Results 71 to 80 of about 314,352 (325)

CD3+CD4+CD8+ T-LYMPHOCYTES COUNT IN PROGNOSIS OF EARLY KIDNEY ALLOGRAFT DYSFUNCTION

Žurnal Grodnenskogo Gosudarstvennogo Medicinskogo Universiteta, 2020
Background. Double-positive CD3+CD4+CD8+ T-lymphocytes are significant in the immune response to various infectious agents. Pancreatic islet transplantation in the experiment characterizes CD3+CD4+CD8+ as a new biomarker for donor cells rejection ...
Zybleva S. V., Zyblev S. L.
doaj   +1 more source

High CD4+ T-Cell/B-Cell Ratio in the Paranasal Sinus Mucosa of Patients with Eosinophilic Chronic Rhinosinusitis

International Archives of Otorhinolaryngology, 2021
Introduction Chronic rhinosinusitis (CRS) is commonly classified based on the presence or absence of nasal polyps (NPs). Eosinophil infiltration is observed in NPs of patients in Western countries.
Akiko Inoue, Yuriko Tanaka, Shinya Ohira, Kentaro Matsuura, Motonari Kondo, Kota Wada   +5 more
doaj   +1 more source

Strain- and dose-dependent reduction of Toxoplasma gondii burden in pigs is associated with interferon-gamma production by CD8+ lymphocytes in a heterologous challenge model [PDF]

, 2017
Toxoplasma gondii is a worldwide prevalent parasite of humans and animals. The global infection burden exceeds yearly one million disability-adjusted life years (DALY's) in infected individuals. Therefore, effective preventive measures should be taken to
Bert Devriendt, Eric Cox, Katelijne Dierick, Malgorzata Jennes, Pierre Dorny, Pierre Dorny, Stéphane De Craeye   +6 more
core   +2 more sources

Multi‐omic characterization of consensus molecular subtype 1 (CMS1) colorectal cancer with dampened immune response improves precision medicine

Molecular Oncology, EarlyView.
This study highlights the importance of multi‐omic analyses in characterizing colorectal cancers. Indeed, our analysis revealed a rare CMS1 exhibiting dampened immune activation, including reduced PD‐1 expression, moderate CD8+ T‐cell infiltration, and suppressed JAK/STAT pathway.
Livia Concetti, Manuel Scimeca, Julia Bischof, Jonathan Woodsmith, Massimiliano Agostini, Cristina Fiorani, Yufang Shi, Eleonora Candi, Gerry Melino, Alessandro Mauriello, Giuseppe S. Sica   +10 more
wiley   +1 more source

Trans-active factors controlling the IL-2 gene in adult human T-cell subsets

Mediators of Inflammation, 1992
IL-2 secretion in total or subsets of PHA/PMA-stimulated PBMC-derived human T-lymphocytes was monitored and found to be largely due to CD4+CD8− cells. The presence and functional state of transcription factors (TF) was assessed by protein-DNA interaction
A. Mouzaki, R. H. Zubler, A. Doucet, D. Rungger   +3 more
doaj   +1 more source

ROLE OF HEPATITIS C VIRUS COINFECTION IN VIOLATION OF PRODUCTIVE THYMIC FUNCTION IN HIV-INFECTED PATIENTS UNDER IMMUNOLOGICALLY INEFFICIENT ANTIRETROVIRAL THERAPY

Медицинская иммунология, 2014
. The role of hepatitis C virus (HCV) co-infection in violation of restoring CD4+T cells in HIVinfected patients receiving antiretroviral therapy (ART) was investigated.
E. V. Saidakova, L. B. Korolevskaya, N. G. Shmagel, K. V. Shmagel, V. A. Chereshnev   +4 more
doaj   +1 more source

Restoring Lost Anti-HER-2 Th1 Immunity in Breast Cancer: A Crucial Role for Th1 Cytokines in Therapy and Prevention [PDF]

, 2016
The ErbB/B2 (HER-2/neu) oncogene family plays a critical role in the development and metastatic spread of several tumor types including breast, ovarian and gastric cancer.
Czerniecki, Brian J., De La Cruz, Lucy M., Lee, M. Catherine, Nocera, Nadia F., Rosemblit, Cinthia   +4 more
core   +2 more sources

Comprehensive omics‐based classification system in adult patients with B‐cell acute lymphoblastic leukemia

Molecular Oncology, EarlyView.
The COMBAT classification system, developed through multi‐omics integration, stratifies adult patients with B‐cell acute lymphoblastic leukemia(B‐ALL) into three molecular subtypes with distinct surface antigen patterns, immune landscape, methylation patterns, biological pathways and prognosis.
Yang Song, Ting Liu, Qishan Hao, Qiuyun Fang, Xiaoyuan Gong, Yan Li, Zheng Tian, Hui Wei, Min Wang, Jianxiang Wang, Tao Cheng, Yingchang Mi   +11 more
wiley   +1 more source

Systemic Cytokine Profiles of CD4+ T Lymphocytes Correlate with Clinical Features and Functional Status in Stable COPD

International Journal of COPD, 2020
Juliana Souza Uzeloto,1 Alessandra Choqueta de Toledo-Arruda,2 Bruna Spolador de Alencar Silva,1 Marjorie de Assis Golim,3 Aline Márcia Marques Braz,3 Fabiano Francisco de Lima,1 Isis Grigoletto,1 Ercy Mara Cipulo Ramos1 1São Paulo State ...
Uzeloto JS, Toledo-Arruda AC, Silva BSA, Golim MA, Braz AMM, Lima FF, Grigoletto I, Ramos EMC   +7 more
doaj  

Analysis of Cellular Component Indicators of Immune Status of Rhesus Macaques

Проблемы особо опасных инфекций, 2021
Objective. Selection of indicators of lymphocyte populations in rhesus macaques determined by flow cytometry to evaluate variations of cellular constituent of their immune status.Materials and methods.
G. V. Borisevich, S. L. Kirillova, O. N. Sidorova, V. N. Lebedev, A. A. Petrov, A. V. Ovchinnikov, I. V. Shatokhina, T. E. Sizikova, V. E. Sazonov, E. S. Mukhacheva, S. V. Borisevich   +10 more
doaj   +1 more source