Results 21 to 30 of about 276,090 (288)

Gammaretrovirus-mediated correction of SCID-X1 is associated with skewed vector integration site distribution in vivo [PDF]

, 2007
We treated 10 children with X-linked SCID (SCID-X1) using gammaretrovirus-mediated gene transfer. Those with sufficient follow-up were found to have recovered substantial immunity in the absence of any serious adverse events up to 5 years after treatment.
Kerstin Schwarzwaelder, Steven J. Howe, Manfred Schmidt, Martijn H. Brugman, Annette Deichmann, Hanno Glimm, Sonja Schmidt, Claudia Prinz, Manuela Wissler, Douglas J.S. King, Fang Zhang, Kathryn L. Parsley, Kimberly C. Gilmour, Joanna Sinclair, Jinhua Bayford, Rachel Peraj, Karin Pike-Overzet, Frank J.T. Staal, Dick de Ridder, Christine Kinnon, Ulrich Abel, Gerard Wagemaker, H. Bobby Gaspar, Adrian J. Thrasher, Christof von Kalle, Cavazzana-Calvo, Gaspar, Hacein-Bey-Abina, Aiuti, Aiuti, Gaspar, Ott, Hacein-Bey-Abina, Li, Kustikova, Modlich, Montini, Mitchell, Schröder, Wu, Bushman, Schmidt, Schmidt, Hematti, Laufs, Suzuki, Bartholomew, Recchia, Calmels, Hoeben, Palmer, Xu, Dik, Ge   +53 more
core   +2 more sources

Extraction of totally impacted lower third molar with CGF (concentrated growth factors) application into a post-extraction bone defect – a case report

Journal of Education, Health and Sport, 2019
Concentrated Growth Factors (CGF) are obtained after blood collecting and its centrifuging. As an autogenic material it gains an advantage over xenogeneic materials used in regenerative procedures.
Adrian Gnatek, Anna Janas-Naze, Piotr Osica, Damianc Chybicki   +3 more
doaj   +1 more source

Omacetaxine may have a role in chronic myeloid leukaemia eradication through downregulation of Mcl-1 and induction of apoptosis in stem/progenitor cells [PDF]

, 2011
Chronic myeloid leukaemia (CML) is maintained by a rare population of tyrosine kinase inhibitor (TKI)-insensitive malignant stem cells. Our long-term aim is to find a BcrAbl-independent drug that can be combined with a TKI to improve overall disease ...
A Quintas-Cardama, A Quintas-Cardama, A Quintas-Cardama, AJ Tipping, AJ Tipping, B Zhang, C Akgul, C Bellodi, G Gurel, H de Lavallade, H Konig, HG Jorgensen, HM Kantarjian, J Kuroda, KJ Aichberger, L Legros, M Copland, M Copland, NB Heaney, R Chen, R Tang, RG Powell, RM Stone, S Chu, SM Graham, SV Sharma, T Kobayashi, Y Chen   +27 more
core   +1 more source

Stem Cell Antigen CD34 In Native And Engineered Form Alter Its Binding Ability To Stromal Cells And Ligands: A Classical Example Of Clinical Benefits Of Therapeutic Genetic Engineering Of Stem Cells In Transplantation [PDF]

, 2010
CD34 is a highly glycosylated surface-expressed sialomucin and, because it is present on hematopoietic stem cells (HSCs), has demonstrated immense clinical utility in their enumeration in aphaeresis products, immunoaffinity purification for ...
Gurudutta Gangenahalli, Neeraj Kumar Satija, Pallavi Gupta, Rajendra Prasad Tripathi, Vimal Kumar Singh, Yogesh Kumar Verma   +5 more
core   +2 more sources

Monoclonal antibodies against human CD34 antigens do not cross-react with ovine umbilical cord blood cells [PDF]

