Results 71 to 80 of about 831,770 (328)

CD4 cell count recovery among HIV-infected patients with very advanced immunodeficiency commencing antiretroviral treatment in sub-Saharan Africa. [PDF]

, 2006
BACKGROUND: Patients accessing antiretroviral treatment (ART) programmes in sub-Saharan Africa frequently have very advanced immunodeficiency. Previous data suggest that such patients may have diminished capacity for CD4 cell count recovery.
Myer, Landon, Landon Myer, Lawn Stephen D, Wood Robin, Lawn, Stephen, Linda-Gail Bekker, Lawn, Stephen D, Robin Wood, Bekker, Linda-Gail, Bekker Linda-Gail, Myer Landon, Stephen D Lawn, Wood, Robin   +12 more
core   +1 more source

Tailoring Vascular‐Immune Homeostasis via Manganese‐DNA Complex‐Armed Immunogenic Extracellular Vesicles for Pancreatic Cancer Immunotherapy

Advanced Science, EarlyView.
This study demonstrates that Mn2⁺–tumor DNA complexes encapsulated in dendritic cell (DC)– derived immunogenic extracellular vesicles (EVDC@Mn‐DNA) act as a DC‐specific cGAS– STING activator. EVDC@Mn‐DNA treatment enhances intratumoral DC activation, improves tumor vascular function, promotes CD8⁺ T cell activity, and suppresses pancreatic tumor growth,
Xue Jiang, Lihuan Shang, Xiaochun Chen, Xiangzhan Kong, Xiaojuan Wang, Linjia Jiang, Huiying Zhao, Yafeng Zhu, Cheng Huang, Shiyi Deng, Rui Zhang, Minghui Wang, Haoming Lin, Ping‐Pui Wong   +13 more
wiley   +1 more source

In situ characterisation of CD4+ t cell behaviour in mucosal and systemic lymphoid tissues during the induction of oral priming and tolerance [PDF]

, 2005
The behavior of antigen-specific CD4+ T lymphocytes during initial exposure to antigen probably influences their decision to become primed or tolerized, but this has not been examined directly in vivo.
Smith, Karen M, Zinselmeyer, BH, Zinselmeyer, Bernd H, Smith, KM, Rush, C.M., Rush, Catherine M., Michael Cahalan, Ho, H., Smith, K.M., Ian Parker, Wokosin, D, Rush, Catherine M, Cahalan, M., Cahalan, Michael, Miller, M., Dempster, J., Millington, OR, Gurney, Alison M.; id_orcid, Parker, I., Ho, Hsiang, Calahan, M., Mark Miller, Millington, Owain R., Parker, I, Rush, CM, Garside, P, Alison M. Gurney, Millington, Owain R, Bernd H. Zinselmeyer, Gurney, A.M., Dempster, J, Wokosin, D.L., Paul Garside, Owain R. Millington, Millington, O.R., Catherine M. Rush, Smith, Karen M., Wokosin, D., Hsiang Ho, Dempster, John, Karen M. Smith, John Dempster, Parker, Ian, Gurney, Alison M, Brewer, James M, Gurney, Alison M., Ho, H, Cahalan, M, Millington, A.R., Wokosin, David, Zinselmeyer, B.H., Zinselmeyer, B. H., Brewer, James M., Brewer, J.M., Miller, M, Gurney, AM, David Wokosin, Garside, P., Zinselmeyer, Bernd H., Miller, Mark, James M. Brewer, Garside, Paul, Brewer, JM   +62 more
core   +1 more source

PD‐1 Inhibits CD4+ TRM‐Mediated cDC1 Mobilization via Suppressing JAML in Human NSCLC

Advanced Science, EarlyView.
CD4+ tissue‐resident memory T cells (TRMs) in non‐small cell lung cancer recruit conventional type 1 dendritic cells via XCL1‐XCR1 signaling, orchestrating antitumor immunity. The costimulatory molecule JAML is essential for this process. PD‐1 blockade restores JAML expression and cDC1 mobilization, while JAML agonists synergize with anti‐PD‐1 therapy,
Zheyu Shao, Qinyuan Liu, Zhongwei Xin, Zhiyao Zhou, Mingjie Lin, Di Chen, Zhixing Hao, Yongyuan Chen, Wenxuan Wu, Shuyang Zhang, Xiaoke Chen, Xia Xu, Jinfan Li, Wei Lin, Yuhao Lu, Dang Wu, Pin Wu   +16 more
wiley   +1 more source

Varicella-zoster virus infection of a human CD4-positive T-cell line.

