Results 121 to 130 of about 1,048,882 (334)

Engineered ETS1‐Nanoconjugate Restores Immune Homeostasis through Dual Immune‐Vascular Modulation in Relapsing and Progressive Multiple Sclerosis

Advanced Healthcare Materials, EarlyView.
The biomimetic nanoplatform IMNP (ETS1 pDNA/PBAE@ITP‐MM) undergoes targeted disassembly at inflammatory vascular sites to release the ETS1 plasmid (pETS1). This release initiates a cascade of effects that inhibit pathogenic pathways and support immune homeostasis. (Abbreviations: EndMT, endothelial‐to‐mesenchymal transition; EC, endothelial cell; TC, T
Feng Zhang, Si‐Bo Yang, Yan Luo, Xiao‐Di Sun, Bo‐Hao Chang, Da‐Qiang Zhou, Jun‐Jie Jiang, Ya‐Nan Li, Jie‐Hong Wu, Hui‐Juan Jin, Hang Yang, Hang Hu, Yi‐Fan Zhou, Bo Hu   +13 more
wiley   +1 more source

Gene Expression Patterns Associated with Tumor-Infiltrating CD4+ and CD8+ T Cells in Invasive Breast Carcinomas

, 2020
zhanwei Wang, Jiamin Xu, Xi Yang, Yuefen Pan, Junjun Shen, Jin Liu, Shuwen Han   +6 more
openalex   +1 more source

Autologous stem cell transplantation for autoimmunity induces immunologic self-tolerance by reprogramming autoreactive T cells and restoring the CD4+CD25+ immune regulatory network [PDF]

, 2005
Ismé de Kleer, Sebastiaan J. Vastert, Mark Klein, Gijs Teklenburg, Ger J. A. Arkesteijn, Gisella Puga Yung, Salvo Albani, Wietse Kuis, Nico Wulffraat, Berent J. Prakken   +9 more
openalex   +1 more source

In Situ Synthesis of Covalent Organic Frameworks Inside Cells for Triggering Ferroptosis and Immunotherapy

Advanced Materials, EarlyView.
We have developed an intracellular crystalline polymerization strategy involving acid‐catalyzed imine condensation to synthesize COFs in lysosomes. The generation of COFs in lysosomes damages their integrity, activates iron species, and induces immunogenic ferroptosis, thereby enhancing antitumor immunotherapy.
Qun Guan, Le‐Le Zhou, Zhiqing Yang, Yan‐An Li, Leyong Wang, Ruibing Wang   +5 more
wiley   +1 more source

Criptococosis meníngea en un paciente con linfopenia T-CD4+ idiopática

, 2021
J. Luna, Laura Carolina Zelada Ríos, José Humberto Bejarano Ferreyra   +2 more
openalex   +2 more sources

Financing structural interventions: going beyond HIV-only value for money assessments.

, 2014
OBJECTIVE: Structural interventions can reduce HIV vulnerability. However, HIV-specific budgeting, based on HIV-specific outcomes alone, could lead to the undervaluation of investments in such interventions and suboptimal resource allocation.
Luna, Jorge, Lutz, Brian, Remme, Michelle, Vassall, Anna, Watts, Charlotte   +4 more
core   +1 more source

Cold Atmospheric Plasma‐Activated Decellularized Extracellular Matrix Gel as a Tumor‐Infiltrating Immunoactivation Platform for Post‐Surgical Cancer Immunotherapy

Advanced Materials, EarlyView.
An injectable cold atmospheric plasma‐activated decellularized tumor extracellular matrix hydrogel is introduced as a post‐surgical immunoactivation platform. The engineered gel attracts residual tumor cells and induces immunogenic cell death, reshaping the tumor microenvironment and eliciting systemic antitumor immunity. In combination with checkpoint
Tianxu Fang, Mo Chen, Yueyang Deng, Tianqin Ning, Tianwen Luo, Guojun Chen   +5 more
wiley   +1 more source

Factors associated with drug resistance mutations among antiretroviral therapy-experienced adolescents living with HIV in South Rift Valley, Kenya

Journal of Public Health in Africa
Background: Antiretroviral therapy (ART) has significantly improved survival among people living with human immunodeficiency virus (PLHIV), yet drug resistance mutations (DRMs) continue to threaten treatment outcomes globally.
Argwings O. Miruka, Louisa N. Ndunyu, Patrick O. Onyango   +2 more
doaj   +1 more source

Review for "Porphyromonas gingivalis indirectly elicits intestinal inflammation by altering the gut microbiota and disrupting epithelial barrier function through IL9‐producing CD4 + T cells"

, 2021

openalex   +1 more source

High‐Throughput In Vivo Subcellular Analysis of Gold Nanoparticles for Tumor Mitochondrial Targeting

Advanced Materials, EarlyView.
A DNA barcoding system enables high‐throughput in vivo screening of mitochondrial‐targeting gold nanoparticles. Thirty nanoparticle types with varied shapes, sizes, and ligands are individually barcoded and pooled. The pooled library is administered to tumor‐bearing mice, and barcodes retrieved from tumor mitochondria are amplified and sequenced to ...
Xingyue Huang, Xuehao Tian, Kuei Chen, Yang Wu, ChenCheng Xue, Yingjie Quek, Jessalyn Low, Arun Kumar, Andy Tay   +8 more
wiley   +1 more source