Results 201 to 210 of about 580,131 (264)

Chronic HBV Infection Disrupts CCL5‐Secreting cNK Cells and Attenuates Liver Accumulation and Activation of DCs and HBV‐Specific T Cells

Advanced Science, EarlyView.
ADORA2A activation suppresses NFκB‐dependent CCL5 production in cNK cells during chronic HBV infection, disrupting intrahepatic DC recruitment and HBV‐specific CD8+ T‐cell differentiation and function. Targeting the ADORA2A/NFκB/CCL5 axis restores antiviral immunity and facilitates HBV clearance.
Ailu Yang, Yucan Wang, Yating Yu, Jing Wu, Cuiping Bao, Zixuan Wang, Qiuju Han, Zhigang Tian, Jian Zhang, Huajun Zhao   +9 more
wiley   +1 more source

Single-cell transcriptome delineating asymmetric dynamics of CD4⁺ T and CD8⁺ T cell lineage commitment in human prenatal thymus. [PDF]

Front Immunol
Yang Y, Yao Y, Jibu S, Yin Y, Li Z, Ni Y, Liu B, Lan Y.   +7 more
europepmc   +1 more source

SPSB1 Promotes Subcutaneous Adipose Hyperplasia in Facial Port‐Wine Stains by Controlling HDAC1 Degradation and Stability Through Two Distinct Proteolytic Pathways

Advanced Science, EarlyView.
In PWS‐ASPCs, FOSL1 drives the expression of SPSB1. SPSB1, as part of the ESC complex, further binds to HDAC1 and promotes K29‐linked and K48‐linked polyubiquitination of HDAC1. These modifications facilitate the degradation of HDAC1 through the ALP and UPS pathways, respectively.
Hongrui Chen, Bin Sun, Yajing Qiu, Chen Hua, Xiaoxi Lin, Wei Gao   +5 more
wiley   +1 more source

Brain Immune Cell Composition in Multiple Sclerosis and Progressive Multifocal Leukoencephalopathy After Natalizumab: An Immunohistochemical Cohort Study. [PDF]

Neurol Neuroimmunol Neuroinflamm
Raabe BS, Stork L, Kutllovci A, Goelz SE, Metz I.   +4 more
europepmc   +1 more source

Programmable Encapsulation Enables On‐Demand Proliferation of Therapeutic Bacteria for Potent Cancer Immunotherapy

Advanced Science, EarlyView.
A programmable encapsulation technology is developed to reduce bacterial immunogenicity and proliferation after systemic administration. The cross‐linked polymer networks around individual bacteria enable immunogenic shielding and permit selective proliferation in tumors, allowing the bacteria to convert tumor‐accumulated ammonia into L‐arginine and ...
Jianhui Yang, Ao Peng, Shuaiqiang Li, Yaning Huang, Jian Yan, Leyuan Wang, Zhihui Zhu, Fei‐Long Liu, Erbao Bian, Yang Liu, Dasheng Tian, Fenghe Li, Qi Liu   +12 more
wiley   +1 more source

Dominant T cell receptor clonotypes in adrenocorticotropic hormone-secreting pituitary carcinoma are the highest-frequency clones among CD4⁺ and CD8⁺ cells in peripheral blood during effective anti-PD-1 therapy. [PDF]

Front Immunol
Sugiyama M, Iwama S, Takeuchi K, Kobayashi T, Murase T, Hagiwara D, Chen H, Nagata Y, Saito R, Akatsuka Y, Arima H.   +10 more
europepmc   +1 more source

Immediate Growth Control in Response to Boiling Histotripsy is Prognostic for Intratumoral Immune Activation

Advanced Science, EarlyView.
Boiling Histrotripsy (BH), a mechanical form of focused ultrasound (FUS), allows for non‐invasive and non‐ionizing tissue destruction. Utilizing a BH treatment protocol that yielded bifurcating primary tumor growth responses, we found that immediate BH‐induced tumor growth control identifies tumors with acute reductions in antigen‐presenting cells (APC)
Lydia E. Kitelinger, Matthew R. DeWitt, Carly M. Van Wagoner, Claire A. Conarroe, Charles C. Funk, Aaron B. Streit, AeRyon Kim, Richard J. Price, Timothy N. J. Bullock   +8 more
wiley   +1 more source

Diverse Roles of Semaphorins on T Cell Activation, Differentiation, Migration, and Effector Functions. [PDF]

Cells
Ma H, Gounni AS, Su RC, Kung SKP.
europepmc   +1 more source

Peripheral immune cell subsets as potential predictors of benefit from immune checkpoint blockade therapy in small cell lung cancer. [PDF]

Front Immunol
Galindo-Campos MA, Hardy-Werbin M, Gibert J, Pucci M, Hernández-Prat A, Ríos-Hoyo A, Rocha P, Rossell A, Del Rey-Vergara R, Parreira A, Pellicer A, Taus Á, Rovira A, Arriola E.   +13 more
europepmc   +1 more source

PPP2R3C serves as a negative regulator associated with reduced T cell hyperactivation and renal protection in lupus. [PDF]

Clin Transl Med
Fang X, Qin Y, Tao J, Zhou Z, Cai M, Zhang H, Li X, Li X, Chen Z.   +8 more
europepmc   +1 more source