Results 91 to 100 of about 807,388 (265)

Integrated PANoptosis Profiling Identifies Immunosuppressive Subtypes and a Prognostic Signature With Functional Validation of MLKL in Glioblastoma

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective The prognosis of glioblastoma (GBM) remains highly unfavorable, largely due to high tumor heterogeneity and an immunosuppressive microenvironment. However, the functional role of PANoptosis in this context is poorly understood. Methods Patients were stratified via K‐means clustering. A risk score model was constructed using prognosis‐
Langfei Tian, Minghui Zhao, Yuanbo Hu, Kaiyue Wang, Haiguang Liu, Zetong Bai, Kebin Zheng   +6 more
wiley   +1 more source

HIV negative aids-idiopathic CD4 lyphocytopenia

Journal of Indian Academy of Oral Medicine and Radiology, 2018
Idiopathic CD4+ T-cell lymphocytopenia (ICL) is a rare disorder of immune system with heterogeneous clinical manifestations and immunologic profile.
Ashima Bali Behl, Puneeta Vohra, Vikram Bali   +2 more
doaj   +1 more source

Susceptibility to intestinal infection and diarrhoea in Zambian adults in relation to HIV status and CD4 count. [PDF]

, 2009
BACKGROUND: The HIV epidemic in sub-Saharan Africa has had a major impact on infectious disease, and there is currently great interest in the impact of HIV on intestinal barrier function.
Feldman, RA, Roger A Feldman, Todd Jim, Mwansa, J, Henry Sinsungwe, H Sinsungwe (16116926), Feldman Roger A, Katubulushi, Max, Farthing Michael J, Paul Kelly, S Sianongo (16115693), Sianongo, Sandie, James Mwansa, Todd, Jim, Sianongo Sandie, Sinsungwe, H, M Katubulushi (16116548), Katubulushi, M, Sandie Sianongo, J Mwansa (16116545), Katubulushi Max, Farthing, MJ, P Kelly (9390197), R A Feldman (16116929), Sianongo, S, Michael J Farthing, Sinsungwe Henry, Sinsungwe, Henry, Kelly Paul, Mwansa James, M J Farthing (16115624), Farthing, Michael J, Feldman, Roger A, Mwansa, James, Kelly, Paul, Jim Todd, J Todd (9885689), Kelly, P, Todd, J, Max Katubulushi   +39 more
core   +2 more sources

Intracerebral Hemorrhage Induces Monocyte TNF Signaling in Patients That Is Suppressed by BAF312

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Intracerebral hemorrhage (ICH) causes high morbidity and mortality, with neurotoxic inflammation driven by infiltrating monocytes. This study is an in‐depth longitudinal examination of the immune response during the first week of ICH in the presence and absence of the immunomodulatory drug BAF312 (Siponimod).
Jonathan Howard DeLong, Sebastian Díaz‐Pérez, Kevin Navin Sheth, Jang‐Ho Cha, C. J. Malanga, Patricia G. M. Wagner, Nicole Pezous, Aurelie Hanin, Kyle B. Walsh, H. E. Hinson, Lauren Hachmann Sansing   +10 more
wiley   +1 more source

Early Clinical and Cerebrospinal Fluid Predictors of 1‐Year Recurrence in Autoimmune GFAP Astrocytopathy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Autoimmune glial fibrillary acidic protein astrocytopathy (GFAP‐A) is an inflammatory central nervous system disorder with variable outcomes. Relapse occurs in a subset of patients, but early predictors remain unclear. We aimed to identify admission‐available features associated with 1‐year recurrence and develop an interpretable ...
Qingting Hong, Yuping Xiao, Yuhan Wu, Ziyuan Huang, Weishan Liang, Li Xiao, Yaqing Shu, Tingting Lu, Yanyu Chang, Wei Qiu, Yuge Wang   +10 more
wiley   +1 more source

Endogenous human cytomegalovirus gB is efficiently presented by MHC class II molecules to CD4+ CTL [PDF]

, 2005
Human cytomegalovirus (HCMV) infects endothelial, epithelial, and glial cells in vivo. These cells can express MHC class II proteins, but are unlikely to play important roles in priming host immunity.
Nelson, JA, Dunn, C, Johnson, DC, Hegde, NR, Lewinsohn, DM, Jarvis, MA   +5 more
core  

CD4-independent use of the CCR5 receptor by sequential primary SIVsm isolates-4

, 2011
Copyright information:Taken from "CD4-independent use of the CCR5 receptor by sequential primary SIVsm isolates"http://www.retrovirology.com/content/4/1/50Retrovirology 2007;4():50-50.Published online 23 Jul 2007PMCID:PMC1950888.time in 13 macaques ...
Rigmor Thorstensson (54920), Anna Laurén (54917), Eva Maria Fenyö (54921), Elzbieta Vincic (54918), Hiroo Hoshino (54919)   +4 more
core   +1 more source

Clinical Characteristics and Concordance of Anti‐MDA5 Antibodies: A Multicenter Australian Study

Arthritis Care &Research, EarlyView.
Objective In Australia, anti‐MDA5 antibodies are exclusively tested by a line immunoblot assay (LIA). The clinical concordance of an LIA‐positive anti‐MDA5 result is unclear. We aimed to describe the clinical features and determine the clinical concordance of patients with anti‐MDA5 antibodies. Methods Electronic records of a multisite cohort (patients
Syed B. Ali, Thomas Khoo, Keeran Shivakumar, Adam Caroll, Lauren Hender, Dimitra Beroukas, Kim Griggs, Celina Jin, Theo De Malmanche, Jessica Day, Gabor Major, Vidya Limaye   +11 more
wiley   +1 more source

Prevalence and Predictors of CD4+ T-Lymphocytopenia Among HIV-Negative Tuberculosis Patients in Uganda

Research and Reports in Tropical Medicine, 2020
Joseph Baruch Baluku,1– 3 Joseph Musaazi,4 Rose Mulwana,1 Araali Robert Mugabo,1 Felix Bongomin,5 Winceslaus Katagira3 1Mulago National Referral Hospital, Pulmonology Division, Kampala, Uganda; 2Mildmay Uganda, Kampala, Uganda; 3Makerere University
Baluku JB, Musaazi J, Mulwana R, Mugabo AR, Bongomin F, Katagira W   +5 more
doaj  

Reference Intervals for Absolute and Percentage CD4+ T Lymphocytes among an Apparently Healthy Population in Addis Ababa, Ethiopia

International Journal of General Medicine, 2022
Dinkenesh Chalchisa,1,2 Yohannes Belay,1 Endalkachew Befekadu,3 Melkitu Kassaw,4 Letebrhan G/Egzeabher,5 Gebremedhin Gebremicael,1 Boki Lengiso,1 Dawit Chala,1 Zewdineh Sahlemariam,6 Estifanos Kebede,6 Ebba Abate,4 Aster Tsegaye2 1National HIV Reference ...
Chalchisa D, Belay Y, Befekadu E, Kassaw M, G/Egzeabher L, Gebremicael G, Lengiso B, Chala D, Sahlemariam Z, Kebede E, Abate E, Tsegaye A   +11 more
doaj