Transplantation of Immortalized CD34+ and CD34- Adipose-Derived Stem Cells Improve Cardiac Function and Mitigate Systemic Pro-Inflammatory Responses. [PDF]
PLoS ONE, 2016 Adipose-derived stem cells (ADSCs) have the potential to differentiate into various cell lineages and they are easily obtainable from patients, which makes them a promising candidate for cell therapy. However, a drawback is their limited life span during
Jong-Ho Kim +7 more
doaj +1 more source
Sirt1 expression is associated with CD31 expression in blood cells from patients with chronic obstructive pulmonary disease [PDF]
, 2016 Background: Cigarette smoke induced oxidative stress has been shown to reduce silent information regulator 1 (Sirt1) levels in lung tissue from smokers and patients with COPD patients.
Akai, Masaya +11 more
core +2 more sources
The antiproliferative activity of kinase inhibitors in chronic myeloid leukemia cells is mediated by FOXO transcription factors [PDF]
, 2014 Chronic myeloid leukemia (CML) is initiated and maintained by the tyrosine kinase BCR-ABL which activates a number of signal transduction pathways, including PI3K/AKT signaling and consequently inactivates FOXO transcription factors.
Bhatia +38 more
core +2 more sources
Journal of Education, Health and Sport, 2018 Concentrated growth factors are one of platelet-rich plasma preparations (PPP), specially prepared in medical centrifuges. Due to high concentration of blood platelets, which reveal different sorts of growth factors, CGF stimulates wound healing, reduces
Adrian Gnatek +2 more
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The effects of bone marrow stem and progenitor cell seeding on urinary bladder tissue regeneration
Scientific Reports, 2021 Complications associated with urinary bladder augmentation provide the motivation to delineate alternative bladder tissue regenerative engineering strategies.
Matthew I. Bury +8 more
doaj +1 more source
Modeling Anti-HIV-1 HSPC-Based Gene Therapy in Humanized Mice Previously Infected with HIV-1. [PDF]
, 2018 Investigations of anti-HIV-1 human hematopoietic stem/progenitor cell (HSPC)-based gene therapy have been performed by HIV-1 challenge after the engraftment of gene-modified HSPCs in humanized mouse models.
An, Dong Sung +13 more
core +2 more sources
Zagazig Journal of Pharmaceutical Sciences, 2013 Various studies had underlined the important role of bone marrow-derived endothelial progenitor cells (EPCS) in vasculogenesis and angiogenesis of ischemic tissue, but only a few studies had concentrated on the role of low doses of ionizing gamma ...
Hoda Mohammed +3 more
doaj +1 more source
Targeting quiescent leukemic stem cells using second generation autophagy inhibitors [PDF]
, 2019 In chronic myeloid leukemia (CML), tyrosine kinase inhibitor (TKI) treatment induces autophagy that promotes survival and TKI-resistance in leukemic stem cells (LSCs).
A Hamilton +42 more
core +2 more sources
Inflammatory Responses and Barrier Function of Endothelial Cells Derived from Human Induced Pluripotent Stem Cells [PDF]
, 2018 Several studies have reported endothelial cell (EC) derivation from human induced pluripotent stem cells (hiPSCs). However, few have explored their functional properties in depth with respect to line-to-line and batch-to-batch variability and how they ...
Freund, Christian +6 more
core +7 more sources
Human CD34+ progenitor cells freshly isolated from umbilical cord blood attenuate inflammatory lung injury following LPS challenge. [PDF]
PLoS ONE, 2014 Adult stem cell-based therapy is a promising novel approach for treatment of acute lung injury. Here we investigated the therapeutic potential of freshly isolated human umbilical cord blood CD34(+) progenitor cells (fCB-CD34(+) cells) in a mouse model of
Xiaojia Huang +6 more
doaj +1 more source