-hypertensive elderly Japanese men

Cogent Medicine, 2019
Background: Increase in the number of circulating CD34-positive cells has been shown to have a protective effect against atherosclerosis, owing to an inverse association with the disease.
Yuji Shimizu, Hirotomo Yamanashi, Yuko Noguchi, Jun Koyamatsu, Kairi Kiyoura, Shin-Ya Kawashiri, Takahiro Maeda   +6 more
doaj   +1 more source

Absence of a CD34− hematopoietic precursor population in recipients of CD34+ stem cell transplantation [PDF]

Bone Marrow Transplantation, 2001
The purified CD34(+) cell fraction has been used for hematopoietic stem cell transplantation since they were demonstrated to have long-term reconstituting ability. Therefore, the potential effects of CD34(-) stem cells on the clinical course have been a major concern in recipients of CD34(+)-selected transplantation. To address this concern, we used an
S, Kato, K, Ando, Y, Nakamura, Y, Muguruma, T, Sato, H, Yabe, M, Yabe, K, Hattori, Y, Yasuda, T, Hotta   +9 more
openaire   +2 more sources

Expansão ex vivo de células-tronco/progenitoras hematopoiéticas de sangue de cordão umbilical e placentário [PDF]

, 2014
Tese (doutorado) - Universidade Federal de Santa Catarina, Centro de Ciências da Saúde, Programa de Pós-Graduação em Farmácia, Florianópolis, 2014.As Células-tronco progenitoras hematopoiéticas (CTPHs) do sangue de cordão umbilical e placentário (SCUP ...
Benedetti, Aloisio Luiz
core  

Characterization of CD34-deficient myofibroblastomas of the breast.

, 2017
Mammary myofibroblastoma is a benign spindle cell tumor that can show variable morphologic patterns and lines of differentiation. Diffuse and strong immunohistochemical expression of CD34 is a characteristic of myofibroblastoma and greatly aids in ...
Subramaniyam, Shivakumar, Yi-Fang Liu, Mosquera, Juan Miguel, Juan Miguel Mosquera, Paula S. Ginter, Shin, Sandra J, Jaclyn Croyle, Ginter, Paula S, Timothy M. D'Alfonso, Shivakumar Subramaniyam, Liu, Yi-Fang, Mark A. Rubin, Rubin, Mark Andrew, D'Alfonso, Timothy M, Croyle, Jaclyn, Sandra J. Shin   +15 more
core   +1 more source

High‐Performance Prevascularized SHED‐Laden rGO@Hydrogel Achieves Optimized Diabetic Bone Defect Repair

Advanced Science, EarlyView.
A high‐performance 3D scaffold integrating rGO and SHEDs is developed to overcome impaired healing in diabetic bone defects. By driving extracellular matrix remodeling, rGO creates a pro‐angiogenic niche that significantly accelerates in vitro vascular network formation.
Can Zhang, Yiyuan Kang, Shulin Lai, Chunyi Wang, Guixin He, Kehui Jian, Suhan Yin, Xiner Tan, Xinru Zhou, Wenjing Liu, Fujian Zhao, Jia Liu, Longquan Shao   +12 more
wiley   +1 more source

Cross talk with hematopoietic cells regulates the endothelial progenitor cell differentiation of CD34 positive cells.

PLoS ONE, 2014
IntroductionDespite the crucial role of endothelial progenitor cells (EPCs) in vascular regeneration, the specific interactions between EPCs and hematopoietic cells remain unclear.MethodsIn EPC colony forming assays, we first demonstrated that the ...
Sang-Mo Kwon, Jun-Hee Lee, Sang-Hun Lee, Seok-Yun Jung, Da-Yeon Kim, Song-Hwa Kang, So-Young Yoo, Jong-Kyu Hong, Ji-Hye Park, Jung-Hee Kim, Sung-Wook Kim, Yeon-Ju Kim, Sun-Jin Lee, Hwi-Gon Kim, Takayuki Asahara   +14 more
doaj   +1 more source

Proliferation and differentiation of myelodysplastic CD34+ cells: phenotypic subpopulations of marrow CD34+ cells [PDF]

Blood, 1995
In a search for a mechanism to explain the impaired growth of progenitor cells in patients with myelodysplastic syndromes (MDS), marrow CD34+ cells were purified up to 94.9% +/- 4.2% for normal individuals and 88.1% +/- 17.6% for MDS patients, using monoclonal antibodies and immunomagnetic microspheres (MDS CD34+ cells).
K, Sawada, N, Sato, A, Notoya, T, Tarumi, S, Hirayama, H, Takano, K, Koizumi, T, Yasukouchi, M, Yamaguchi, T, Koike   +9 more
openaire   +2 more sources

PIEZO1 is Required for Acute Myeloid Leukemia Progression and Leukemia Stem Cell Maintenance via HIF1A‐SLC7A11 Axis‐Mediated Ferroptosis Defense

Advanced Science, EarlyView.
This study identifies the mechanosensor PIEZO1 as a key factor in promoting acute myeloid leukemia progression and uncovers a ferroptosis defense system mediated by PIEZO1‐HIF1A‐SLC7A11 axis that is essential for leukemia stem cell maintenance. This ferroptotic defense system may represent a unique vulnerability for leukemia stem cells, providing a ...
Tiantian Zhang, Ziyan Cao, Kexin Gao, Shuxin Yao, Yanbing Zheng, Manman Cui, Rong Yin, Guoqiang Han, Jin Hu, Chengyi Wang, Haojian Zhang   +10 more
wiley   +1 more source