Results 41 to 50 of about 220,756 (241)

Characterization of DLK1(PREF1)+/CD34+ cells in vascular stroma of human white adipose tissue

Stem Cell Research, 2015
Sorting of native (unpermeabilized) SVF-cells from human subcutaneous (s)WAT for cell surface staining (cs) of DLK1 and CD34 identified three main populations: ~10% stained cs-DLK1+/cs-CD34−, ~20% cs-DLK1+/cs-CD34+dim and ~45% cs-DLK1−/cs-CD34+.
Marit E. Zwierzina, Asim Ejaz, Mario Bitsche, Michael J.F. Blumer, Maria C. Mitterberger, Monika Mattesich, Arno Amann, Andreas Kaiser, Elisabeth J. Pechriggl, Susanne Hörl, Ursula Rostek, Gerhard Pierer, Helga Fritsch, Werner Zwerschke   +13 more
doaj   +1 more source

GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma

FEBS Open Bio, EarlyView.
GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain, Elise Buret, Le Hoang Thanh Nguyen, Marion Cocheteux, Nicolas Touya, Mélanie Dhayer, Romain Dubois, Frank Lafont, Sebastien Janel, Patrice Maboudou, Steve Lancel, Philippe Marchetti   +11 more
wiley   +1 more source

Exploring hematopoietic stem cell population in human milk and its benefits for infants: A scoping review

Asian Pacific Journal of Reproduction
Objective: To comprehensively explore hematopoietic stem cells (HSCs) in human milk, understanding their molecular markers, isolation methods, benefits for infants, and potential medical applications.
Ghaniyyatul Khudri, Dewi Sukmawati
doaj   +1 more source

Ex vivo expansion of hematopoietic cells today [PDF]

Scripta Medica, 2011
Ex vivo expansion (amplification) of hematopoietic stem and progenitors cells is a concept aimed to resolve the problem of insufficient number of cells for engraftment and/or to accelerate hematopoietic reconstitution after transplantation.
Ivanović Zoran
doaj  

GDNF‐Enriched Small Extracellular Vesicle‐Loaded ROS‐Scavenging Hydrogel Promotes Neural Regeneration After Spinal Cord Injury

Advanced Healthcare Materials, EarlyView.
A glial cell line‐derived neurotrophic factor (GDNF)‐enriched small extracellular vesicle‐loaded reactive oxygen species (ROS)‐scavenging hydrogel integrates sustained neurotrophic delivery with local modulation of oxidative and inflammatory stress after spinal cord injury. The composite hydrogel improves local vesicle retention, protects neural tissue,
Xingyu Zhu, Zhong Liu, Kewei Li, Yuhong Fan, Kangjia Yang, Xiaopeng Sun, Hang Shi, Lixuan Sun, Yang Lou, Min Wang, Peipei Wu, Hui Qian, Qiang Fu, Hua Ding   +13 more
wiley   +1 more source

Efficiency and safety of haematopoietic stem cell collection in healthy donors

Zhongguo shuxue zazhi
[Objective] To explore the key factors affecting the efficiency and safety of hematopoietic stem cell apheresis. [Methods] The clinical data of 59 healthy donors who underwent allogeneic hematopoietic stem cell donation in the First Affiliated Hospital ...
HE Rui, ZHU Bangqiang, WEN Huiqin, WANG Haijing, BIAN Maohong, DIAO Yujie   +5 more
doaj   +1 more source

Impaired bone marrow homing of cytokine-activated CD34⁺ cells in the NOD/SCID model [PDF]

, 2004
The reduced engraftment potential of hematopoietic stem/progenitor cells (HSPCs) after exposure to cytokines may be related to the impaired homing ability of actively cycling cells. We tested this hypothesis by quantifying the short-term horning of human
Pizzey, AR, Fahey, A, Ings, SJ, Yong, KL, Blundell, MP, Thrasher, AJ, Linch, DC, Ahmed, F, Ye, HT   +8 more
core  

Compensatory Mitophagy via NEDD4/HIF‐1α/BNIP3 Pathway Restrains EndMT and Renal Allograft Interstitial Fibrosis Induced by TNFα

Advanced Science, EarlyView.
The role of TNFα in the process of renal allograft interstitial fibrosis is complex and multifaceted. As it can promote renal allograft interstitial fibrosis by inducing mitochondrial dysfunction and EndMT, and also mediating compensatory mitophagy through the NEDD4–HIF‐1α–BNIP3 pathway, which clears damaged mitochondria and inhibits EndMT, thereby ...
Dengyuan Feng, Qinghuan Shen, Junqi Zhang, Jiawen Liu, Zeping Gui, Zijie Wang, Qianguang Han, Shuang Fei, Hao Chen, Li Sun, Jun Tao, Zhijian Han, Xiaobing Ju, Min Gu, Jianjian Zhang, Ruoyun Tan   +15 more
wiley   +1 more source

CD34 Is a Ligand for Vascular Selectins on Human Hematopoietic Stem/Progenitor Cells

, 2015
The cell surface glycoprotein CD34 is widely recognized as a marker of hematopoietic stem/progenitor cells (HSPCs), but its physiological role on HSPCs remains elusive. Although CD34 is well recognized for mediating homing of L-selectin+ naïve T cells to
Abu Samra, Dina Bashir Kamil
core   +1 more source

Modulation of miR‐23b Wnt/β‐catenin Axis Strengthens Endothelial Barrier Properties

Advanced Science, EarlyView.
Early blood‐brain barrier (BBB) disruption contributes to stroke and CNS disease pathology. miR‐23b was identified as a regulator of BBB integrity in brain endothelial cells. Inhibition of miR‐23b enhanced barrier‐associated properties, promoted repair‐related signaling, and reduced BBB leakage in experimental stroke models, supporting further ...
Victor Anthony Martinez, Rose E. Presby, Sara Nakanishi, Pallavi Gaur, Ugur Akcan, Johannes Daugaard Krog, Iben Daugaard Krog, Lipi Das, David S. Johnson, Danny Jamoul, Douglas Jury, Brian Lawson, Jacob Körbelin, Lewis M. Brown, Vilas Menon, Dritan Agalliu, Irene Munk Pedersen   +16 more
wiley   +1 more source