Results 51 to 60 of about 807,388 (265)

The ubiquitin system in normal and infected germinal center B cells

FEBS Letters, EarlyView.
The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis, Lesly Mejia, Emily K Moser   +2 more
wiley   +1 more source

IL-10 from CD4(+)CD25(-)Foxp3(-)CD127(-) adaptive regulatory T cells modulates parasite clearance and pathology during malaria infection [PDF]

, 2008
The outcome of malaria infection is determined, in part, by the balance of pro-inflammatory and regulatory immune responses. Failure to develop an effective pro-inflammatory response can lead to unrestricted parasite replication, whilst failure to ...
Couper, Kevin N, Hafalla, Julius C, Riley, Eleanor M, Daniel G. Blount, Eleanor M Riley, Blount, Daniel G., Kevin N Couper, Richard A Flavell, Wilson, MS, de Souza, J Brian, Daniel G Blount, Mark S Wilson, Couper, KN, Blount, DG, Kamanaka, Masahito, Wilson, Mark S, Julius C. Hafalla, Belkaid, Yasmine, Masahito Kamanaka, Blount, Daniel G, Flavell, Richard A, Flavell, Richard A., J. Brian de Souza, Flavell, RA, De Souza, J. Brian, Kevin N. Couper, Kamanaka, M, Hafalla, Julius C., Julius C Hafalla, Eleanor M. Riley, Hafalla, JC, Riley, Eleanor M., Belkaid, Y, Yasmine Belkaid, De Souza, JB, Mark S. Wilson, Richard A. Flavell, Couper, Kevin N., Wilson, Mark S., Riley, EM, J Brian de Souza   +40 more
core   +2 more sources

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Estrogen and progesterone attenuate CD4-positive immune cell traffic to the penumbra region of rat’s ischemic stroke brain [PDF]

Iranian Journal of Basic Medical Sciences
Objective(s): Stroke is an acute cerebrovascular disease with a high incidence, high disability rate, and high mortality. Stroke damages the integrity of the blood-brain barrier.
Aboutaleb Tamtaji, Sayyed Alireza Talaei, Homayoun Naderian, Mohammad Ali Atlasi, Nasim Alipour, Abolfazl Azami-Tameh   +5 more
doaj   +1 more source

Neutralization of the PTX3/CD44 axis suppresses TGF‐β1 signaling in kidney fibrosis

FEBS Letters, EarlyView.
This study investigates how the PTX3/CD44 axis promotes kidney fibrosis by activating TGF‐β1 signaling. We demonstrate that the neutralizing antibody WHC‐001 effectively inhibits this pathway, suppressing myofibroblast activation and partial epithelial–mesenchymal transition (EMT).
Chao‐Chun Cheng, Shen‐Shin Chang, Feng‐Wei Chen, Ying‐Chieh Su, Thanh Phuong Nguyen, Yu‐Wei Hsiao, Jhih‐Ying Chi, Hsin‐Yin Liang, Ju‐Ming Wang   +8 more
wiley   +1 more source

Clinico-demographic profile of patients with HIV/tuberculosis co-infection from western Gujarat, India: a retrospective study

HIV & AIDS Review. International Journal of HIV-Related Problems
Introduction Human immunodeficiency virus (HIV)/tuberculosis (TB) co-infection has become huge barrier to achieving TB control in the world. TB, despite being discovered in 1882, remains a major public health problem in many developing countries.
Parth U. Patel, Chandra S. Purohit, Kalpesh B. Patel   +2 more
doaj   +1 more source

The rate of CD4 decline as a determinant of progression to AIDS independent of the most recent CD4 count [PDF]

, 1998
The data of two cohort studies of HIV-infected individuals were used to examine whether the rate of CD4 decline is a determinant of HIV progression, independent of the most recent CD4 count.
Lepri, AC, Phillips, AN, Lee, CA, Pezzotti, P, Rezza, G, Sabin, CA   +5 more
core  

Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy

FEBS Letters, EarlyView.
The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley   +1 more source

Immunomodulator effect of Cnidoscolus aconitifolius leaves extract on CD4+ and CD8+ expression in Salmonella typhimurium-infected mice [PDF]

Pharmaciana
Typhoid fever is a common health problem in the community caused by Salmonella bacteria. The incidence rate of this infection will increase if a person’s immune system is weakened.
Sholihatil Hidayati, Dhina Ayu Susanti, Rian Anggia Destiawan, Ahdiah Imroatul Muflihah, Rizka Handayani, Wima Anggitasari   +5 more
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source