, 2010
CD34 is a cell surface glycoprotein expressed by hematopoietic progenitors and endothelial cells. It is widely used in the clinic for isolation of human hematopoietic stem cells.
Antuofermo, Elisabetta, Bonelli, Piero, Dattena, Maria, Manetti, Roberto, Nicolussi, Paola   +4 more
core   +3 more sources

CD34⁺/M-cadherin⁺ bone marrow progenitor cells promote arteriogenesis in ischemic hindlimbs of ApoE⁻/⁻ mice. [PDF]

PLoS ONE, 2011
BACKGROUND: Cell-based therapy shows promise in treating peripheral arterial disease (PAD); however, the optimal cell type and long-term efficacy are unknown.
Toya Terry, Zhiqiang Chen, Richard A F Dixon, Peter Vanderslice, Pierre Zoldhelyi, James T Willerson, Qi Liu   +6 more
doaj   +1 more source

Intravitreal Administration of Human Bone Marrow CD34+ Stem Cells in a Murine Model of Retinal Degeneration. [PDF]

, 2016
PurposeIntravitreal murine lineage-negative bone marrow (BM) hematopoietic cells slow down retinal degeneration. Because human BM CD34+ hematopoietic cells are not precisely comparable to murine cells, this study examined the effect of intravitreal human
Annett, Geralyn, Cary, Whitney, Moisseiev, Elad, Motta, Monica, Murphy, Christopher J, Nolta, Jan A, Oltjen, Sharon, Park, Susanna S, Smit-McBride, Zeljka, Zawadzki, Robert J, Zhang, Pengfei   +10 more
core   +2 more sources

Local Renin-Angiotensin System in Normal Hematopoietic and Multiple Myeloma-Related Progenitor Cells

Turkish Journal of Hematology, 2014
OBJECTIVE: The prominent functions of the local renin-angiotensin system (RAS) in primitive hematopoiesis further support the hypothesis that local autocrine bone marrow RAS could also be active in neoplastic hematopoiesis.
Burak Uz, Suzin Çatal Tatonyan, Müge Sayitoğlu, Yücel Erbilgin, Özden Hatırnaz, Salih Aksu, Yahya Büyükaşık, Nilgün Sayınalp, Hakan Göker, Osman İ. Özcebe, Uğur Özbek, İbrahim C. Haznedaroğlu   +11 more
doaj   +1 more source

Short-term pretreatment with a dual 5α-reductase inhibitor before bipolar transurethral resection of the prostate (b-turp): evaluation of prostate vascularity and decreased surgical blood loss in large prostates [PDF]

, 2015
Objective: To investigate if short-term treatment with dutasteride (8 weeks) before bipolar transurethral resection of the prostate (B-TURP) can reduce intraoperative bleeding, as dutasteride a dual 5α-reductase inhibitor (5-ARI) blocks the conversion of
Amory, Berry, Boccon-Gibod, Boyle, Carlin, De Berardinis, Delakas, Frye, Hahn, Issa, Kravchick, Ku, Lekas, Madersbacher, Marberger, Marks, Martov, Naslund, Oelke, Pareek, Pareek, Pastore, Puchner, Rittmaster, Roehrborn, Roehrborn, Roehrborn, Toi, Zaitsu   +28 more
core   +1 more source

Human umbilical cord blood-borne fibroblasts contain marrow niche precursors that form a bone/marrow organoid in vivo [PDF]

, 2017
Human umbilical cord blood (CB) has attracted much attention as a reservoir for functional hematopoietic stem and progenitor cells, and, recently, as a source of blood-borne fibroblasts (CB-BFs). Previously, we demonstrated that bone marrow stromal cell (
Biondi, Andrea, Corsi, Alessandro, Donsante, Samantha, Pievani, Alice, Rambaldi, Benedetta, Remoli, Cristina, Riminucci, Mara, Robey, Pamela G., Sacchetti, Benedetto, Scagliotti, Valeria, Serafini, Marta, Vergani, Patrizia   +11 more
core   +2 more sources