Results 11 to 20 of about 220,756 (241)

Engineering IL-4 resistant proinflammatory human myeloid cells for cancer immunotherapy. [PDF]

Mol Oncol
We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Barberi T, Friedman AD.
europepmc   +2 more sources

Differences between the CD34+ and CD34- blast compartments in apoptosis resistance in acute myeloid leukemia

Haematologica, 2003
BACKGROUND AND OBJECTIVES: Altered expression of members of the Bcl-2 family might account for the observed apoptosis resistance to chemotherapy in acute myeloid leukemia (AML). Given the poor prognosis associated with CD34+ expression in AML, we studied
A van Stijn, MA van der Pol, A Kok, PM Bontje, GM Roemen, RH Beelen, GJ Ossenkoppele, GJ Schuurhuis   +7 more
doaj   +1 more source

Prediction of Viable CD34 Count in Harvested Product by Peripheral Blood Hematopoietic Progenitor Count of Automated Hematology Analyzer Undergoing Hematopoietic Stem Cell Transplantation [PDF]

Journal of Blood Medicine
Siew Lian Chong,1,* Asral Wirda Ahmad Asnawi,1,2,* Tengku Amatullah Madeehah Tengku Mohd,2,* Sen Mui Tan1,* 1Department of Hematology, Hospital Ampang, Ampang Jaya, Selangor, Malaysia; 2Faculty of Medicine and Health Sciences, Universiti ...
Chong SL, Ahmad Asnawi AW, Tengku Mohd TAM, Tan SM   +3 more
doaj   +1 more source

Nilotinib concentration in cell lines and primary CD34+ chronic myeloid leukemia cells is not mediated by active uptake or efflux by major drug transporters [PDF]

, 2009
Imatinib mesylate and nilotinib are highly effective at eradicating the majority of chronic myeloid leukemia (CML) cells; however, neither agent induces apoptosis of primitive CML CD34⁺ cells.
Holyoake, T.L., Davies, A., Jordanides, N.E., Giannoudis, A., Jorgensen, H.G., Harris, R.J., Hatziieremia, S., Mountford, J.C., Pirmohamed, M., Clark, R.E., Lucas, C.M.   +10 more
core   +2 more sources

Stem Cell Antigen CD34 In Native And Engineered Form Alter Its Binding Ability To Stromal Cells And Ligands: A Classical Example Of Clinical Benefits Of Therapeutic Genetic Engineering Of Stem Cells In Transplantation [PDF]

, 2010
CD34 is a highly glycosylated surface-expressed sialomucin and, because it is present on hematopoietic stem cells (HSCs), has demonstrated immense clinical utility in their enumeration in aphaeresis products, immunoaffinity purification for ...
Yogesh Kumar Verma, Pallavi Gupta, Vimal Kumar Singh, Neeraj Kumar Satija, Rajendra Prasad Tripathi, Pallavi Gupta, Gurudutta Gangenahalli, Vimal Kumar Singh, Rajendra Prasad Tripathi   +8 more
core   +1 more source

A simple model system enabling human CD34+ cells to undertake differentiation towards T cells [PDF]

, 2013
Channelling the development of haematopoietic progenitor cells into T lymphocytes is dependent upon a series of extrinsic prompts whose temporal and spatial sequence is critical for a productive outcome.
B-Lynch Christopher, Lapenna, Antonio, Antonio Lapenna, Kapeni, Chrysa, Christopher B-Lynch, Richard Aspinall, Aspinall Richard, Kapeni Chrysa, B-Lynch, Christopher, Lapenna Antonio, Chrysa Kapeni, Aspinall, Richard   +11 more
core   +2 more sources

Milieu-adopted in vitro and in vivo differentiation of mesenchymal tissues derived from different adult human CD34-negative progenitor cell clones [PDF]

, 2005
Adult mesenchymal stem cells with multilineage differentiation potentially exist in the bone marrow, but have also been isolated from the peripheral blood.
Moser, C., Huss, R., Moosmann, S., Hutter, J., Krombach, F.   +4 more
core   +1 more source

The effects of bone marrow stem and progenitor cell seeding on urinary bladder tissue regeneration

Scientific Reports, 2021
Complications associated with urinary bladder augmentation provide the motivation to delineate alternative bladder tissue regenerative engineering strategies.
Matthew I. Bury, Natalie J. Fuller, Renea M. Sturm, Rebecca R. Rabizadeh, Bonnie G. Nolan, Milica Barac, Sonia S. Edassery, Yvonne Y. Chan, Arun K. Sharma   +8 more
doaj   +1 more source

Inhibition of MDR1 does not sensitize primitive chronic myeloid leukemia CD34⁺ cells to imatinib [PDF]

, 2009
<p><b>Objective:</b> To investigate the interaction of imatinib mesylate (IM) with the clinically relevant adenosine triphosphate-binding cassette efflux transporter MDR1 (ABCB1) in cells from patients with chronic myeloid leukemia (CML)
Holyoake, T.L., Jordanides, N.E., Jorgensen, H.G., Hatziieremia, S., Mountford, J.C.   +4 more
core   +1 more source

Improved arteriogenesis with simultaneous skeletal muscle repair in ischemic tissue by SCL plus multipotent adult progenitor cell clones from peripheral blood [PDF]

, 2004
Background: The CD34- murine stem cell line RM26 cloned from peripheral blood mononuclear cells has been shown to generate hematopoietic progeny in lethally irradiated animals.
Seliger, Christian, Huss, Ralf, Kinston, Sarah, Gottgens, Berthold, Heil, Matthias, Sabine Moosmann, Matthias Heil, Christian Seliger, Sabine Sagebiel, Berthold Gottgens, Tibor Ziegelhoeffer, Moosmann, Sabine, Ralf Huss, Sarah Kinston, Ziegelhoeffer, Tibor, Sagebiel, Sabine, Berthold Gottgensc, Tibor Ziegelhoefferb, Matthias Heilb, W Tissue, Sarah Kinstonc, Adult W Map-c, Sabine Sagebiela, Dr. Ralf Huss, Ralf Hussa, W Scl, Sabine Moosmanna, W Arteriogenesis, J Vasc Res, Christian Seligera   +29 more
core   +1 more source