Results 31 to 40 of about 807,388 (265)

In vitro generation of regulatory T cells: A challenging tool for studying immune aging in humans [PDF]

FEBS Open Bio
In vitro induction of human regulatory T cells using standard protocols generates suppressive, Foxp3‐expressing CD4+ T cells independently of TGF‐β supplementation and donor age. Regulatory T (Treg) cells play a key role in immune tolerance and homeostasis.
Muller L, Bleher J, Weinberger B, Rocamora‐Reverte L.   +3 more
europepmc   +2 more sources

CD4+count-guided interruption of antiretroviral treatment [PDF]

, 2006
BACKGROUND:Despite declines in morbidity and mortality with the use of combination antiretroviral therapy, its effectiveness is limited by adverse events, problems with adherence, and resistance of the human immunodeficiency virus (HIV).METHODS:We ...
Babiker, A, Lundgren, JD, Faetkenheuer, G., Rappoport, C, Hoy, Jennifer, El-Sadr, Wafaa, Arduino, RC, Grund, B, Abrams, DJ, Clumeck, Nathan, Strategies for Management of Antiretroviral Therapy (SMART) Stud, Clumeck, N., Gazzard, B, Neuhaus, J, Neaton, J. D., Lundgren, J. D., Darbyshire, J, Grund, Birgit, Hoy, J., Phillips, A., Fätkenheuer, Gerd, Neaton, James, Lundgren, Jens D, Cohn, D., Cohen, C. J., Mejia, JMR, Strategies Management Antiretrovir, Darbyshire, J., Emery, S, Klingman, Karin, Darbyshire, Janet, Markowitz, Norman, Emery, Sean, Cohn, David V., Cooper, David, Gordin, Fred, Emery, S., Losso, M, Losso, Marcello, Klingman, K, Neaton, JD, Clumeck, N, Markowitz, N., Babiker, Abdel, Cooper, D., Losso, M., Mejia, J. M. Ramos, Arduino, R. C., Gordin, F, Fatkenheuer, G, Cohen, Calvin, Hoy, J, Neuhaus, J., El-Sadr, W. M., Grund, B., Klingman, K., El-Sadr, WM, Cohn, D, Gazzard, Brian, Burman, William, Burman, W., Abrams, D, Cohen, CJ, Gazzard, B., Arduino, Roberto, Markowitz, N, Gordin, F., Babiker, A., Burman, W, Cooper, D, Abrams, D., Phillips, Andrew N., Phillips, A, Rappoport, C.   +73 more
core   +1 more source

Effects of fermented Crescentia cujete L. on the profile of haematology, clinical chemistry and circulatory CD4+/CD8+ in Sprague Dawley rats

Open Veterinary Journal
Background: The calabash (Crescentia cujete L.) is a tropical fruit that offers numerous health benefits. Its fermented form (FC) has been found to affect the neurological system positively.
Agustina Dwi Wijayanti, Yos Adi Prakoso, Krestel Joy Viernes Isla   +2 more
doaj   +1 more source

HLA‐Bw4 homozygosity is associated with an impaired CD4 T cell recovery after initiation of antiretroviral therapy [PDF]

, 2008
We assessed the influence of human leukocyte antigen (HLA) alleles HLA-Bw4 and HLA-Bw6 on CD4 T cell recovery after starting successful combination antiretroviral therapy in 265 individuals. The median gains in the CD4 T cell count after 4 years were 258
Battegay, Manuel, Günthard, Huldrych F, Gaudieri, S., Swiss, HIV Cohort Study, John, Mina, Nolan, David, James, Ian, Furrer, H, Schmid, P, Battegay, M., McKinnon, E, Rauch, A., Swiss HIV Cohort Study, ., McKinnon, E., Telenti, A, Günthard, Huldrych F., Schmid, Patrick, Rauch, A, John, M., James, I, Furrer, Hansjakob, Hirschel, Bernard, Telenti, Amalio, Schmid, P., Furrer, H., Rauch, Andri, John, M, Günthard, H.F., Mallal, Simon, Telenti, A., McKinnon, Elizabeth, Nolan, D., Günthard, H F, Hirschel, B, Günthard, H. F., Battegay, M, Hirschel, B., Nolan, D, Mallal, S, James, I., Gaudieri, Silvana, Mallal, S., Gaudieri, S, John M, Battegay M, James I, Nolan D, Gaudieri S, Rauch A, Mallal S, Schmid P, Telenti A, Furrer H, McKinnon E, Hirschel B, Günthard HF   +55 more
core   +2 more sources

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Analysis Activity of Elephantopus scaber Leaves Extract Against Quantitative Changes of Lymphocytes Cells in BALB/c Mice After Induction of DMBA and Estrogen

Journal of Experimental Life Science, 2019
The carcinogenic compounds such as DMBA known for having the ability to promote the DNA damage that affects the growth regulator genes. Therefore, uncontrolled cell growth will occur and change the immune system. Elephantopus scaber extract is considered
Lailiyavina Rochmatika, Sri Widyarti, Muhammad Sasmito Djati   +2 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Tapak liman (Elephantopus scaber L) Extract Induced CD4+ and CD8+ Differentiation from Hematopoietic Stem Cell/Progenitor Cell Proliferation of Mice (Mus musculus)

Journal of Experimental Life Science, 2015
Tapak liman (Elephantopus scaber L) is one of the traditional medicinal plants, which are containing several active compounds that potentially affecting hematopoietic.
M. Sasmito Djati, Hindun Habibu, Nabilah A Jatiatmaja, Muhaimin Rifa'i   +3 more
doaj   +1 more source

Pan-cancer landscape of aberrant DNA Methylation across childhood Cancers: Molecular Characteristics and Clinical relevance

Experimental Hematology & Oncology, 2022
Aberrant DNA methylation (DNAm) is an important epigenetic regulator in various cancers. Pan-cancer DNAm analyses have investigated the potential common mechanisms of DNAm in tumorigenesis.
Zheng Dong, Hongyu Zhou
doaj   +1 more source

Role of CD4 epitopes outside the gp120-binding site during entry of human immunodeficiency virus type 1 [PDF]

, 1997
CD4 is the primary receptor for human immunodeficiency virus (HIV). The binding site for the surface glycoprotein of HIV type 1 (HIV-1), gp120, has been mapped to the C'-C" region of domain 1 of CD4. Previously, we have shown that a mutant of rat CD4, in
Puklavec, M., Stumbles, P.A., James, W., Somoza, C., Signoret, N., Simon, J.H.M, Sattentau, Q.J., Barclay, A.N.   +7 more
core