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CD4 and the Immunopathology of AIDS
American Journal of Respiratory Cell and Molecular Biology, 1989Since its original description as a lymphoycte differentiation antigen in 1980, much has been learned about the cell surface glycoprotein CD4. Initially identified on T lymphocytes with helper/inducer function, CD4 has a wider distribution and is present on some T lymphocytes with suppressor, cytotoxic, or macrophage-activating function.
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Rheumatic Disease Clinics of North America, 1998
Animal models of human autoimmune disease suggest that it should be possible to reinduce self-tolerance in these conditions by the use of T-cell directed therapies, in particular with anti-CD4 monoclonal antibodies (CD4-mAb). Many studies have shown that CD4-mAb can prevent and in a treatment setting suppress activity of these disease models, including
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Animal models of human autoimmune disease suggest that it should be possible to reinduce self-tolerance in these conditions by the use of T-cell directed therapies, in particular with anti-CD4 monoclonal antibodies (CD4-mAb). Many studies have shown that CD4-mAb can prevent and in a treatment setting suppress activity of these disease models, including
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1996
The CD4 molecule plays an important role in the development of CD4+T lymphocytes and it also acts as a coreceptor to enhance responses mediated via the TCR. It is now established that CD4 functions both as an adhesion molecule favoring the T cell: APC interaction and as a signaling molecule.
K S, Ravichandran +2 more
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The CD4 molecule plays an important role in the development of CD4+T lymphocytes and it also acts as a coreceptor to enhance responses mediated via the TCR. It is now established that CD4 functions both as an adhesion molecule favoring the T cell: APC interaction and as a signaling molecule.
K S, Ravichandran +2 more
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CD42b Immunostaining as a Marker for Placental Fibrinoid in Normal Pregnancy and Complications*
Fetal and Pediatric Pathology, 2021Peilin Zhang
exaly
Endocytosis and recycling of CD4
Biochemical Society Transactions, 1990Marsh, M, Armes, JE, Pelchenmatthews, A
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