Results 301 to 310 of about 1,048,882 (334)
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Current Opinion in Immunology, 1991
The three-dimensional structure of the binding domain of the CD4 molecule has been determined and extensive mutational analyses of the respective binding sites on gp120 and CD4 have been completed. The consequences of gp120-CD4 binding with respect to secondary changes in the virion, or the cell, that may be required for infection or that may interfere
J S, McDougal +2 more
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The three-dimensional structure of the binding domain of the CD4 molecule has been determined and extensive mutational analyses of the respective binding sites on gp120 and CD4 have been completed. The consequences of gp120-CD4 binding with respect to secondary changes in the virion, or the cell, that may be required for infection or that may interfere
J S, McDougal +2 more
openaire +2 more sources
Idiopathic CD4 lymphocytopenia
Current Opinion in Rheumatology, 2006A severe decrease of CD4 T cells predisposes humans to opportunistic infections. In adults, HIV is certainly the most common cause of CD4 lymphocytopenia, but other causes, such as infections, autoimmune diseases, immunosuppressive therapy, lymphoma and idiopathic forms need to be considered.
Walker, Ulrich A., Warnatz, Klaus
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Idiopathic CD4 lymphocytopenia
Allergy and Asthma Proceedings, 2016Idiopathic CD4 lymphocytopenia (ICL) is a rare disorder of unknown etiology. Diagnostic criteria include a persistent CD4 T-cell lymphopenia with no underlying primary or secondary immune deficiencies and a CD4 T-cell count of 300 cells/mL or 20% total lymphocyte on multiple occasions.To increase awareness of ICL and to provide a review of the clinical
Joel P, Brooks, Gisoo, Ghaffari
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The Journal of Immunology, 1994
Abstract Anti-CD4 has been extensively studied in murine models of autoimmunity and transplantation. The timing of anti-CD4 administration in these systems is critical because anti-CD4 effectively blocks primary T-dependent responses but does not diminish ongoing or memory responses in immunized animals.
J H, Chace, J S, Cowdery, E H, Field
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Abstract Anti-CD4 has been extensively studied in murine models of autoimmunity and transplantation. The timing of anti-CD4 administration in these systems is critical because anti-CD4 effectively blocks primary T-dependent responses but does not diminish ongoing or memory responses in immunized animals.
J H, Chace, J S, Cowdery, E H, Field
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CD4-dependent and CD4-independent HIV-2
AIDS, 2003HIV-2 is less pathogenic than HIV-1. In contrast to HIV-1, many isolates of HIV-2, including primary isolates, can infect cells independently of CD4.To compare the sensitivity of CD4-dependent and CD4-independent isolates of HIV-2 to antibody-mediated neutralization.The neutralization sensitivity of CD4-dependent and CD4-independent molecular clones of
Elaine R, Thomas +4 more
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Nature Immunology, 2023
Specialized subpopulations of CD4+ T cells survey major histocompatibility complex class II-peptide complexes to control phagosomal infections, help B cells, regulate tissue homeostasis and repair or perform immune regulation. Memory CD4+ T cells are positioned throughout the body and not only protect the tissues from reinfection and cancer, but also ...
Marco Künzli, David Masopust
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Specialized subpopulations of CD4+ T cells survey major histocompatibility complex class II-peptide complexes to control phagosomal infections, help B cells, regulate tissue homeostasis and repair or perform immune regulation. Memory CD4+ T cells are positioned throughout the body and not only protect the tissues from reinfection and cancer, but also ...
Marco Künzli, David Masopust
openaire +2 more sources