Results 281 to 290 of about 1,048,882 (334)

CD4⁺ T cells facilitate the RT-induced abscopal effect by promoting antigen cross-presentation to CD8⁺ T cells at unirradiated tumor sites. [PDF]

J Immunother Cancer
Rao X, Onyshchenko K, Wang M, Luo R, Zhang X, Wang L, Kuhn S, Yang Y, Gaedicke S, Grosu AL, Firat E, Niedermann G.   +11 more
europepmc   +1 more source

Context‐Dependent Role of GDF15: GDF15+ Tumor‐Associated Macrophages Suppress OSCC Progression by Enhancing Phagocytosis

Advanced Science, EarlyView.
This study identifies GDF15+ TAMs as a cell subset mediating tumor regression after immunotherapy. Macrophage‐intrinsic GDF15 enhances phagocytosis and antigen cross‐presentation to CD8+ T cells through the NF‐κB signaling pathway, thereby inhibiting tumor progression.
Xinyu Zhou, Zhihang Zhou, Houyu Ju, Chaoyang Guo, Fangxing Zhu, Yiyi Zhang, Xu Chen, Tongchao Zhao, Laiping Zhong, Jingzhou Hu   +9 more
wiley   +1 more source

Bipolar CD4-targeted dual-DARPin-55/57 lipid nanoparticle enables efficient CRISPR/Cas-mediated HIV-1 DNA excision and reactivation blockade in latent CD4 T cell lines. [PDF]

Mater Today Bio
Mandal S, Baloch AR, Yuan X, Chen J, Saribas AS, Zhu Y, Zhang D, Jaijyan D, Xu J, Hossain R, Sisto I, Wang H, Yang X, Li Q, Hu W.   +14 more
europepmc   +1 more source

Substituent‐Based Modulation of Self‐Assembly and Immunogenicity of Amphipathic Peptides

Advanced Science, EarlyView.
This study systematically investigates how positional and subtle changes, such as substituents on the phenyl ring attached to short amphipathic peptides, influence their self‐assembly, fibril morphology, and immunogenic responses. ABSTRACT Self‐assembled peptide‐based biomaterials provide versatile platforms for biomedical uses, featuring customizable ...
Anirban Das, Ushasi Pramanik, Elise M. Brown, Chih‐Yun Liu, Huan Gong, Jonathan Fascetti, Mark Gibson, Samuel Stealey, Silviya P. Zustiak, Cory Berkland, Piyoosh Sharma, Meredith E. Jackrel, Mark A. White, Jai S. Rudra   +13 more
wiley   +1 more source

Cytoplasmic NAD/H synthesis via NRK1 regulates inflammatory capacity and promotes survival of CD4⁺ T cells. [PDF]

Nat Commun
Stavrou V, Ali M, Gudgeon N, Bishop EL, Fulton-Ward T, Turley B, Heising S, Mohamed SH, Hain S, George L, Deng M, McCowan J, Sheriff L, Davies SP, Marzullo B, Tennant DA, Doig CL, Bending DA, Roberts EW, Lavery GG, Drummond RA, Dimeloe S.   +21 more
europepmc   +1 more source

Bifidobacterium Breve Yang08 Alleviates Atopic Dermatitis By Enriching Akkermansia Muciniphila and Inhibiting Neutrophil Extracellular Traps Formation In Mice

Advanced Science, EarlyView.
A novel Bifidobacterium breve strain, Yang08, is isolated to counter its depletion in atopic dermatitis. In mice, live Yang08 requires an intact gut microbiota to exert protection, specifically enriching Akkermansia muciniphila and potently inhibiting pathogenic neutrophil activation and NETosis in the skin.
Yanqiang Shi, Shuang He, Chengyi Li, Hung Chan, Zhenfeng Liu, Bin Yang, Qing Li   +6 more
wiley   +1 more source

Simvastatin Alleviates ConA-Induced Autoimmune Hepatitis by Inhibiting CD4⁺ T Cell Activation via Calcium-NFATC3 Pathway. [PDF]

Inflammation
Wang X, Long T, Zhou L, Xu N, Fang P, Li B, Xu H, Sun G, Zhang D, Jin H.   +9 more
europepmc   +1 more source

Combination Immunotherapy as a Promising Strategy to Overcome Immunotherapy Resistance: From Emergence to Next‐Generation Approaches

Advanced Science, EarlyView.
This review examines emerging combination immunotherapy strategies tailored to distinct tumor microenvironments and highlights next‐generation biomarkers that guide response prediction and treatment personalization. It integrates lessons from unsuccessful trials, addresses toxicity challenges, and outlines approaches for early biomarker discovery and ...
Asmita Pandey, Sudhir Kumar Rai, Li Ma, Lauren Higa, Vedbar Khadka, Hua Yang, Youping Deng   +6 more
wiley   +1 more source

TNF-⍺-mediated myeloid-instructed CD14⁺CD4⁺ T cells are associated with poor survival in lung adenocarcinoma. [PDF]

Cell Rep Med
Marceaux C, Tarasova I, Batey D, Yokote K, Gayevskiy V, Jain R, Leiwe M, Choux L, Riley L, Ribera NT, Yang E, Hywood J, Christie M, Antippa P, Speed TP, Rogers KL, Phipson B, Asselin-Labat ML.   +17 more
europepmc   +1 more source