Virology, 2000
Varicella-zoster virus (VZV) is a human alpha-herpesvirus that causes varicella (chickenpox) at primary infection and may reactivate as herpes zoster. VZV is a T-lymphotropic virus in vivo.
Leigh Zerboni, M. Sommer, C. F. Ware, Ann M. Arvin   +3 more
semanticscholar   +1 more source

Decrease in CD4 and CD8 lymphocytes are predictors of severe clinical picture and unfavorable outcome of the disease in patients with COVID-19

Open Medicine
The main objective of this study was to investigate the association between CD4+ and CD8+ lymphocyte values and disease severity, need for oxygen therapy and disease outcomes.
Jovičić Biljana Popovska, Raković Ivana, Đorđević Nemanja, Gavrilović Jagoda, Čanović Predrag, Marjanović Ružica Radojević, Petrović Sara, Milosavljević Katarina B., Divjak Ana, Stanković Nenad, Paunović Milan, Milosavljević Miloš Z.   +11 more
doaj   +1 more source

Detection and Significance of CD4+CD25+CD127dim Regulatory T Cells in Individuals with Severe Aplastic Anemia

Turkish Journal of Hematology, 2015
INTRODUCTION: To investigate the relationship between CD4+CD25+CD127dim regulatory T cells (Tregs) and immune imbalance in acquired severe aplastic anemia (SAA).
Weiwei Qi, Yue Ren, Rong Fu, Huaquan Wang, Chunyan Liu, Zonghong Shao   +5 more
doaj   +1 more source

Human CD4+ Memory T Cells Can Become CD4+IL-9+ T Cells [PDF]

, 2010
Background: IL-9 is a growth factor for T- and mast-cells that is secreted by human Th2 cells. We recently reported that IL-4+TGF-β directs mouse CD4+CD25−CD62L+ T cells to commit to inflammatory IL-9 producing CD4+ T cells.
Popoola, Joyce, Wenda Gao, Terry B Strom, Gao Wenda, Strom, Terry B., Strom Terry B., Strom, TB, Putheti, P, Popoola, J, Awasthi, A, Amit Awasthi, Awasthi Amit, Prabhakar Putheti, Popoola Joyce, Awasthi, Amit, Putheti Prabhakar, Joyce Popoola, Gao, W   +17 more
core   +1 more source

CDK4/6 Inhibition Induces CD8+ T Cell Antitumor Immunity via MIF‐Induced Functional Orchestration of Tumor‐Associated Macrophages

Advanced Science, EarlyView.
CDK4/6 inhibition promotes CD8+ T cell expansion through tumor‐macrophage crosstalk by activating HIF‐1α and enhancing MIF‐CD44/CD74 signaling. This reprograms TAMs to boost MHC‐I antigen presentation, and CDK4/6 inhibitor‐trained M1 TAM supernatant therapy synergizes with low‐dose PD‐1 blockade to restore antitumor immunity.
Lin He, Yuzhong Peng, Lat‐lun Leong, Jingbo Zhou, Dongyang Tang, Weilu Wang, Xiaoran Wu, Josh haipeng Lei, Yongqin Ye, Yangyang Feng, Yunfeng Qiao, Xiangpeng Chu, Di Mu, Qi Zhao, Tzuming Liu, Yan Chen, Paul Kwonghang Tam, Chu‐Xia Deng   +17 more
wiley   +1 more source

Interferon-gamma-mediated suppression of erythroid progenitor growth by a HLA-DR- and CD4-positive subset of T lymphocytes in acute myeloid leukemia

Immunobiology, 1992
In this study, we examined the effects of peripheral blood T lymphocytes from patients with acute myeloid leukemia (AML) on marrow-derived erythroid progenitors (BFU-DE and CFU-DE) growth in an in vivo culture by using the plasma clot diffusion chamber (DC) technique.
J, Hansz, M, Kozlowska-Skrzypczak
openaire   +2 more sources